2-Hydroxy-5-chloropyridine

2-Hydroxy-5-chloropyridine is one of the organic compounds and has a wide range of uses in the chemical industry, medicine and other fields.
In the chemical industry, it is often a key intermediate in the synthesis of other complex organic compounds. Through specific chemical reactions, it can interact with a variety of reagents to build multiple chemical structures. For example, in the preparation of some fine chemicals, with its unique molecular structure, it can endow the product with specific chemical properties and functions, such as participating in the construction of compounds with special stability or reactivity, which is of great significance to the performance improvement and diversification of chemical products.
In the field of medicine, the role of 2-hydroxy-5-chloropyridine should not be underestimated. Due to its chemical properties, it can be used as an important starting material or key structural fragment for drug synthesis. In the process of many drug development, researchers use structural modification and modification to develop new drugs with specific pharmacological activities. For example, in the creation of some antibacterial and anti-inflammatory drugs, 2-hydroxy-5-chloropyridine may be an indispensable component, which helps to enhance the affinity and biological activity of the drug to specific targets, thereby enhancing the efficacy of the drug.
In summary, 2-hydroxy-5-chloropyridine plays a crucial role in the development of today's chemical-related industries due to its wide range of uses in the chemical and pharmaceutical fields.

2-Hydroxy-5-chloropyridine is one of the organic compounds. Its physical properties are very important and are of significance in chemical research and practical applications.
First of all, under normal temperature, 2-hydroxy-5-chloropyridine is mostly in a solid state. Looking at its appearance, it is usually a white to light yellow crystalline powder. The characterization of this color state can help chemists to infer its purity and characteristics during preliminary observation.
Furthermore, the melting point is about 150-155 ° C. The melting point is the temperature at which a substance changes from a solid state to a liquid state. This specific melting point value provides a key basis for identifying the compound. If the measured melting point deviates too much from the known value, it suggests that the sample may contain impurities, or it is not pure 2-hydroxy-5-chloropyridine.
Its solubility is also worthy of attention. The solubility of the compound in water is limited, but it exhibits good solubility in organic solvents such as ethanol and acetone. This solubility property has applications in chemical synthesis, separation and purification, and preparation. For example, in the process of product separation after chemical synthesis, a suitable solvent can be selected for extraction according to its solubility difference in different solvents to achieve the purpose of purification.
In addition, 2-hydroxy-5-chloropyridine has certain stability, but its structure may change under extreme conditions such as strong acid, strong base or high temperature. Knowing this stability characteristic, chemists can take appropriate measures to avoid deterioration due to improper conditions when storing and using the compound, so as to ensure the accuracy of experimental results and the stability of product quality.
The above physical properties, such as appearance, melting point, solubility and stability, are interrelated and affect each other, and together constitute a unique physical property system of 2-hydroxy-5-chloropyridine, which lays the foundation for its research and application in the field of chemistry.

The synthesis method of 2-hydroxy-5-chloropyridine has been known for a long time. There are three methods, let me tell you one by one.
First, 5-chloro-2-methoxypyridine is used as the starting material. This is a classic method. First, 5-chloro-2-methoxypyridine is reacted with a strong base, such as sodium hydroxide or potassium hydroxide, at high temperature and in a suitable solvent. In the meantime, the methoxy group is replaced by a hydroxyl nucleophilic group to give rise to 2-hydroxy-5-chloropyridine. For example, when dimethyl sulfoxide is used as a solvent and heated to 150-180 ° C, the reaction number can be obtained. This process requires strict temperature control, and the solvent needs to be dried and anhydrous to prevent side reactions.
Second, 2,5-dichloropyridine is used as the raw material. This is also a common method. React 2,5-dichloropyridine with a nucleophile, such as sodium methoxide, in a suitable solvent, such as methanol, and the monochloride is replaced by a methoxy group. Then, it is hydrolyzed, treated with a strong acid, such as hydrochloric acid, under heating conditions, and the methoxy group is replaced by a hydroxyl group to obtain 2-hydroxy-5-chloropyridine. This hydrolysis step is crucial, and the concentration of the acid, the reaction temperature and time need to be carefully controlled to obtain a high-purity product.
Third, 2-hydroxypyridine is used as the starting material. 2-hydroxypyridine is first chlorinated. It is often reacted with chlorine gas or chlorine-containing reagents, such as phosphorus oxychloride and phosphorus pentachloride, in the presence of suitable catalysts, such as aluminum trichloride. When chlorine atoms are introduced at the 5th position of the pyridine ring, 2-hydroxy- 5-chloropyridine is obtained. In this process, the amount of catalyst, the reaction temperature and the drip acceleration of the chlorination reagent all have a great influence on the yield and purity of the product, so caution is required during operation.
The three methods for synthesizing 2-hydroxy-5-chloropyridine have their own advantages and disadvantages, and they need to be carefully selected according to specific circumstances, such as raw material availability, cost, and product purity requirements.

The price of 2-hydroxy-5-chloropyridine in the market is difficult to determine. The change in its price depends on multiple ends. First, the trend of supply and demand is extremely serious. If there are many people who want it, but the supply is small, the price will rise; on the contrary, if the supply exceeds the demand, the price may drop. Second, the cost of the system is also a major factor. The price of raw materials, labor costs, equipment consumption, etc., can all affect its cost, and then affect its price. Furthermore, the competition of the city and the regulations of the government also affect the price.
Looking at the past, the chemical industry market is changeable. However, if you want to know the exact price of 2-hydroxy-5-chloropyridine, you must visit the chemical industry, the structure of the market, or the price stated by the platform of the chemical industry. Generally speaking, the price may vary according to the quality and the quantity. High-quality and large-scale purchases, the price may be given; inferior quality and small quantities, the price may be higher. And in different places, due to differences in freight and taxes, the price also varies. Therefore, if you want to know the cut price, you must carefully observe the market situation and seek information from many parties before you can get a more accurate number.

2-Hydroxy-5-chloropyridine is an organic compound, and its storage conditions are crucial to the stability and quality of this compound. Store in a cool, dry and well-ventilated place.
A cool environment can reduce its chemical reaction caused by excessive temperature. If the temperature is high, or the molecular activity is greatly increased, it will trigger decomposition, polymerization and other reactions, which will damage its chemical structure and damage its quality. Therefore, it is quite important to avoid direct sunlight and be in a relatively low and stable place.
Dry conditions are also indispensable. Water vapor in the air can react with 2-hydroxy-5-chloropyridine, or cause it to absorb moisture and dissolve, or promote hydrolysis. If this compound wades in water, or causes groups such as hydroxyl groups and chlorine atoms to change, its chemical properties will be changed, and its purity and effectiveness will be reduced. Therefore, the storage place must be moisture-proof, and a desiccant can be placed next to it to absorb the surrounding water vapor.
Good ventilation can ensure air circulation in the storage environment. If the air does not flow, the gases evaporated by the compound may gather in one place, increasing the risk of explosion and poisoning. And ventilation can dissipate the heat generated by the chemical reaction and prevent local overheating.
In addition, 2-hydroxy-5-chloropyridine should be separated from oxidizing agents, acids, alkalis and other substances. Due to its specific chemical properties, contact with these substances, or violent reaction, can cause serious consequences such as fire and explosion.
Storage containers also need to be carefully selected. Corrosive-resistant materials, such as glass, specific plastics, etc. Glass containers are chemically stable and do not react easily with compounds; some special plastics can also resist corrosion and protect compounds from the material of the container. And the container needs to be tightly sealed to prevent air, water vapor and other intrusion.