2 Hydroxy 4 Pyridinecarboxaldehyde
pyridine pyrrole pyrazine piperidine piperazine

2-HYDROXY-4-PYRIDINECARBOXALDEHYDE

    Specifications

    HS Code

    322201

    Name 2-HYDROXY-4-PYRIDINECARBOXALDEHYDE
    Molecular Formula C6H5NO2
    Molar Mass 123.11 g/mol
    Physical State At Room Temperature Solid
    Solubility In Water Moderate to low (due to polar groups but also hydrophobic part of the pyridine ring)
    Solubility In Organic Solvents Soluble in polar organic solvents like ethanol, methanol
    Pka For Phenolic Oh Around 10 - 11 (typical for phenolic -OH groups in similar aromatic compounds)
    Reactivity Reactive towards nucleophiles at the aldehyde group and can participate in reactions typical for phenols

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    Frequently Asked Questions

    As a leading 2-HYDROXY-4-PYRIDINECARBOXALDEHYDE supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the chemical properties of 2-HYDROXY-4-PYRIDINECARBOXALDEHYDE?
    2-Hydroxy-4-pyridyl formaldehyde, this is an organic compound. Its chemical properties are unique and of great significance in the field of organic synthesis.
    Let's talk about its physical properties first. At room temperature, or in a solid state, it has a specific melting point and boiling point. However, the exact value needs to be determined by precise experiments. Its solubility is also a key property. In common organic solvents, such as ethanol and dichloromethane, it may show some solubility, while in water, it may be relatively limited, which is related to the polar groups in the molecule.
    In terms of chemical properties, the presence of aldehyde groups gives it many typical reactivity. The aldehyde group can undergo oxidation reaction. When it encounters a strong oxidant, such as potassium permanganate, it can be oxidized to a carboxyl group to obtain 2-hydroxy-4-pyridinecarboxylic acid; if it is treated with a weak oxidant, such as Torun's reagent or Feilin's reagent, a silver mirror reaction can occur or a brick-red precipitation can be formed. This is a characteristic reaction of aldehyde groups and is often used in the identification of aldehyde compounds.
    At the same time, aldehyde groups can also undergo reduction reactions. With suitable reducing agents, such as sodium borohydride, aldehyde groups can be reduced to hydroxyl groups to obtain 2-hydroxy-4-pyridinecanol. Furthermore, aldehyde groups can undergo condensation reactions with compounds containing active hydrogen, such as with amine compounds, under appropriate conditions, Schiff bases can be formed.
    The presence of hydroxyl groups also adds a different reactivity to the compound. Hydroxyl groups can undergo esterification reactions, and under the action of catalysts with carboxylic acids or acyl chlorides, corresponding esters are formed. In addition, hydroxyl groups can also participate in intramolecular or intermolecular hydrogen bonding, which has a significant impact on their physical properties, such as melting point, boiling point, and solubility.
    Due to the presence of a conjugated system of pyridine rings, the compound also has certain aromaticity. Under certain conditions, electrophilic substitution reactions can occur, substituting check points or being affected by the positioning effects of hydroxyl groups and aldehyde groups. In conclusion, the various chemical properties of 2-hydroxy-4-pyridyl formaldehyde make it have potential application value in many fields such as drug synthesis and materials science.
    What are the main uses of 2-HYDROXY-4-PYRIDINECARBOXALDEHYDE?
    2-Hydroxy-4-pyridyl formaldehyde has a wide range of uses. In the field of medicine, it can be used as a key intermediate to help synthesize drugs with specific pharmacological activities. Due to the molecular structure containing hydroxyl and aldehyde groups, it is endowed with unique chemical activity and can react with many reagents to build complex drug molecular structures, laying the foundation for the development of new drugs for the treatment of various diseases.
    In the field of materials science, 2-hydroxy-4-pyridyl formaldehyde can be used to prepare functional materials. For example, it can coordinate with metal ions to form complexes with special optical, electrical or magnetic properties, which show potential application value in luminescent materials, sensor materials, etc. Because of its combination with metal ions, the structure and properties will change, which can realize the detection and response of specific substances or physical quantities.
    In the field of organic synthesis, 2-hydroxy-4-pyridyl formaldehyde is also an important raw material. With its active functional groups, it can participate in many organic reactions, such as condensation reactions, oxidation-reduction reactions, etc., used to synthesize organic compounds with diverse structures, enrich the variety of organic compounds, and provide more possibilities for the development of organic synthesis chemistry.
    In addition, in the preparation of some fine chemicals, 2-hydroxy-4-pyridyl formaldehyde also plays an indispensable role in promoting the progress of related fine chemical industries.
    What are 2-HYDROXY-4-PYRIDINECARBOXALDEHYDE synthesis methods?
    To prepare 2-hydroxy-4-pyridine formaldehyde, there are various methods. One is to start with the corresponding pyridine derivative and obtain it by a specific chemical reaction. First, take a suitable pyridine compound, put it in a suitable reaction vessel, and prepare the corresponding reaction system, which contains a specific solvent, catalyst, etc. If an organic solvent is selected, it can accommodate the substrate and help the reaction proceed. The choice of catalyst is also critical, which can promote the reaction rate and change the reaction path.
    When reacting, adjust to the appropriate temperature and pressure. Temperature is related to the reaction rate and product selectivity, or it needs to be heated to increase the molecular activity and collide frequently, which is conducive to chemical bond breaking and formation. The pressure is maintained at normal pressure, or adjusted according to the needs of the reaction. By means of a heating device, such as an oil bath or a water bath, the temperature is stabilized at the set value.
    The second can be converted from another related compound through a series of conversions. The starting compound is modified first, and the necessary functional groups are introduced, and then the functional group conversion reaction is carried out. Each step of the reaction requires careful control of conditions, such as reaction time and the proportion of reactants. If the reaction time is too long or side reactions are increased, the purity of the product will decrease; if the proportion is not correct, it will also affect the yield.
    During operation, a variety of analytical methods are required to monitor the progress of the reaction. For example, by thin-layer chromatography, the reaction liquid spot plate is taken regularly, and the consumption and product generation are known according to the position and color of the spots. Gas chromatography, liquid chromatography, etc. can also be used to obtain more accurate < Br >
    When the reaction is as expected, the product should be treated by a suitable method. Or by extraction, the solvent that is not miscible with the reaction system is selected to extract the product. After distillation, recrystallization and other purification steps, impurities are removed, and the purity of the product is improved to obtain pure 2-hydroxy-4-pyridine formaldehyde.
    What is the market price of 2-HYDROXY-4-PYRIDINECARBOXALDEHYDE?
    2-Hydroxy-4-pyridyl formaldehyde, this is an organic compound. As for its market price, it varies due to many factors, and it is difficult to say exactly.
    First, the purity of the product has a great impact on the price. If the purity is extremely high, reaching the level of scientific research, and there are very few impurities, it can be used for high-end experimental research, and its price must be high. Because of the complex purification process, it requires fine technology and high-end equipment, and the cost increases greatly. However, if the purity only meets general industrial use, the price will be relatively low.
    Second, the market supply and demand situation also affects the price. If the demand for 2-hydroxy-4-pyridyl formaldehyde increases sharply at a certain time, if the pharmaceutical industry needs a large amount of this compound to develop new drugs, and the supply is limited, its price will rise. On the contrary, if the supply exceeds the demand, the manufacturer will sell it for promotion, and the price may drop.
    Third, the manufacturer and the origin also have an impact. Different manufacturers have different technical levels and production costs. Manufacturers with advanced technology and good cost control may have more competitive product prices. And different origins have different transportation costs. When products from remote origins are shipped to the market, the price may increase due to transportation costs.
    Fourth, the international economic situation is also related to the price of raw materials. If the global economy is unstable, or the price of raw materials for the production of 2-hydroxy-4-pyridyl formaldehyde fluctuates, the price will change. Raw material prices rise, product costs increase, and prices will also rise.
    Therefore, in order to know the exact market price of 2-hydroxy-4-pyridyl formaldehyde, it is necessary to carefully check the product specifications, purity, and actual market supply and demand at that time, and inquire from relevant chemical product suppliers and distributors, or refer to the price information of professional chemical product trading platforms to obtain more accurate prices.
    What 2-HYDROXY-4-PYRIDINECARBOXALDEHYDE need to pay attention to when storing and transporting
    2-Hydroxy-4-pyridyl formaldehyde, an organic compound, requires special attention to many key points during storage and transportation.
    The first thing to pay attention to is temperature control. This compound is quite sensitive to temperature, and high temperature is easy to cause it to deteriorate. Therefore, it should be stored in a cool place, and the temperature should be maintained between 15 and 25 degrees Celsius, so as to ensure the stability of its chemical properties. When transporting, it is also necessary to avoid high temperature environment. If transporting in summer, effective cooling measures need to be taken, such as using refrigerated trucks.
    The second is to prevent humidity. Because of its certain water absorption, it may cause chemical reactions after being damp, resulting in quality damage. The storage place must be dry, and the humidity should be controlled at 40% to 60%. During transportation, the packaging must be tight to prevent the intrusion of external moisture. A desiccant can be placed in the package to absorb moisture.
    In addition, the avoidance of light is also the key. Light may accelerate its decomposition. When storing, it should be placed in a dark place and packed in an opaque container. During transportation, it is also necessary to prevent direct sunlight. Light-shielding materials can be used to cover the transportation vehicle.
    In addition, the strength of the packaging is indispensable. 2-Hydroxy-4-pyridyl formaldehyde may be corrosive to a certain extent, and the packaging material must be compatible with it and strong enough to prevent leakage during storage and transportation. At the same time, the warning label should be clearly marked on the outside of the package to remind the operator to be careful.
    When storing and transporting, it should also be separated from other chemicals to avoid reaction with them. Operators should also have professional knowledge and strictly follow the operating procedures, so as to ensure the safety and stability of 2-hydroxy-4-pyridine formaldehyde during storage and transportation.