2 Hydroxy 6 Oxo 4 Trifluoromethyl 1 6 Dihydropyridine 3 Carbonitrile
pyridine pyrrole pyrazine piperidine piperazine

2-hydroxy-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridine-3-carbonitrile

    Specifications

    HS Code

    317405

    Chemical Formula C7H3F3N2O3
    Molar Mass 220.106 g/mol
    Appearance Solid (predicted)
    Boiling Point 372.9°C at 760 mmHg (predicted)
    Melting Point 216 - 218°C
    Density 1.68 g/cm³ (predicted)
    Solubility In Water Poorly soluble
    Logp 0.24 (predicted)
    Pka 2.89 (predicted)
    Refractive Index 1.524 (predicted)

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    What is the chemical structure of 2-hydroxy-6-oxo-4- (trifluoromethyl) -1, 6-dihydropyridine-3-carbonitrile?
    This is an organic compound. In ancient Chinese, its chemical structure is analyzed as follows:
    The name "2-hydroxy-6-oxo-4- (trifluoromethyl) -1,6-dihydropyridine-3-carbonitrile" shows that this compound uses pyridine as its parent nucleus. The pyridine ring is a six-membered nitrogen-containing heterocycle with unique chemical properties.
    "1,6-dihydropyridine" indicates that the 1 and 6 positions of the pyridine ring are dihydrogen structures, that is, one hydrogen atom is added to each of these two positions, which changes the unsaturation of the pyridine ring.
    "2-hydroxy" means that the second position of the pyridine ring is connected with a hydroxyl group (-OH). The hydroxyl group is hydrophilic and can participate in many chemical reactions, such as esterification, substitution, etc.
    "6-oxo" means that the sixth position of the pyridine ring is a carbonyl group (C = O). Carbonyl is a strong electron-absorbing group, which has a great influence on the electron cloud distribution and chemical activity of compounds.
    "4- (trifluoromethyl) " means that the fourth position of the pyridine ring is connected with a trifluoromethyl group (CF-OH). Trifluoromethyl has strong electron-absorbing and hydrophobic properties, which greatly affects the physical and chemical properties of compounds.
    "3-carbonitrile" means that the third position of the pyridine ring is connected with a cyanyl group (CN). The cyanyl group can be converted into other functional groups through hydrolysis, reduction and other reactions, providing the possibility for the derivatization of compounds.
    In summary, in the structure of this compound, the pyridine ring is the core, and there are hydroxyl, carbonyl, trifluoromethyl and cyanyl functional groups connected to it. The interaction of each functional group endows the compound with unique chemical properties and reactivity.
    What are the main uses of 2-hydroxy-6-oxo-4- (trifluoromethyl) -1, 6-dihydropyridine-3-carbonitrile?
    2-Hydroxy-6-oxo-4- (trifluoromethyl) -1,6-dihydropyridine-3-formonitrile is a class of organic compounds. It has a wide range of uses and is often used as a key intermediate for synthesizing drugs in the field of medicinal chemistry. Due to its unique structure, various functional groups can be introduced by organic synthesis to construct compounds with specific biological activities, such as antibacterial, anti-inflammatory, anti-tumor and other drugs.
    In the field of materials science, it has also emerged. It can participate in the construction of polymer materials through specific reactions, giving the material special properties, such as improving the stability, optical properties or electrical properties of the material. Its unique chemical structure makes the material exhibit very different characteristics from conventional materials, and has potential application value in photoelectric materials, functional polymer films, etc.
    Furthermore, in the field of pesticide chemistry, it may also have its uses. It can be used as an important raw material for the synthesis of new pesticides, providing the possibility for the creation of high-efficiency, low-toxicity and environmentally friendly pesticides. Through the modification and modification of its structure, it is expected to develop specific pesticides for specific pests or diseases, improve the efficiency of agricultural production, and reduce the adverse impact on the environment.
    In summary, 2-hydroxy-6-oxo-4- (trifluoromethyl) -1,6-dihydropyridine-3-formonitrile has important uses in many fields such as medicine, materials, and pesticides due to its unique chemical structure, providing a rich material basis and research direction for the development of related fields.
    What are the synthesis methods of 2-hydroxy-6-oxo-4- (trifluoromethyl) -1, 6-dihydropyridine-3-carbonitrile?
    2-Hydroxy-6-oxo-4- (trifluoromethyl) -1, 6-dihydropyridine-3-carbonitrile is an important organic compound, and its synthesis method is crucial. The common methods for synthesizing this compound are as follows:
    First, the compound containing nitrile and carbonyl groups is used as the starting material and is prepared through cyclization reaction. For example, the nitrile and ketone compounds with suitable substituents are selected, and the two are condensed and cyclized under appropriate catalysts and reaction conditions. This process requires careful selection of catalysts, such as certain metal salts or organic base catalysts, to promote the smooth progress of the reaction. At the same time, the reaction temperature, reaction time and the ratio of the reactants need to be precisely regulated to obtain the ideal yield and purity.
    Second, the target molecular structure is constructed by multi-step reaction. Intermediates containing part of the target structure are synthesized first, and then further modified by reaction. For example, pyridine derivatives containing specific substituents are synthesized first, and then the structure of the target compound is gradually achieved by introducing hydroxyl, carbonyl, trifluoromethyl and other functional groups. This method requires strict control of the conditions and selectivity of each step of the reaction to ensure the yield and product purity of each step of the reaction, and the reaction sequence needs to be reasonably planned to improve the overall synthesis efficiency.
    Third, the synthesis method using the concept of green chemistry. In the synthesis process, try to use environmentally friendly solvents, catalysts and reaction conditions to reduce the impact on the environment. For example, using aqueous or solvent-free reactions to avoid the use of toxic and harmful organic solvents. At the same time, try to develop new efficient and environmentally friendly catalysts to achieve a greener and more sustainable synthesis path.
    There are many methods for synthesizing 2-hydroxy-6-oxo-4- (trifluoromethyl) -1. Researchers should choose the appropriate synthesis route according to their own experimental conditions, the requirements of the target product and the consideration of green chemistry, so as to achieve the goal of efficient and high-quality synthesis.
    What are the physical properties of 2-hydroxy-6-oxo-4- (trifluoromethyl) -1, 6-dihydropyridine-3-carbonitrile?
    2-Hydroxy-6-oxo-4- (trifluoromethyl) -1,6-dihydropyridine-3-formonitrile, this is an organic compound. Looking at its physical properties, under normal temperature, it is mostly in the shape of a solid state. Due to the interaction between molecules such as hydrogen bonds and van der Waals forces, the molecules are closely arranged, so they become solid.
    When it comes to melting point, due to the existence of polar groups such as hydroxyl and cyanyl in the molecular structure of the compound, these groups enhance the intermolecular force, resulting in a relatively high melting point. However, the exact melting point value needs to be determined according to precise experiments, and it is probably within a certain temperature range.
    As for solubility, because it has polar groups, it may exhibit some solubility in polar solvents, such as water and alcohols. Between polar solvents and polar groups of compounds, hydrogen bonds or other intermolecular forces can be formed to help compounds dissolve. In non-polar solvents, such as alkanes, solubility is quite limited. Due to the weak intermolecular forces between non-polar solvents and polar compounds, it is difficult to overcome the interaction between compound molecules and make them disperse in solvents.
    When it comes to appearance, it is often white or white-like powdery substances. This is determined by its molecular structure and crystal morphology. The characteristics of light reflection and scattering on its surface show this appearance. The density of
    is also determined by the molecular structure and packing method. Since the molecule contains relatively large groups such as trifluoromethyl, and the molecules are closely arranged, its density may be slightly higher than that of common organic compounds. However, the specific density value needs to be accurately measured through experiments.
    The physical properties of this compound are determined by its unique molecular structure, and it has important guiding value in the research and application of organic synthesis, pharmaceutical chemistry and other fields.
    What are the chemical properties of 2-hydroxy-6-oxo-4- (trifluoromethyl) -1, 6-dihydropyridine-3-carbonitrile?
    2-Hydroxy-6-oxo-4- (trifluoromethyl) -1,6-dihydropyridine-3-formonitrile, this is an organic compound with unique chemical properties. Its structure contains a pyridine ring, and the ring is connected with a hydroxyl group, an oxo group, a trifluoromethyl group and a formonitrile group. The interaction of substituents gives the compound specific reactivity and physical properties.
    From an acidic point of view, the hydroxyl hydrogen atom can be dissociated under suitable conditions, showing a certain acidity. Due to the strong electronegativity of the oxygen atom, the electron cloud connected to the hydrogen atom is biased towards oxygen, causing the hydrogen atom to leave in the form of protons. This acidity enables the compound to react with bases to form corresponding salts.
    In terms of nucleophilic reactivity, the carbon atoms in the methylnitrile group are electrophilic. Due to the large electronegativity of the nitrogen atom, the electron cloud in the carbon-nitrogen triple bond is biased towards nitrogen, resulting in a decrease in the electron cloud density of the carbon atom. Nucleophiles are prone to attack this carbon atom and initiate nucleophilic addition or nucleophilic substitution reactions, which can be used to construct new carbon-carbon bonds or carbon-hetero bonds in organic synthesis.
    Carbonyl (oxo) is also a check point for reactivity. Carbonyl carbons are electrophilic and are susceptible to attack by nucleophiles, such as nucleophilic addition reactions. Such as with alcohols under acid or base catalysis, acetal or semi-acetal structures can be formed. This reaction is often used in organic synthesis to protect carbonyl groups or build complex cyclic structures.
    In addition, the presence of trifluoromethyl significantly affects the physical and chemical properties of compounds. Trifluoromethyl has strong electron absorption, which can change the distribution of molecular electron clouds and affect the reactivity of other groups. At the same time, due to the large electronegativity of fluorine atoms and small atomic radius, compounds containing trifluoromethyl often have high stability and unique physical properties. For example, it has good solubility in some organic solvents, and due to the special properties of fluorine atoms, it has an impact on the biological activity or material properties of compounds.
    The compound may also participate in cyclization reactions. Due to its structural characteristics, reactions can occur between different active checking points in the molecule, and new cyclic structures can be formed under appropriate conditions to enrich the structural diversity of compounds, which is of great significance in the fields of organic synthesis and medicinal chemistry.