2-Hydroxy-6-(trifloromethyl)pyridine

2-Hydroxy-6- (trifluoromethyl) pyridine, this is an organic compound. Its properties are unique and have attracted much attention in the field of chemistry.
Looking at its physical properties, it is either a solid or a liquid under normal conditions, and its color is colorless to slightly yellow. Melting point, boiling point and other properties are determined by the interaction between molecules. The introduction of trifluoromethyl in the molecule gives this substance special physical properties. Trifluoromethyl has strong electronegativity, causing molecular polarity changes, which affects melting point, boiling point and solubility.
When it comes to chemical properties, hydroxyl groups are active functional groups and can participate in many reactions. First, esterification can occur. When it meets with acid, under appropriate catalytic conditions, the hydrogen in the hydroxyl group condenses with the hydroxyl group of the acid, and loses water to form an ester. This reaction is commonly used in organic synthesis and can produce a variety of ester compounds, which is of great significance in the fields of fragrance and drug synthesis. Second, the hydroxyl group can be substituted. In the case of nucleophiles, the hydroxyl group may be replaced by other groups, and a variety of compounds are derived to expand its application range.
Furthermore, the pyridine ring also has unique reactivity. The electron cloud on the ring is unevenly distributed, and electrophilic substitution reactions can occur at specific positions. Because trifluoromethyl has electron-absorbing properties, it will affect the electron cloud density distribution of the pyridine ring, and selectively change the electrophilic substitution reaction area. For example, electrophilic reagents may prefer to attack locations with relatively high electron cloud density on the pyridine ring.
In addition, 2-hydroxy-6- (trifluoromethyl) pyridine can act as a ligand in some metal catalytic reactions. Its structure can complex with metal ions, change the electronic environment of metal ions, and then affect the catalytic reaction activity and selectivity. This has potential application value in the field of organic synthesis catalysis, which helps to develop efficient synthesis methods.

2-Hydroxy-6- (trifluoromethyl) pyridine is used in various fields such as chemical industry and medicine.
In the chemical industry, it is often a key intermediate in organic synthesis. Due to its unique structure, containing hydroxyl groups and trifluoromethyl groups, various organic compounds can be derived through many chemical reactions, such as substitution and condensation. Based on it, it can synthesize materials with special properties, such as polymers with good heat resistance and chemical corrosion resistance, which is very useful in fields such as aerospace and electronic devices that require strict material properties.
In the field of medicine, its value is also extraordinary. It can be modified and modified to develop a variety of special drugs. Due to its structural characteristics, it may enhance the binding force of drugs to specific targets and improve their efficacy. Some drugs developed on this basis have shown good efficacy in the treatment of specific diseases. For example, in the development of anti-tumor and anti-infective drugs, they are often used as starting materials. After the design of exquisite chemical synthesis routes, they are converted into biologically active drug molecules, which brings hope for overcoming difficult diseases.
In the field of pesticides, it also has a place. It can produce highly efficient, low-toxic and highly selective pesticides. Using its structural characteristics, pesticides can precisely act on pests and reduce the impact on beneficial organisms and the environment, which is of great significance to the development of green and sustainable agriculture. Due to its unique chemical structure, it is endowed with many potential reactive activities and properties, making it an indispensable chemical substance in many important fields and making great contributions to promoting technological progress and development in various fields.

The synthesis of 2-hydroxy-6- (trifluoromethyl) pyridine is an important research in the field of chemistry. There are many methods, which are described in detail below.
First, the compound containing the pyridine structure is used as the starting material. A suitable pyridine derivative can be found, which has a substitutable group at the 6 position, and the 2-position hydroxyl group can be introduced by subsequent reactions. For example, 6-halogenated pyridine derivatives are selected, which have high halogen atom activity and are prone to substitution reactions with reagents containing trifluoromethyl groups. 6-Halo-pyridine is reacted with a trifluoromethylation reagent, such as CF-CuLi, in a suitable solvent, such as anhydrous tetrahydrofuran, at low temperature and protected by an inert gas. This condition ensures the selectivity of the reaction and the stability of the reagent, and the halogen atom is then replaced by trifluoromethyl to obtain a 6- (trifluoromethyl) pyridine derivative. Subsequent hydroxylation of 2 positions. Metal-organic reagents, such as butyllithium, can be used to treat 6- (trifluoromethyl) pyridine derivatives to lithium at the 2-position, and then react with suitable electrophilic reagents, such as borate esters, to obtain 2-hydroxy-6- (trifluoromethyl) pyridine by hydrolysis.
Second, start from the construction of pyridine rings. Using compounds containing carbonyl and amino groups as raw materials, pyridine rings are constructed by condensation cyclization. For example, 2-amino-3-trifluoromethylbenzoic acid and ethyl acetoacetate are used as starting materials. First, in the presence of acidic catalysts, such as p-toluenesulfonic acid, the two undergo a condensation reaction to form a pyridine ring skeleton. In the reaction, the amino group and the carbonyl group are condensed, and the pyridine structure is constructed by intramolecular rearrangement. Subsequently, the pyridine ring is hydroxylated and modified. The 2-position appropriate group can be oxidized to a hydroxyl group by an oxidation reaction with a suitable oxidant, such as hydrogen peroxide and a suitable catalyst system, so as to obtain the target product 2-hydroxy-6- (trifluoromethyl) pyridine.
The above synthesis methods have their own advantages and disadvantages. The practical application needs to be based on the availability of raw materials, the difficulty of reaction conditions and the yield.

I think what you are asking is about the price range of 2-hydroxy-6- (trifluoromethyl) pyridine in the market. However, the price of this chemical often changes for a variety of reasons, which is difficult to determine.
First, the influence of supply and demand is quite large. If there are many people seeking this product, but there are few producers, the price will increase; conversely, if the supply exceeds the demand, the price may drop. Second, the difficulty of preparation also affects its price. If the synthesis method is complicated, the materials used are expensive, the cost is high, and the price is not cheap; if the preparation is simple, the cost is controllable, and the price is close to the people. Third, the difference between merchants also leads to price differences. Different companies have different prices due to business strategies and cost accounting.
According to past market speculation, the price may vary depending on the purity. For high purity, the price per gram may be more than tens of yuan to hundreds of yuan; if the purity is slightly lower, the price may be slightly lower, ranging from a few yuan to tens of yuan per gram. However, this is only a rough estimate. The current situation requires detailed consultation with chemical raw material suppliers or detailed inspection on relevant chemical product trading platforms to obtain the exact price.

2-Hydroxy-6- (trifluoromethyl) pyridine, this is a chemical substance. If you want to store it well, you need to choose the storage method according to its properties.
The cover is the first to isolate the air due to its chemical activity. This substance may easily react with oxygen, water vapor, etc. in the air, causing qualitative change. Therefore, it should be stored in a sealed container to reduce its contact with air and maintain its chemical purity.
Temperature is also important. Usually it is better to keep it in a cool place and avoid high temperature. High temperature or promote its chemical reaction, causing decomposition, polymerization, etc., which will damage its structure and properties. Generally speaking, it is better to store in a refrigerated environment of 2-8 ° C, but the specific temperature depends on its physicochemical properties.
Furthermore, light also has an effect. Some of these chemicals are easy to decompose when exposed to light, so it is advisable to choose a place away from light when storing, or store them in a light-shielding container such as a brown bottle to block light exposure and maintain their stability.
And store in a dry place, waterproof vapor intrusion. Water vapor or hydrolysis and other reactions, change its chemical composition. If it is accidentally damp, it may affect its quality and use.
When handling and storing, it should also be handled with care to avoid violent vibration and collision. Because it may be fragile, and violent physical action or chemical reaction, it endangers safety and quality. The storage of 2-hydroxy-6- (trifluoromethyl) pyridine requires multiple considerations, and it should be properly stored according to its physicochemical properties, temperature control, humidity, light and other conditions to ensure its quality and safety for subsequent use.