2-Hydroxy-6-methoxy-3-nitropyridine

2-Hydroxy-6-methoxy-3-nitropyridine is widely used in the chemical and pharmaceutical fields.
In the chemical industry, it is often a key intermediate in organic synthesis. Because of its specific chemical structure and activity, it can be converted into other compounds with unique functions through various chemical reactions, such as nucleophilic substitution, reduction, etc. In this way, a variety of fine chemicals can be prepared, such as pigments, fragrances and functional materials, which are important cornerstones of chemical synthesis and expand the variety and properties of chemical products.
In the field of medicine, its significance is also extraordinary. The structural characteristics of this compound endow it with potential biological activity, or it can become a lead compound for drug development. By modifying and optimizing its structure, the affinity and selectivity for specific targets can be improved, and new drugs with better curative effect and less side effects can be developed. Or it can show unique pharmacological effects for certain diseases, such as inflammation, tumors, etc., and contribute to human health.
In summary, 2-hydroxy-6-methoxy-3-nitropyridine occupies an indispensable position in the modern chemical industry and pharmaceutical research process due to its unique use in the chemical and pharmaceutical fields.

2-Hydroxy-6-methoxy-3-nitropyridine, this is also an organic compound. Its physical properties are unique, let me tell you in detail.
Looking at its appearance, it is often in a solid state, but the exact color state may vary depending on the purity and preparation method. Generally speaking, it is a white-like to light yellow crystalline powder.
As for the melting point, this is an important physical constant. According to relevant data and the characteristics of common organic compounds, its melting point should be within a certain range, but the exact value needs to be determined by precise experiments. Because the melting point of organic compounds is affected by many factors such as molecular structure and crystal form. There are functional groups such as hydroxyl, methoxy and nitro in the molecule of this compound, and the interaction of these functional groups must affect its melting point. Hydroxyl groups can form hydrogen bonds, enhance the intermolecular force, and increase the melting point; while the strong electron-absorbing properties of nitro groups can also change the molecular charge distribution, affect the intermolecular interaction, and then affect the melting point.
In terms of solubility, its performance in organic solvents is quite critical. Generally speaking, in view of the fact that its structure contains both polar hydroxyl groups, nitro groups, and non-polar pyridine rings and methoxy groups, it may have a certain solubility in polar organic solvents such as methanol and ethanol. Because hydroxyl groups and nitro groups can form hydrogen bonds with the hydroxyl groups of methanol and ethanol to promote dissolution. However, in non-polar organic solvents such as n-hexane, the solubility may be low, because the non-polar part is relatively small, it is difficult to dissolve well with non-polar solvents. The solubility in water, or because the molecular polarity is not enough to overcome the hydrogen bonding between water molecules, the solubility may be limited.
In addition, its density is also one of the physical properties. Although the exact density data needs to be measured experimentally, it can be inferred slightly based on the structure. Because the molecule contains elements with relatively large atomic mass such as nitrogen and oxygen, and the structure is relatively compact, its density may be larger than that of water.
In conclusion, the physical properties of 2-hydroxy-6-methoxy-3-nitropyridine are of great significance in the fields of organic synthesis and drug development. Researchers can choose suitable separation, purification and reaction conditions according to their physical properties to achieve the desired research purposes.

To prepare 2-hydroxy-6-methoxy-3-nitropyridine, there are three methods.
First, start with 2-chloro-6-methoxy pyridine, react with sodium nitrite and acid to form diazonium salt, followed by treatment with sodium nitrate and sulfuric acid, introduce nitro group, and then hydrolyze with alkali to obtain the target product. The reaction conditions are harsher, temperature control is required, by-product prevention is prevented, and the yield is still acceptable.
Second, from 2-methoxy-6-hydroxypyridine, nitrate with a mixed acid of nitric acid and sulfuric acid. The key to this process is to control the proportion of mixed acids and the reaction temperature to prevent polynitrification. Although the steps are simple, the separation of the product may be difficult due to the by-production of polynitrification.
Third, with 2-methoxy pyridine as the group, first in a suitable solvent, nitrolyzed with reagents such as cerium ammonium nitrate to obtain 2-methoxy-3-nitropyridine, then in the alkali solution with methylating reagents such as dimethyl sulfate, methoxy is introduced, and finally hydrolyzed under acidic or basic conditions to obtain 2-hydroxy-6-methoxy-3-nitropyridine. This step is a little more complicated, but the reaction is milder, the product is easy to control, and the yield and purity are good.
All these methods have advantages and disadvantages. In actual synthesis, when the availability of raw materials, cost, equipment conditions and product requirements, etc., choose carefully.

I look at your question, but I am inquiring about the market price of 2-hydroxy-6-methoxy-3-nitropyridine. However, it is not easy to clarify its price, and the market price often changes for many reasons.
The price of this compound is primarily related to the trend of supply and demand. If there are many people who want it, but the supply is small, the price will increase; conversely, if the supply exceeds the demand, the price will be depressed. And the difficulty of its preparation also affects. If the preparation method is complicated, requires a lot of materials and man-hours, the cost will increase, and the price will follow. The price of the raw materials used is also a major factor. If the price of the raw materials is high, the price of the finished product will also increase.
Furthermore, in different places and at different times, the price is also different. In prosperous places, transactions are frequent, or the price is slightly flat due to competition; in remote places, circulation is inconvenient, and the price is higher. The changes of time, prices fluctuate, and the price fluctuates.
As for the exact price, it is difficult to find details in ancient books such as "Tiangong Kaiwu". To know the current market price of this compound today, it is necessary to consult the merchants of chemical raw materials, trade platforms, or those who specialize in the industry to obtain a more accurate number. And it is advisable to compare the quotations from different channels several times to understand the approximate range of its market price.

2-Hydroxy-6-methoxy-3-nitropyridine is a chemical substance, and many matters need to be paid attention to during storage and transportation.
First talk about storage. This substance should be placed in a cool, dry and well-ventilated place. Cover because of its nature or susceptible to temperature and humidity, if it is in a warm and humid place, it may cause deterioration. The temperature of the warehouse should be controlled within a suitable range to prevent chemical reactions caused by excessive temperature and damage to its quality. And keep away from fires and heat sources, because it may be flammable, it will be dangerous in case of open flames and hot topics. Furthermore, it should be stored separately from oxidants, acids, bases, etc., and must not be mixed. Due to its active chemical properties, contact with such substances is prone to chemical reactions, resulting in danger.
As for transportation. Be sure to ensure that the packaging is complete and sealed before transportation. Packaging materials must be able to resist vibration, collision and friction to avoid material leakage due to package damage. During transportation, the speed of the vehicle should not be too fast, nor should it be braked abruptly to prevent damage to the packaging due to bumps and collisions. Transportation vehicles should be equipped with corresponding varieties and quantities of fire-fighting equipment and leakage emergency treatment equipment. If a leak occurs during transportation, effective measures can be taken quickly according to its characteristics, such as adsorption with inert materials, to avoid polluting the environment and endangering personal safety. And transportation personnel should be professionally trained and familiar with the characteristics of this substance and emergency treatment methods to ensure the safety of transportation.