2-Hydroxy-5-iodo-6-methylpyridine

2-Hydroxy-5-iodine-6-methylpyridine is an organic compound. Its chemical properties are unique and valuable to explore.
As far as acidity is concerned, this compound is weakly acidic because it contains hydroxyl groups, and the hydrogen atoms of the hydroxyl groups can be dissociated to a certain extent. In the presence of a suitable base, the hydrogen of the hydroxyl group can be captured by the base to form the corresponding salt.
When it comes to nucleophilic substitution, the 5-iodine atom introduces an active check point for the molecule. As a good leaving group, the iodine atom is easily attacked by nucleophiles, and then nucleophilic substitution reactions occur. Nucleophiles can combine with iodine-containing carbon atoms by virtue of their electron-rich properties, prompting iodine ions to leave, thereby realizing the formation of replacement products.
In terms of redox reactions, some chemical bonds or atoms in molecules have the potential to undergo redox reactions. For example, hydroxyl groups can be oxidized to higher valence oxygen-containing functional groups such as carbonyl groups under the action of suitable oxidants; while the part of the pyridine ring can be hydrogenated and reduced under specific reduction conditions, resulting in changes in the structure of the pyridine ring and the distribution of the electron cloud.
Looking at its stability, the specific chemical bonds and spatial arrangements formed between the atoms in the molecular structure endow the compound with certain stability. However, due to the relative reactivity of iodine atoms, its existence will also have a certain impact on the overall stability. When exposed to high temperature, strong light or a specific chemical environment, the molecule may decompose or undergo other chemical reactions.
As for its solubility, due to both polar hydroxyl groups and non-polar pyridine rings and methyl groups, the solubility in organic solvents and water shows a certain selectivity. In polar organic solvents such as ethanol, acetone, etc., or show good solubility; in water, due to the formation of hydrogen bonds between polar parts and water molecules, there will also be a certain solubility, but due to the existence of non-polar parts, the solubility may be limited. In conclusion, the chemical properties of 2-hydroxy-5-iodine-6-methylpyridine are rich and diverse, and it has potential application value in many fields such as organic synthesis and medicinal chemistry. Its unique structure and properties provide a broad exploration space for chemical research and practical applications.

2-Hydroxy-5-iodine-6-methylpyridine is an organic compound that has important uses in many fields.
In the field of medicinal chemistry, it is often a key intermediate, which can be used to synthesize drug molecules with specific biological activities. For example, by modifying its structure, compounds with high affinity to specific biological targets can be constructed, and then therapeutics for specific diseases can be developed. Due to the presence of pyridine rings and hydroxyl groups, iodine atoms, and methyl groups, this compound is endowed with unique chemical properties and spatial structure, which is conducive to interacting with receptors or enzymes in organisms and exhibits potential pharmacological activities.
In the field of materials science, 2-hydroxy-5-iodine-6-methylpyridine can participate in the synthesis of functional materials. For example, in the preparation of organic optoelectronic materials, it can be introduced as a structural unit to adjust the electronic structure and optical properties of materials. With the heavy atom effect of iodine atoms and the conjugation system of pyridine rings, it may improve the luminous efficiency and charge transport properties of materials, providing new avenues for the research and development of organic Light Emitting Diodes (OLEDs), solar cells and other materials.
In the field of organic synthetic chemistry, it is an important synthetic block. Due to its functional groups, it can participate in various chemical reactions, such as esterification and etherification of hydroxyl groups, nucleophilic substitution and coupling reactions of iodine atoms. By rationally designing the reaction route, 2-hydroxy-5-iodine-6-methylpyridine can be used to construct complex organic molecular structures, enrich the types of organic compounds, and promote the development of organic synthesis chemistry.

To prepare 2-hydroxy-5-iodine-6-methylpyridine, the following method can be followed.
First, 6-methylpyridine-2-ol is used as the starting material. This raw material is first protected by the step of protecting the hydroxyl group. Due to the high activity of the hydroxyl group, it is prone to side reactions in subsequent reactions, so it needs to be protected. Usually, an appropriate protecting group, such as tert-butyl dimethylsilyl (TBDMS), is used in an anhydrous environment with imidazole as the base to react with 6-methylpyridine-2-ol to form 6-methylpyridine derivatives with protected hydroxyl groups.
Next, the product of the protected hydroxyl group is iodized. The iodine element is used as the iodizing agent, and the reaction is heated and stirred in a suitable organic solvent (such as N, N-dimethylformamide, DMF) in the presence of a suitable catalyst, such as copper salt (such as cuprous iodide). Iodine atoms are selectively introduced at the 5th position of the pyridine ring to obtain 5-iodine-6-methyl-2 - (tert-butyl dimethylsiloxy) pyridine.
Finally, the protective group is removed to restore the hydroxyl group. Using reagents such as tetrabutylammonium fluoride (TBAF) in tetrahydrofuran (THF) solvent, the tert-butyl dimethylsilyl protecting group can be gently removed to obtain the target product 2-hydroxy-5-iodine-6-methylpyridine. The whole process needs to pay attention to the precise control of reaction conditions, such as temperature, reaction time, reagent dosage, etc., and the product needs to be properly separated and purified after each step of the reaction to ensure the purity and yield of the final product.

What you are asking about is the market price of 2-hydroxy-5-iodine-6-methylpyridine. However, the price of this compound is difficult to determine, and it is affected by many factors.
First, the cost of raw materials has a great impact. To prepare this pyridine derivative, the price fluctuation of the raw materials required is directly related to its final selling price. If the raw materials are scarce or difficult to prepare, the cost will rise, and the product price will also rise.
Second, the simplicity and advanced level of the production process are also key. Sophisticated and efficient processes can improve production efficiency, reduce energy consumption and waste output, and thereby reduce production costs. On the contrary, the process is crude, not only the output is limited, but the cost will remain high.
Third, the market supply and demand situation has a deep impact on the price. If the market demand for this compound is strong and the supply is limited, the merchant may raise the price to gain huge profits. On the contrary, if the supply exceeds the demand, the price will inevitably decline.
Fourth, the manufacturer's brand and product quality also play a role. Well-known manufacturers have strict quality control and good reputation, and their products may be priced slightly higher. And the prices of products of uneven quality may vary greatly.
Furthermore, the sales regions and channels are different, and the prices are also different. In areas with inconvenient transportation and high logistics costs, the prices may be slightly higher. And direct sales and sales through multi-level distributors, the prices will also be different.
As for the exact price, it can only be obtained by consulting the chemical product trading platform, consulting the chemical raw material supplier, or referring to the relevant market survey report. This compound is not commonly available, and the price inquiry requires careful consideration of multiple information.

2-Hydroxy-5-iodine-6-methylpyridine is an organic compound. When storing and transporting, pay attention to the following things:
First, when storing, choose a dry, cool and well-ventilated place. If this compound is damp or deteriorated due to water vapor erosion, it will affect its quality and performance. And the high temperature environment or cause chemical reactions, resulting in damage to its stability, so a cool environment is indispensable. Well ventilated can avoid the accumulation of volatile gas and reduce safety hazards.
Second, it should be stored separately from oxidants, acids, alkalis and other substances. Because of its active chemical properties, contact with the above substances may cause severe chemical reactions, causing serious consequences such as combustion and explosion. If the oxidizing agent has strong oxidizing properties, it will meet with it or oxidize the compound, causing the reaction to go out of control.
Third, the storage container must be tightly sealed. One is to prevent volatilization, resulting in reduced content and environmental pollution; the second is to avoid reactions with air components, such as oxygen, carbon dioxide, etc., to ensure its chemical stability. Usually it is appropriate to use glass or specific plastic containers, because of their good chemical stability, it is not easy to interact with compounds.
Fourth, during transportation, ensure that the container is fixed and stable to avoid collision and vibration. Violent collision and vibration or cause the container to break and the compound to leak. And the transportation tool needs to be clean and dry, and there are no impurities that may react with it.
Fifth, transportation and storage personnel should be professionally trained and familiar with the characteristics, hazards and emergency treatment methods of the compound. In case of leakage and other accidents, they can respond quickly and correctly to reduce harm.