2-Hydroxy-5-nitro-6-methyl-pyridine

2-Hydroxy-5-nitro-6-methylpyridine, this property belongs to the category of organic chemistry. It is a nitrogen-containing heterocyclic compound with unique chemical properties.
Looking at its structure, the hydroxyl group, nitro group and methyl group are all connected to the pyridine ring. Hydroxy (-OH) is hydrophilic and can cause molecules to form hydrogen bonds with water, so it may have a certain solubility in water. And hydroxyl groups can participate in many chemical reactions, such as esterification reactions, which can react with acids to form esters; substitution reactions can also occur, and the hydrogen of hydroxyl groups can be replaced by other groups.
Nitro (-NO ³) is a strong electron-absorbing group, which will reduce the electron cloud density of the pyridine ring, increase the difficulty of electrophilic substitution reaction on the ring, but can activate the ortho and para-sites, making the nucleophilic substitution reaction more prone to occur. At the same time, nitro makes the compound have a certain degree of oxidation, and can participate in the redox reaction under specific conditions.
methyl (-CH 🥰) is an electron-supplying group. Although the electron-supplying ability is relatively weak, it will affect the electron cloud distribution of the pyridine ring, change the charge density on the ring, and have a certain impact on its chemical activity. Due to the presence of methyl groups, the lipid solubility of the compound may increase, and the solubility in organic solvents may increase.
2-Hydroxy-5-nitro-6-methylpyridine exhibits complex and unique chemical properties due to the interaction of these groups, which may have important application value in organic synthesis, medicinal chemistry and other fields.

2-Hydroxy-5-nitro-6-methylpyridine has important uses in many fields such as chemical industry and medicine.
In the chemical industry, it is often used as an intermediary in organic synthesis. Due to its structure containing special functional groups, it can be derived from a series of chemical reactions. For example, it can form new carbon-nitrogen or carbon-oxygen bonds with halogenated hydrocarbons through substitution reactions, paving the way for the synthesis of complex organic molecules; it can also participate in condensation reactions, react with aldehyde and ketone compounds to form products with specific structures and properties, and is of great significance in the preparation of fine chemicals such as dyes and fragrances.
In the field of medicine, its role should not be underestimated. Many studies have shown that such compounds have potential effects on specific biological activities. It may be used as lead compounds to develop new drugs with pharmacological activity through structural modification and optimization. It may act on specific biological targets, regulate physiological processes in organisms, and show potential value in the treatment of certain diseases, such as antibacterial and anti-inflammatory, providing new opportunities and directions for pharmaceutical research and development.
With its unique chemical structure, this compound is of key significance in the expansion of chemical synthesis and the exploration of pharmaceutical innovation, promoting the progress and development of technologies in related fields.

To prepare 2-hydroxy-5-nitro-6-methylpyridine, the following method can be used.
First, a suitable raw material, such as 6-methylpyridine, is used as the starting material. Due to the specific electron cloud distribution of the pyridine ring, functional groups can be introduced under suitable conditions. First, 6-methylpyridine is nitrified with an appropriate nitrifying agent, such as a mixed acid of concentrated nitric acid and concentrated sulfuric acid. In this mixed acid, concentrated sulfuric acid has a dehydrating effect, which can promote the formation of nitric acid into nitroyl positive ion (NO ²), which is an electrophilic agent. On the pyridine ring of 6-methylpyridine, the methyl group is the ortho-para-localization group. Because the nitrogen atom of the pyridine ring absorbs electrons, the density of the ortho-para-electron cloud is relatively high, so the nitroyl positive ion is easy to attack the ortho-position or para-position of the methyl group, and 5-nitro-6-methylpyridine can be obtained.
However, the reaction conditions need to be carefully controlled, and the temperature should not be too high to prevent excessive nitrification or the formation of by-products. After 5-nitro-6-methylpyridine is obtained, the hydroxylation reaction is carried out. The principle of hydrolysis of halogenated hydrocarbons can be used to introduce halogen atoms into the pyridine ring of 5-nitro-6-methylpyridine with halogenated reagents, such as chlorine or bromine, under appropriate catalysts, to form 5-nitro-6-methyl-2-halopyridine. After that, the halogen is treated with alkali solution, and the halogen atom is replaced by hydroxyl group through nucleophilic substitution reaction to obtain 2-hydroxy-5-nitro-6-methylpyridine.
During this period, the separation and purification of each step of the reaction are also key. After the nitration reaction, pure 5-nitro-6-methylpyridine can be obtained by extraction, distillation and other methods. After the halogenation reaction and the hydroxylation reaction, suitable separation methods, such as column chromatography, recrystallization, etc., are also required to obtain high-purity target products 2-hydroxy-5-nitro-6-methylpyridine, so as to obtain the best effect.

I look at the "2 - Hydroxy - 5 - nitro - 6 - methyl - pyridine" you are asking about. This substance has a wide range of uses, or involves many fields such as medicine and chemical industry. Its price varies depending on a number of factors such as quality, purity, market supply and demand.
In the past, if you look for low purity, the price per gram may be between a few yuan and a few tens of yuan. However, if it is high purity and reaches the scientific research level, the price per gram may rise to more than 100 yuan.
Looking at the chemical market, in the past, when there were sufficient raw materials, many manufacturers and fierce competition, its price stabilized or decreased slightly. On the contrary, if the raw materials are scarce, or the production process is complicated and the output is limited, the price will rise.
And the purchase volume is also related to the price. If you buy in bulk, the merchant may give a discount due to the large quantity, and the unit price may be reduced.
However, the market changes and prices fluctuate. To know the current precise price range, it is recommended to consult chemical product suppliers, chemical trading platforms, or professional chemical information agencies to obtain the exact number to meet the needs.

2-Hydroxy-5-nitro-6-methylpyridine is a kind of organic compound. Its storage conditions are crucial to the stability and quality of this substance.
Cover 2-hydroxy-5-nitro-6-methylpyridine, its properties may be more active and susceptible to external factors. The first to bear the brunt is the temperature. It should be stored in a cool place to avoid high temperature and heat. Under high temperature, the molecular movement intensifies, or its structure changes, triggering the risk of decomposition and deterioration. Therefore, it is better to have an environment not exceeding 25 ° C, if it can be maintained between 15-20 ° C, it is more appropriate.
Secondly, the humidity cannot be ignored. This material may have a certain degree of hygroscopicity, and if the humidity is too high, it is easy to absorb water vapor, which not only affects the purity, but also triggers a chemical reaction. Therefore, when placed in a dry place, the relative humidity should be controlled at 40% - 60%. A desiccant can be placed in the storage place to keep the environment dry.
Furthermore, light also affects it. Light or luminescent chemical reactions destroy its molecular structure. Therefore, it needs to be stored away from light. It should be stored in a brown bottle or opaque container and placed in a dark place, protected from direct light.
In addition, 2-hydroxy-5-nitro-6-methylpyridine may be toxic and corrosive, and should be stored separately from other chemicals, especially oxidizing, reducing substances and acids and bases, to prevent interaction and cause danger. And the storage area should be well ventilated. In case of leakage, harmful gases can be discharged in time to reduce hazards.
In summary, 2-hydroxy-5-nitro-6-methylpyridine should be stored in a cool, dry, dark place, reasonably separated from other chemicals, and well ventilated to ensure its quality and safety.