2-Hydroxy-5-iodopyridine

2-Hydroxy-5-iodopyridine is one of the organic compounds. It has a wide range of uses and has its own impact in various fields.
is the first to bear the brunt. In the field of medicinal chemistry, it can be used as a key intermediate. Pharmaceutical developers often use this as a basis to carefully construct drug molecules with more complex structures and more specific functions through various chemical reactions. Due to its unique chemical structure, it can endow the synthesized drugs with specific biological activities, such as antibacterial, anti-inflammatory, and anti-tumor effects. For example, cleverly designed reaction routes can be fused with other nitrogen-containing and oxygen-containing heterocyclic compounds to prepare new drugs with high affinity and selectivity for specific disease targets, which contribute greatly to human health and well-being.
Furthermore, in the field of materials science, 2-hydroxy-5-iodopyridine also plays an indispensable role. Because it has both hydroxyl and iodine atoms, it can participate in many polymerization reactions to prepare functional materials with excellent performance. For example, polymerization with certain conjugated monomers can generate polymeric materials with special optical and electrical properties. Such materials may be applied to organic Light Emitting Diodes (OLEDs), solar cells and other optoelectronic devices to improve the performance of the device, such as improving the luminous efficiency, enhancing the photoelectric conversion efficiency, etc., and promoting the progress of materials science and optoelectronic technology.
In addition, in the field of organic synthetic chemistry, as an important synthetic building block, it provides an effective way for the construction of many complex organic molecules. Chemists can flexibly use various organic reactions, such as nucleophilic substitution reactions, coupling reactions, etc. according to their structural characteristics, to connect them with other organic fragments, thereby expanding the structural diversity of organic molecules, laying the foundation for the synthesis of organic compounds with novel structures and unique properties, and also playing a positive role in the development of organic synthesis methodologies.

The synthesis method of 2-hydroxy-5-iodopyridine has been investigated by many parties throughout the ages, and the current Chen number method is below.
First, 2-hydroxy pyridine is used as the starting material and can be obtained by halogenation reaction. First, 2-hydroxy pyridine is placed in an appropriate solvent, such as dichloromethane, and then an appropriate amount of halogenating reagent, such as N-iodosuccinimide (NIS), is added. The reaction system needs to be carried out at a low temperature and stirred under the condition, usually the temperature is controlled at 0 ° C to 5 ° C. In this process, the iodine atom of the halogenated reagent selectively replaces the hydrogen atom at the 5-position on the pyridine ring, and then generates 2-hydroxy-5-iodopyridine. This method is relatively simple to operate, and the raw materials are relatively easy to obtain. However, the control of the reaction conditions is very critical. If the temperature is too high, it is easy to produce side reactions, resulting in a decrease in the purity of the product.
Second, 2-amino-5-iodopyridine is prepared by diazotization and hydrolysis. First, 2-amino-5-iodopyridine reacts with sodium nitrite in an acidic medium to form a diazonium salt. The commonly used acidic medium is hydrochloric acid, and the reaction temperature should be controlled at 0 ° C to 5 ° C. After the diazonium salt is formed, it is hydrolyzed under appropriate conditions, and the diazonium group is replaced by the hydroxyl group to obtain 2-hydroxy-5-iodopyridine. This pathway has a little more steps, but the selectivity is quite good, which can effectively avoid side reactions at other positions on the pyridine ring, which is conducive to obtaining high-purity products.
Third, the coupling reaction catalyzed by transition metals. The coupling reaction occurs with 2-halogenated pyridine and iodoaromatic hydrocarbons as raw materials under the action of transition metal catalysts such as palladium catalysts. The reaction needs to be carried out under the presence of suitable ligands and bases. Commonly used bases include potassium carbonate, etc., and the ligand depends on the specific catalyst. This method can achieve the synthesis of the target product under milder conditions, and can flexibly select different halogenated pyridine and iodine aromatics to facilitate the structural modification of the product. However, the cost of the catalyst is higher, and the requirements for reaction equipment and operation are also higher. Cost factors need to be considered during large-scale production.

2-Hydroxy-5-iodopyridine is one of the organic compounds. Its physical properties are quite important and are related to the basis of many chemical applications.
Looking at its appearance, it is often white to light yellow solid powder under normal temperature and pressure. This state is convenient for storage and transportation, and is also conducive to subsequent chemical operation. Its melting point value is between 160-164 ° C. The melting point is the inherent characteristic of the substance. At this temperature, the solid and liquid states reach equilibrium, which is the key basis for identifying and purifying the substance.
In terms of solubility, 2-hydroxy-5-iodopyridine exhibits good solubility in common organic solvents such as dimethyl sulfoxide (DMSO) and N, N-dimethylformamide (DMF). This property makes it participate in many chemical reactions in solution form, promoting molecular contact and reaction. However, in water, its solubility is relatively limited. This difference is due to the difference between its molecular structure and the forces between water molecules and organic solvent molecules.
Density is also an important physical property. Although no exact value is often mentioned, it can be inferred that its density is slightly higher than that of water according to its molecular composition and the law of similar compounds. The knowledge of density is crucial when it involves operations such as phase separation and material mixing ratio.
Furthermore, its stability cannot be ignored. Under conventional environmental conditions, 2-hydroxy-5-iodopyridine has certain stability. In case of extreme chemical environments such as strong oxidants and strong acids and bases, its structure or biological changes, triggering chemical reactions and causing material transformation.
In summary, the physical properties of 2-hydroxy-5-iodopyridine, such as appearance, melting point, solubility, density and stability, are of great significance in organic synthesis, drug development and other fields, laying the foundation for chemists to use this substance.

I don't know the market price of 2-hydroxy-5-iodopyridine. Market prices often change over time, and are related to factors such as supply, quality, and purchase quantity. If you want to know the exact price, you should go to the market where the chemical is traded, the e-commerce platform, or the chemical product supplier. They can tell you a detailed price according to the current situation. Or refer to the records of past transactions, or you can get a glimpse of the approximate trend of its price. However, it is difficult to determine its exact value, because the market is fickle, and only by inquiring can you get an accurate price.

2-Hydroxy-5-iodopyridine is a chemical substance. During storage and transportation, many matters need to be paid attention to.
When storing, the first environment is dry. If this substance encounters moisture, or causes moisture degradation, its quality will be damaged. It should be placed in a dry and well-ventilated place, away from water sources and places with high humidity. In addition, temperature is also critical. It should be stored in a cool place to avoid high temperatures. Due to high temperatures or changes in its chemical properties, it may even cause reactions such as decomposition. In addition, it needs to be isolated from oxidizing and reducing substances. 2-Hydroxy-5-iodopyridine has specific chemical activities and is in contact with oxidizing or reducing substances, or reacts violently, endangering safety.
In terms of transportation, the packaging must be stable. Suitable packaging materials need to be selected to ensure that the packaging will not be damaged due to vibration, collision, etc. during transportation, and the material will leak. And the transportation vehicle also has requirements, it should be clean and dry, and there should be no other substances that may react with it. Transport personnel should also be familiar with its characteristics and emergency treatment methods. If there is a leak during transportation, it can be dealt with in a timely and correct manner to avoid the expansion of harm. In short, the storage and transportation of 2-hydroxy-5-iodopyridine must be handled with caution and strictly abide by relevant regulations to ensure safety and quality.