2-Hydroxy-5-Iodo-3-(trifluoromethyl)pyridine

2-Hydroxy-5-iodine-3- (trifluoromethyl) pyridine, an organic compound, has important uses in many fields.
First, in the field of medicinal chemistry, it is often used as a key intermediate. By modifying and transforming its specific structure, drug molecules with unique physiological activities can be synthesized. For example, for some specific disease targets, chemically synthesized into drug structures can precisely regulate the interaction between drugs and biomacromolecules, thereby improving drug efficacy and reducing toxic and side effects. This provides a key possibility for the creation of new drugs to overcome major disease problems such as cancer and cardiovascular diseases.
Second, in the field of pesticide research and development, the compound also plays a role that cannot be ignored. It can be used as a starting material for the synthesis of high-efficiency, low-toxicity and environmentally friendly pesticides. After rational design and reaction, pesticides are endowed with excellent insecticidal, bactericidal or herbicidal properties, providing strong support for sustainable agricultural development, helping to reduce the use of traditional highly toxic pesticides and reduce the harm to the ecological environment.
Third, in the field of materials science, 2-hydroxy-5-iodine-3- (trifluoromethyl) pyridine can be used to prepare functional organic materials. Due to its unique electronic structure and chemical properties, materials can impart special properties such as optics and electricity. For example, in organic Light Emitting Diode (OLED) materials, the addition of such compounds is expected to improve the luminous efficiency and stability of the material, and promote the progress of display technology.
Fourth, as an important building block of organic synthetic chemistry, it can participate in a variety of organic reactions, such as nucleophilic substitution, coupling reactions, etc. Chemists can use their structural characteristics to construct complex and diverse organic molecular skeletons by ingeniously designing reaction paths, expanding new directions for the development of organic synthetic chemistry, and enriching the variety and structural diversity of compounds.

The synthesis method of 2-hydroxy-5-iodine-3- (trifluoromethyl) pyridine has been described in many books in the past, but it is detailed below.
First, the compound containing the pyridine ring is used as the starting material. Often select suitable pyridine derivatives, which have modifiable groups at specific positions in the pyridine ring, which is the key. Through halogenation reaction, the iodine atom is precisely introduced into the fifth position of the pyridine ring. The halogenation method can choose the iodine source and reaction conditions according to the specific situation. For example, the iodine element and suitable oxidant are used to react in the appropriate solvent and temperature, so that the iodine atom successfully replaces the hydrogen atom in the corresponding position.
Then, trifluoromethyl is introduced. This step can be achieved by nucleophilic substitution or other suitable reaction paths. For example, the use of reagents containing trifluoromethyl groups, in the presence of bases or catalysts, reacts with halogenated pyridine derivatives to connect the trifluoromethyl group to the third position of the pyridine ring.
Furthermore, regarding the introduction of hydroxyl groups. Or reserve groups that can be converted into hydroxyl groups in the design of starting materials, such as halogen atoms or ester groups, and then convert them into hydroxyl groups by hydrolysis or other reactions; or at a suitable stage, use nucleophilic substitution reactions to directly connect the hydroxyl group to the second position of the pyridine ring.
The whole process of synthesis requires strict control of the reaction conditions, such as temperature, reaction time, and the proportion of reactants. And after each step of the reaction, the product needs to be finely purified by means such as column chromatography and recrystallization to ensure the smooth progress of the reaction and the purity of the product. In this way, the target product 2-hydroxy-5-iodine-3 - (trifluoromethyl) pyridine can be obtained.

2-Hydroxy-5-iodine-3- (trifluoromethyl) pyridine, this is an organic compound. Its physical properties are crucial and related to many practical applications.
First, the appearance, under room temperature and pressure, often takes a solid form, and its color may be white to light yellow powder, which is easy to identify intuitively.
The melting point is measured at about 160-165 ° C. This value is the key parameter that controls the thermal stability and phase transition of the compound. When the external temperature gradually rises to the melting point, the compound gradually melts from a solid state to a liquid state.
The value of the boiling point, under specific pressure conditions, is about 280-285 ° C. This temperature characterizes the energy required for the compound to change from liquid to gaseous state, and is of great significance for its distillation and separation operations.
In terms of solubility, this compound exhibits certain solubility in organic solvents. Common organic solvents such as dichloromethane, N, N-dimethylformamide (DMF) have good solubility in it, allowing it to be uniformly dispersed. However, the solubility in water is very small, because its molecular structure contains hydrophobic groups such as fluorine and iodine, which interact weakly with water molecules. < Br >
The determination of density is about 2.0 - 2.2 g/cm ³. This parameter is indispensable in the metering, mixing and other operations of the compound, and is related to the accurate ratio of the reaction system.
In addition, the stability of the compound is also an important physical property. In a dry environment at room temperature, it can exist relatively stably; but in case of high temperature, humidity or strong light irradiation, the molecular structure may change, which affects its chemical activity and application effect.
In summary, the physical properties of 2-hydroxy-5-iodine-3- (trifluoromethyl) pyridine, such as appearance, melting point, boiling point, solubility, density, and stability, play a crucial guiding role in its application in organic synthesis, drug development, and other fields.

When storing 2-hydroxy-5-iodine-3- (trifluoromethyl) pyridine, there are several points to pay attention to.
The first thing to pay attention to is the control of its temperature and humidity. This compound is quite sensitive to temperature and humidity, and high temperature is easy to cause it to decompose and deteriorate, and high humidity may cause it to deliquescent. Therefore, it should be stored in a cool, dry place, the temperature should be controlled between 15 ° C and 25 ° C, and the relative humidity should be kept at 40% to 60%.
For the second time, light is also the key. This product is exposed to light or has a photochemical reaction, which damages its chemical structure and quality. When stored in an opaque container or in a dark place. < Br >
In addition, its chemical properties are lively and easy to react with other substances. When storing, do not store with strong oxidants, strong alkalis, etc., to prevent unexpected chemical reactions, resulting in failure or safety. And it is necessary to keep a distance from fire and heat sources, because it has certain flammability.
In addition, the tightness of the packaging should not be ignored. Tight packaging can prevent air, moisture and impurities from invading, and maintain its purity and stability. After taking it, it should be sealed immediately to prevent it from being exposed to the air for a long time.
During storage, it should also be checked regularly. Observe whether its appearance changes, such as discoloration and agglomeration; measure its purity and content, and check whether it has deteriorated. If there is any abnormality, deal with it quickly to avoid greater losses.

2-Hydroxy-5-Iodo-3- (trifluoromethyl) pyridine is 2-hydroxy-5-iodine-3- (trifluoromethyl) pyridine. The price of this product in the market is difficult to determine. The change in its price depends on many factors.
First, the supply and demand of materials determine its price. If there are many people in the market for this product, but there are few suppliers, the price will tend to increase; conversely, if the supply exceeds the demand, the price may drop.
Second, the difficulty of preparation is also the key. The preparation of this product may require cumbersome methods, and the materials used may be rare. If the preparation method is simple and the materials used are ordinary, the price may be slightly lower.
Third, the competition in the market also has an impact. If there are many such products in the market, each competing for a share, or the price may be reduced; if there are few producers and the trend of monopoly is gradually established, the price may be stable and high.
Looking at the market conditions in the past, the price of similar compounds may be low or a few yuan per gram, high or hundreds of yuan per gram, or even more. However, 2-hydroxy-5-iodine-3- (trifluoromethyl) pyridine, due to its special structure, narrow or special application field, price or fluctuation between tens of yuan to hundreds of yuan per gram. However, this is only an idea. If you want to know the exact price, you can get the actual price by consulting the chemical raw material supplier, reagent seller, or checking in detail on the chemical trading platform.