2-Hydroxy-5-methyl-3-nitropyridine

2-Hydroxy-5-methyl-3-nitropyridine is one of the organic compounds. It has a wide range of uses and is often used as an intermediate in drug synthesis in the field of medicinal chemistry. Due to the special chemical structure of this compound, it can be combined with other compounds through various chemical reactions. After ingenious construction, it finally becomes a drug molecule with specific pharmacological activity.
In the field of pesticide chemistry, it also plays an important role. Or it can be specifically transformed to produce pesticide ingredients with pest control effects. With its chemical properties, it can affect the physiological functions of pests, such as interfering with the nervous system of pests, inhibiting their growth and development, etc., and then achieve the purpose of protecting crops.
In addition, in the field of materials science, 2-hydroxy-5-methyl-3-nitropyridine may participate in the preparation of functional materials. By combining or reacting with other materials, the material is endowed with unique properties such as special optical and electrical properties to meet the needs of different application scenarios. In short, this compound plays an important role in many fields, and with its unique structure and chemical properties, it provides assistance for the development of various fields.

2-Hydroxy-5-methyl-3-nitropyridine is one of the organic compounds. Its physical properties are quite impressive, so let me tell you one by one.
First of all, its appearance is usually solid. As for the color, it often shows a light yellow color, just like the early blooming of autumn chrysanthemum, with a light color. The characterization of this color can be an important basis for identifying this substance.
Second, its melting point is about a certain temperature range. This temperature range is of great significance for accurately understanding the physical properties of this substance. When the temperature gradually rises to the melting point, this substance slowly melts from the solid state into a liquid state, just like ice and snow melting when warm. The determination of the melting point can not only be used to judge its purity, but also provide key data support for its application in different processes.
In addition, its solubility is also a major feature. In common organic solvents, such as ethanol and acetone, this substance can have a certain solubility. This characteristic allows it to be skillfully separated from the mixture by suitable solvents during synthesis and purification. When dissolved in ethanol, it is like a fish getting water, which can be evenly dispersed to form a uniform system. In water, its solubility is relatively limited, but it is not completely insoluble. This subtle difference needs to be carefully considered in practical applications.
In addition, the density of this substance also has its specific value. Density is related to its ups and downs in different media, and is an indispensable consideration in many aspects of chemical production and storage. Only by accurately knowing its density can we reasonably plan the dosage and storage method of materials, and ensure the safety and efficiency of production and storage.
The physical properties, appearance, melting point, solubility and density of 2-hydroxy-5-methyl-3-nitropyridine play a pivotal role in its application in organic synthesis, drug development and other fields. Only by making good use of its physical properties can it maximize its effectiveness in many fields.

The chemical stability of 2-hydroxy-5-methyl-3-nitropyridine is related to many aspects. This compound has different functional groups such as hydroxyl, methyl and nitro, and each functional group has a unique impact on its chemical stability.
Hydroxy is an active group and can participate in many chemical reactions. In acidic or alkaline environments, hydroxyl groups may undergo protonation or deprotonation reactions, which in turn affect the charge distribution and reactivity of molecules. And hydroxyl groups can act as hydrogen bond donors or receptors, forming hydrogen bonds with surrounding molecules, which may change their physical and chemical properties. Although the
methyl group is relatively stable, it also has an effect on the electron cloud distribution of molecules. The electron cloud density of the adjacent or para-position can be increased by the electron supply effect of the methyl group, which affects the reaction activity of the molecule to the electrophilic reagents. The
nitro group is a strong electron-absorbing group, which can significantly affect the electron cloud density and charge distribution of the pyridine ring. The presence of nitro groups decreases the electron cloud density of the pyridine ring, especially the electron cloud density of the adjacent and para-position, which decreases the activity of the molecule for the electrophilic substitution reaction, but may increase the activity of the nucleophilic substitution reaction.
Under normal conditions, 2-hydroxy-5-methyl-3-nitropyridine may have certain stability. When encountering extreme conditions such as high temperature, strong acid, strong base or strong oxidant, its chemical stability may be challenged. High temperature or cause the vibration of chemical bonds in molecules to intensify, and when it reaches a certain extent, the chemical bonds may be broken. Strong acids and strong bases can react with hydroxyl groups, pyridine rings, etc., to change the molecular structure. Strong oxidants may cause oxidation reactions of groups such as nitro and methyl groups.
Overall, the chemical stability of 2-hydroxy-5-methyl-3-nitropyridine is not absolute and depends on the specific environment and conditions. Under suitable mild conditions, it may be able to maintain a relatively stable state; however, in severe special environments, its chemical properties may change significantly.

The synthesis of 2-hydroxy-5-methyl-3-nitropyridine, through the ages, has various techniques.
First, it can be started from a suitable pyridine derivative. A certain type of pyridine containing a specific substituent is used as the raw material, and the methyl group is introduced at a specific position first. This process requires careful selection of reaction conditions and reagents, such as the use of suitable halogenated methane, catalyzed by a base, through nucleophilic substitution, the methyl group is bonded to the designated carbon position of the pyridine ring.
Then, nitro is introduced. The mixed acid of concentrated nitric acid and concentrated sulfuric acid is often used as the nitrification reagent. According to the electron cloud distribution characteristics of the pyridine ring, the reaction temperature and time are precisely controlled, so that the nitro group is precisely introduced into the target position, and the pyridine intermediate containing methyl group and nitro group is obtained.
Finally, the introduction of hydroxyl groups can be achieved by specific nucleophilic substitution or hydrolysis reactions. If a substituent on the pyridine ring can be hydrolyzed into hydroxyl groups, under suitable acid-base conditions, the reaction process can be properly regulated, and then 2-hydroxy-5-methyl-3-nitropyridine is obtained.
Second, other heterocyclic compounds are also used as starting materials to construct pyridine rings through multi-step cyclization reactions. First, the compounds with potential pyridine ring structure fragments are designed and synthesized, and the pyridine ring skeleton is formed by cyclization and condensation reaction. During the cyclization process, the introduction sequence of substituents is cleverly planned, so that methyl, nitro and hydroxyl groups are connected to the pyridine ring in the appropriate steps and accurate positions. After many optimization of the reaction conditions, the final product is obtained.
The process of synthesis requires detailed investigation of the details of each step of the reaction, from the selection of raw materials, the ratio of reagents, to the control of the reaction temperature and time, all of which are related to success or failure. Only by carefully studying all the elements can an efficient and accurate synthesis method be obtained to obtain 2-hydroxy-5-methyl-3-nitropyridine.

I have not obtained the exact price of 2-hydroxy-5-methyl-3-nitropyridine on the market, but if I want to estimate its price, I need to review multiple ends. First, the preparation of this compound is difficult and easy. If its synthesis method is complicated, the materials used are rare and expensive, and the steps are cumbersome, and special equipment and high-tech craftsmen are required, the price will be high. Second, the situation of supply and demand is also serious. If it is needed in the fields of medicine and chemical industry, the price will be higher. Third, purity is related to the price. Those with high purity are used for fine experiments or specialties, and the price is higher than that of ordinary purity.
Looking at the price of this compound in the past, in the market of fine chemical raw materials, if the purity is ordinary, the price per gram may be between tens and hundreds of yuan. If it is high purity, used in pharmaceutical research and development, etc., the price per gram may exceed 100 yuan, or even hundreds of yuan is unknown. However, this is only an idea. The market situation is ever-changing, and the fluctuation of raw material prices, the innovation of processes, and the impact of policies can all cause its price to fluctuate. To know the exact price, you should consult chemical raw material suppliers, chemical trading platforms, or related companies to get a near-real price.