2 Hydroxy 5 Trifluoromethyl Pyridine
pyridine pyrrole pyrazine piperidine piperazine

2-HYDROXY-5-(TRIFLUOROMETHYL)PYRIDINE

    Specifications

    HS Code

    788212

    Chemical Formula C6H4F3NO
    Molecular Weight 163.097 g/mol
    Appearance Typically a solid (appearance can vary based on purity and handling)
    Melting Point Data may vary, specific experimental conditions required for accurate value
    Solubility Solubility properties would depend on the solvent; likely has some solubility in polar organic solvents
    Pka The hydroxy group on the pyridine ring may have a characteristic pKa value relevant for acid - base chemistry
    Vapor Pressure Low vapor pressure expected due to its relatively high molecular weight and polar nature
    Stability Stable under normal conditions, but reactivity can be affected by presence of reactive groups like the hydroxy and trifluoromethyl groups

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    Frequently Asked Questions

    As a leading 2-HYDROXY-5-(TRIFLUOROMETHYL)PYRIDINE supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the main uses of 2-hydroxy-5- (trifluoromethyl) pyridine?
    2-% pentyl-5- (triethylmethyl) pyridine has many main uses.
    First, in the field of medicine, this compound may have unique medicinal potential. Or it can be modified by delicate chemistry to create new drugs. Because of its specific chemical structure, it may be able to precisely combine with human biological macromolecules to play a role in regulating physiological functions. For example, it can be used as a key active ingredient to develop targeted drugs for specific diseases and help the development of precision medicine, which may be of great significance for the treatment of certain complex diseases.
    Second, in the field of materials science, this substance also has potential application value. Or it can be used to prepare materials with special properties, which by virtue of their own structural characteristics endow materials with good electrical conductivity, unique optical properties or excellent stability. For example, it can be applied to the preparation of new electronic materials, providing the possibility of miniaturization and high performance of electronic devices; or it can be used to prepare special optical materials, which play a role in optoelectronic devices, optical displays and other fields.
    Third, in the field of organic synthesis chemistry, 2-% pentyl-5- (triethylmethyl) pyridine can act as a key intermediate. With the help of the exquisite skills of organic synthesis, using it as a starting material can be converted through a series of reactions to construct more complex organic compounds with specific functions. This helps to expand the boundaries of organic synthesis, create more novel compounds with novel structures, and provide a rich material basis for chemical research and industrial production.
    Fourth, in the field of agriculture, it may be developed as a new type of pesticide. Based on its special action mechanism against certain pests or pathogens, develop high-efficiency, low-toxicity and environmentally friendly pesticide products, help green prevention and control of crop diseases and pests, and ensure the sustainable development of agriculture.
    What are the physical properties of 2-hydroxy-5- (trifluoromethyl) pyridine?
    2-% heptyl-5- (trifluoromethyl) pyridine, this is a quirky synthesis, and its physical properties are very unique.
    Looking at its properties, under normal conditions, it is mostly a colorless to light yellow transparent liquid, just like a clear autumn water, flowing with a smart light. Approaching and sniffing, it often has a special smell, although not pungent, it is unique, as if telling its own unique structure.
    When it comes to the melting point, the melting point is very low, just like the thin ice that is easy to melt in winter, and it turns into a liquid at a lower temperature. The boiling point is relatively moderate, and within a specific temperature range, it will be like a smart spirit, transforming from liquid light to gaseous. This property allows it to subtly adjust its state according to temperature during many chemical reactions and separation and purification steps, as if it can dance with a baton.
    Solubility is also one of its major characteristics. In the embrace of organic solvents, it can easily dissolve, like a duck to water. Whether it is common ethanol, ether, or other organic solvents, it can blend with it to form a uniform and stable system. However, in water, it is like a shy guest, difficult to be intimate with water, and its solubility is extremely low, as if there is an invisible yarn separated from water.
    In terms of density, it is slightly lighter than water. If it is placed in one place with water, it will float leisurely on the water surface, like a light boat floating on the blue waves.
    In addition, its volatility cannot be underestimated. In an open environment, it will evaporate slowly, just like the light fog in the mountains, gradually dissipating into the air. This requires that proper measures must be taken during storage and use to prevent its escape.
    These various physical properties together outline the unique "face" of 2-% heptyl-5- (trifluoromethyl) pyridine, which has laid a solid foundation for its application in chemical, pharmaceutical and other fields.
    What are the synthesis methods of 2-hydroxy-5- (trifluoromethyl) pyridine?
    To prepare 2-cyano-5- (trifluoromethyl) pyridine, there are three methods.
    One is the halogenated pyridine nitrile method. Starting with halogenated pyridine, cyano is introduced first, followed by trifluoromethyl. If 2-chloropyridine is used as a substrate, it is co-heated with cuprous cyanide, and in a suitable solvent, such as N, N-dimethylformamide, and nucleophilic substitution, 2-cyanopyridine is obtained. Then it is used as a raw material and reacted with a trifluoromethylating agent, such as sodium trifluoromethanesulfonate, under the action of a catalyst, at a suitable temperature, the target product can be obtained. The raw materials in this way are easy to obtain, but the steps are slightly complicated, and the reaction conditions need to be carefully regulated to ensure the yield of each step.
    The second is the direct cyanidation of pyridine derivatives. Select the pyridine derivative containing trifluoromethyl to make it directly cyanide. With 5- (trifluoromethyl) pyridine as the base, in the presence of an appropriate base and catalyst, react with cyanide reagents, such as zinc cyanide, trimethylsilyl cyanide, etc. The key to this process is to select the appropriate base and catalyst. For example, the base can be used potassium carbonate, potassium tert-butyl alcohol, etc. The catalyst can be selected from complexes such as palladium and copper to precisely control the reaction check point, improve the selectivity of cyanide introduction, and
    The third method is the construction of heterocyclic rings. Pyridine rings are constructed by multi-step reaction, and cyanyl groups and trifluoromethyl groups are introduced at the same time. For example, small molecules containing cyanyl groups and trifluoromethyl groups are used as raw materials, and they are cyclized with appropriate enamines, enols, etc. to form pyridine rings. This approach is innovative and can design molecular structures from the source. However, the reaction mechanism is complex, the conditions are harsh, and the requirements for reaction equipment and operation are quite high.
    All these methods have advantages and disadvantages. The halogenated pyridinium nitrile method is common in raw materials and slightly easier to operate; the direct cyanidation of pyridine derivatives is highly challenging; the heterocyclic construction method has innovative potential and high difficulty In actual preparation, the choice should be made carefully according to the availability of raw materials, cost, yield and purity requirements.
    What are the precautions for storing and transporting 2-hydroxy-5- (trifluoromethyl) pyridine?
    When storing and transporting 2-% heptyl-5- (triethylamino) pentane, careful attention should be paid to many matters.
    Its nature may be unstable, and it may react violently in case of heat, open flame or strong oxidant, and even cause ignition and explosion. Therefore, when storing, it is advisable to choose a cool and ventilated warehouse to avoid fire and heat, and store it separately from oxidants and acids, and must not be mixed. The warehouse temperature should not exceed 30 ° C to prevent it from being dangerous due to heat.
    When transporting, extra care must also be taken. Transportation vehicles should be equipped with corresponding varieties and quantities of fire equipment and leakage emergency treatment equipment. Summer transportation should be selected in the morning and evening to avoid high temperature periods. During transportation, make sure that the container does not leak, collapse, fall, or be damaged. Road transportation follows the specified route and does not stop in residential areas and densely populated areas.
    In addition, this substance may be toxic and irritating to a certain extent, posing a potential threat to human health. When operating, operators must wear appropriate protective equipment, such as gas masks, chemical safety glasses, anti-toxic infiltration overalls, rubber gloves, etc., to prevent contact or inhalation. If you accidentally contact, you should quickly rinse with a lot of water. If you feel unwell, you must seek medical attention immediately.
    Storage and transportation of 2-% heptyl-5- (triethylamino) pentane, all links must be strictly operated in accordance with regulations, and must not be slack, so as to ensure safety.
    What is the market price range for 2-hydroxy-5- (trifluoromethyl) pyridine?
    Today there is 2-cyano-5- (trifluoromethyl) pyridine, want to know its market price. This product is in the market, and the price varies according to quality, quantity, supply and demand.
    If it is of high quality, less supply and more demand, the price will be high. Or due to the difficulty of preparation, the high cost of raw materials, and the complexity of the process, the cost will be high, and the price will also be high. Its price may be several gold per gram, or even tens of gold.
    On the contrary, if the quality is average, more supply and less demand, the price will be lower. And if you buy in large quantities, the price may be favorable. In order to promote sales, merchants often give discounts when purchasing in bulk, and the price per gram may be reduced to less than a few gold.
    However, the market situation changes, and the price is also unstable. To know the exact price, when consulting the chemical raw material supplier, or visiting the chemical trading platform, you can get a recent and accurate price range.