2 Hydroxy 6 Methylpyridine 3 Carboxylic Acid
pyridine pyrrole pyrazine piperidine piperazine

2-Hydroxy-6-methylpyridine-3-carboxylic acid

    Specifications

    HS Code

    684686

    Chemical Formula C7H7NO3
    Molar Mass 153.136 g/mol
    Appearance Solid (usually white or off - white powder)
    Physical State At Room Temperature Solid
    Melting Point Data may vary, typically in a certain range
    Solubility In Water Limited solubility, sparingly soluble
    Solubility In Organic Solvents Soluble in some polar organic solvents like DMSO, DMF
    Acidity Pka Has acidic hydrogen related to the carboxylic acid group, specific pKa value exists
    Odor Odorless or very faint odor

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    General Information
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    Frequently Asked Questions

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    What are the main uses of 2-Hydroxy-6-methylpyridine-3-carboxylic acid?
    2-Hydroxy-6-methylpyridine-3-carboxylic acid is a class of organic compounds. It has a wide range of uses and is often used as a key intermediate in the field of medicinal chemistry. Due to its unique chemical structure, it can be derived from compounds with biological activity through many chemical reactions, such as creating new drugs to fight specific diseases, or as an important cornerstone in the drug synthesis route, helping chemists build complex drug molecular structures.
    In the field of materials science, it also has its uses. Or it can participate in the synthesis of materials, giving materials special properties, such as improving the stability, solubility or optical properties of materials. By introducing it into the structure of materials, chemists can tailor materials with specific functions to meet the needs of different fields, such as the preparation of optical materials and polymer materials.
    In addition, in organic synthetic chemistry, 2-hydroxy-6-methylpyridine-3-carboxylic acid is often an important starting material or reagent for reactions. Because of its hydroxyl, carboxyl and pyridine ring structures, it can participate in many classic organic reactions, such as esterification reactions, amidation reactions, etc., so as to realize the construction of complex organic molecules, providing assistance for the development of organic synthetic chemistry and expanding the diversity and functionality of compounds.
    What are the physical properties of 2-Hydroxy-6-methylpyridine-3-carboxylic acid?
    2-Hydroxy-6-methylpyridine-3-carboxylic acid, this is an organic compound, its physical properties are particularly important, and it is related to many fields of application.
    In terms of its appearance, it is often white to off-white crystalline powder, with fine texture and pure appearance. This form is conducive to its treatment and use in different environments.
    Melting point is one of the key physical properties and is about a specific temperature range. This melting point value plays a decisive role in its state transition during heating. When it reaches this temperature, the substance will gradually change from solid state to liquid state. This property is of great significance for precise control of reaction conditions in chemical synthesis, material preparation and other processes. The solubility of
    cannot be ignored either. In common organic solvents, such as ethanol, acetone, etc., it has a certain solubility. This property makes it possible to select a suitable solvent according to its solubility when performing solution reactions, separation and purification, or preparing specific dosage forms, to promote the smooth progress of the reaction or to achieve effective separation. In water, its solubility is relatively limited, but it can also be dissolved to a certain extent under certain conditions. This point needs to be taken into account in applications involving aqueous systems.
    Density has its specific value. This density determines its distribution in the mixed system and has a profound impact on operations such as liquid-liquid extraction and phase separation. In the preparation of composites or heterogeneous systems, density properties help to predict and control the interaction and distribution patterns between components.
    In addition, its stability also belongs to the category of physical properties. Under normal temperature and pressure, dry environment, the substance is relatively stable and not prone to significant chemical changes. In case of high temperature, high humidity or specific chemical substances, the stability may be affected. This stability information is extremely critical during storage and transportation, ensuring that the substance maintains its inherent properties during circulation and does not deteriorate and fail.
    All these physical properties are interrelated to build the characteristic framework of 2-hydroxy-6-methylpyridine-3-carboxylic acid, providing a solid foundation for its application in many fields such as medicine, pesticides, materials science, etc.
    What are the synthetic methods of 2-Hydroxy-6-methylpyridine-3-carboxylic acid?
    There are several common methods for synthesizing 2-hydroxy-6-methylpyridine-3-carboxylic acids.
    One can be started by the corresponding pyridine derivative. First, take the appropriate methyl pyridine, and introduce the carboxyl group at the specific position of the pyridine ring through a specific oxidation reaction. For example, using 6-methylpyridine as a raw material, with the help of a suitable oxidant, under specific reaction conditions, such as controlling the reaction temperature, reaction time, and the type and amount of catalyst, etc., the methyl is oxidized to a carboxyl group. Then, another position of the pyridine ring is hydroxylated. In this hydroxylation process, a specific hydroxylation reagent can be selected. In the presence of a base, the hydroxyl group is introduced into the target position through a reaction mechanism such as nucleophilic substitution, so as to obtain 2-hydroxy-6-methylpyridine-3-carboxylic acid.
    Second, the compound containing the pyridine ring can also be reacted in multiple steps to construct the target product. For example, select a suitable pyridine precursor, first halogenate the methyl group of the pyridine ring to obtain halogenated methyl pyridine. Then use the activity of the halogenated methyl group to react with the nucleophilic reagent to introduce the substituent of the carboxyl group to construct the pyridine derivative containing the carboxyl group. After that, through the selective hydroxylation reaction, the hydroxyl group is introduced at the appropriate position of the pyrid This process requires fine regulation of the reaction conditions to ensure the selectivity and yield of the reaction.
    Third, the strategy of organic synthesis can be adopted. Starting from relatively simple raw materials, pyridine rings are constructed through multi-step cyclization reaction, and the required hydroxyl groups, methyl groups and carboxyl groups are introduced at the same time. For example, using small molecule compounds containing nitrogen and oxygen as starting materials, through a series of reactions such as condensation and cyclization, the pyridine ring structure is gradually constructed, and methyl groups, hydroxyl groups and carboxyl groups are introduced in appropriate steps. Although this method is more complicated, it can precisely control the position and structure of each substituent, and has many advantages in the synthesis of 2-hydroxy-6-methylpyridine-3-carboxylic acids with specific structures.
    The above synthesis methods have their own advantages and disadvantages. In practical applications, it is necessary to comprehensively consider the availability of raw materials, the difficulty of reaction, and the purity requirements of the target product to choose the appropriate method.
    Where is 2-Hydroxy-6-methylpyridine-3-carboxylic acid used?
    2-Hydroxy-6-methylpyridine-3-carboxylic acid, this compound has applications in medicine, pesticides, materials and other fields.
    In the field of medicine, it has potential biological activity, or can be used as a lead compound to develop new drugs. Because its structure contains pyridine ring and carboxyl, hydroxyl and other active groups, it can interact with specific targets in vivo. For example, it can be used to bind with biological macromolecules such as proteins and enzymes to regulate physiological processes in vivo, or to develop anti-tumor, antibacterial, anti-inflammatory and other drugs.
    In the field of pesticides, this compound can be used as a raw material to synthesize pesticides with high efficiency and low toxicity. Pyridine compounds often have good insecticidal, bactericidal and herbicidal activities. 2-Hydroxy-6-methylpyridine-3-carboxylic acids can be structurally modified and modified, or pesticide products that have specific effects on specific pests and bacteria can be obtained, and are environmentally friendly, with low residues, in line with the current trend of green pesticides.
    In the field of materials, it also has unique uses. With its active groups, it can participate in material synthesis and modification. For example, it can be used as a monomer to participate in polymer polymerization reactions, giving polymers specific functions, such as improving polymer solubility, thermal stability, mechanical properties, etc. Or it can be used to prepare functional coating materials to improve the adhesion and protective properties of the coating to the base material.
    In summary, 2-hydroxy-6-methylpyridine-3-carboxylic acids have shown important application value in many fields, and their potential applications may be further expanded with the deepening of research.
    What is the market outlook for 2-Hydroxy-6-methylpyridine-3-carboxylic acid?
    2-Hydroxy-6-methylpyridine-3-carboxylic acid, this is an organic compound. Looking at its market prospects, many factors cannot be ignored.
    In the field of medicine, its prospects are quite promising. Geinpyridine compounds often have unique biological activities and play an important role in drug development. 2-Hydroxy-6-methylpyridine-3-carboxylic acids may serve as key intermediates for the synthesis of drugs with specific pharmacological activities. For example, in the process of developing innovative drugs targeting specific disease targets, this material can be used as a starting material, and through delicate chemical modifications and reactions, new drugs with excellent efficacy and mild side effects may be created. With the increasing aging of the global population and the increasing emphasis on health, the demand for novel drugs in the pharmaceutical market continues to rise, which undoubtedly brings a broad market space for 2-hydroxy-6-methylpyridine-3-carboxylic acids.
    In the field of pesticides, it also has potential. Pyridine structures are common in the creation of pesticides, and have many advantages such as high efficiency, low toxicity and environmental friendliness. 2-hydroxy-6-methylpyridine-3-carboxylic acids may be converted into pesticide ingredients with insecticidal, bactericidal or herbicidal activities. With the increasing attention to food safety and environmental protection, the development of green and efficient pesticides has become the general trend. New pesticides developed on the basis of this compound are in line with this development trend and are expected to win a place in the pesticide market.
    However, its market expansion also faces challenges. The complexity and cost of the synthesis process are the key. If the synthesis route is long and harsh, it will lead to high production costs, thereby weakening the competitiveness of the product market. Furthermore, regulations and policies are increasingly strict in the supervision of the pharmaceutical and pesticide industries. The production of 2-hydroxy-6-methylpyridine-3-carboxylic acids for related products needs to meet strict regulatory standards, which also adds compliance costs and technical thresholds for manufacturers. But overall, if we can break through the technical bottleneck, optimize the synthesis process, reduce costs, and comply with regulatory requirements, the market prospect of 2-hydroxy-6-methylpyridine-3-carboxylic acid will be quite bright, and it may be useful in fields such as medicine and pesticides.