2 Hydroxy 4 Chloropyridine
pyridine pyrrole pyrazine piperidine piperazine

2-Hydroxy-4-chloropyridine

    Specifications

    HS Code

    174610

    Chemical Formula C5H4ClNO
    Molar Mass 129.544 g/mol
    Appearance Solid (usually white or off - white)
    Odor Typically has a characteristic pyridine - like odor
    Solubility In Water Moderately soluble
    Melting Point 128 - 132 °C
    Boiling Point Decomposes before boiling under normal conditions
    Density Approximately 1.35 g/cm³
    Pka Around 3.5 - 4.5 (indicative of acidic nature due to the hydroxy group)

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    General Information
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    Frequently Asked Questions

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    What are the physical properties of 2-Hydroxy-4-chloropyridine?
    2-Hydroxy-4-chloropyridine is also an organic compound. Its physical properties are particularly important, related to its performance in various chemical processes and practical applications.
    First of all, its appearance is often white to light yellow crystalline powder. This form is easy to store, transport and access, and reflects the characteristics of its molecular arrangement and aggregation.
    The melting point is between 136 and 140 ° C. The melting point is one of the properties of the substance. At this temperature, the solid state of 2-hydroxy-4-chloropyridine can be converted into a liquid state. This value is an important basis for the identification of the compound, and in separation, purification and other operations, the determination of the melting point is helpful to judge its purity.
    Solubility is also a key property. It is slightly soluble in water, but in organic solvents such as ethanol and acetone, it has good solubility. This property is derived from the influence of hydroxyl groups and chlorine atoms in its molecular structure. Hydroxyl groups can form hydrogen bonds with some organic solvents to enhance solubility. The presence of chlorine atoms makes the molecule have a certain polarity, which affects its interaction with different solvents.
    Furthermore, its density is about 1.48 g/cm ³. The density reflects the mass per unit volume of a substance. In chemical production, product formulation design, etc., density data is essential for accurate measurement and mixing of materials. < Br >
    In addition, due to the presence of pyridine rings, hydroxyl groups and chlorine atoms in its molecular structure, it is endowed with certain stability. However, under certain conditions, such as high temperature, strong acid and alkali environment, chemical reactions will also occur, which is related to the strength and activity of the chemical bonds within the molecule.
    In summary, the physical properties of 2-hydroxy-4-chloropyridine, such as appearance, melting point, solubility, density, etc., play their respective roles, and are all indispensable factors for chemical research, industrial production, and related applications.
    What are the chemical properties of 2-Hydroxy-4-chloropyridine?
    2-Hydroxy-4-chloropyridine is one of the organic compounds. Its chemical properties are unique and have many wonders.
    Looking at its structure, the hydroxyl group and the chlorine atom are located at a specific position in the pyridine ring, and this structure layout greatly affects its properties. The presence of hydroxyl groups makes the compound hydrophilic to a certain extent. The oxygen atom in the edge hydroxyl group is strong electronegativity, and it is easy to form hydrogen bonds with water molecules, so it has a certain solubility in water. And hydroxyl groups have active chemical activity and can participate in many chemical reactions. Under suitable conditions, hydroxyl groups can undergo substitution reactions, such as reacting with acyl chloride to form ester compounds. In this reaction, the hydrogen atom of the hydroxyl group is replaced by an acyl group to form new compounds with different properties.
    Furthermore, the chlorine atom is also a key structural part. Chlorine atoms have strong electron absorption, which can reduce the electron cloud density of the pyridine ring, so that the pyridine ring is more prone to electrophilic substitution. For example, under the action of a specific catalyst, it can react with electrophilic reagents and introduce other functional groups on the pyridine ring. Moreover, chlorine atoms can also participate in some elimination reactions. For example, under basic conditions, chlorine atoms can eliminate hydrogen atoms on adjacent carbon atoms to form unsaturated compounds containing double bonds.
    In addition, the pyridine ring of 2-hydroxy-4-chloropyridine itself is also aromatic, which makes it stable. The conjugated system of the pyridine ring can disperse electrons and reduce the molecular energy. This aromaticity also affects its reactivity and selectivity. In chemical reactions, the pyridine ring tends to maintain its aromatic structure, so the reaction mostly occurs at the position where the hydroxyl group and the chlorine atom are located or affected by it.
    In short, 2-hydroxy-4-chloropyridine has many chemical properties such as hydrophilicity, active substitution reactivity, electrophilic substitution properties affected by chlorine atoms, and stability based on the aromaticity of the pyridine ring. It has important applications in organic synthesis and other fields.
    What are the common synthetic methods of 2-Hydroxy-4-chloropyridine?
    2-Hydroxy-4-chloropyridine is also an organic compound. Its common synthesis method depends on various chemical techniques.
    One of them may start with 4-chloropyridine-2-one. The 4-chloropyridine-2-one can be converted into 2-hydroxy-4-chloropyridine with an appropriate halogenating agent in a suitable reaction environment and through the halogenation process. The choice of halogenating agent depends on the reaction conditions and the requirements of the product. And the reaction temperature, time, solvent, etc. are all key elements and must be carefully regulated to achieve optimum effect.
    Second, pyridine is used as the initial raw material. The pyridine is first chlorinated to obtain 4-chloropyridine. Then, 4-chloropyridine is reacted with a suitable hydroxylating agent, and through the hydroxylation step, the 2-position of 4-chloropyridine is introduced into the hydroxyl group to obtain 2-hydroxy-4-chloropyridine. In this process, the conditions of the chlorination reaction, such as the chlorination reagent used, the reaction temperature, and the presence or absence of a catalyst, all affect the yield and purity of the chlorination product. The same is true for the hydroxylation reaction. The activity of the hydroxylating reagent and the properties of the reaction medium have a great influence on the formation of the final product.
    Starting with other compounds containing pyridine structures, through a series of reactions, such as substitution, oxidation, reduction, etc., the molecular structure of 2-hydroxy-4-chloropyridine is ingeniously constructed. Although these methods have different paths, they all require careful study of each step of the reaction, clear observation of the reaction mechanism, and precise control of the reaction conditions in order to make the synthesis process smooth and obtain this target product.
    2-Hydroxy-4-chloropyridine in what areas?
    2-Hydroxy-4-chloropyridine is used in various fields. In the field of medicine, it is often the key raw material for the synthesis of drugs. Because of its unique structure, it can be combined with other compounds by chemical methods to obtain drugs with specific curative effects. For example, it can be used to develop antibacterial and anti-inflammatory drugs to help doctors heal patients.
    In the field of pesticides, 2-hydroxy-4-chloropyridine also has its own capabilities. It can be used as a basic material for the creation of new pesticides, and can be used to synthesize preparations with efficient insecticidal and herbicide functions. In this way, it can protect farmland crops from pests and diseases and weeds, and increase the yield of crops.
    Furthermore, in the field of materials science, this compound also shows its value. Or it can participate in the synthesis of special materials, giving the material different properties, such as improving the stability and corrosion resistance of the material. Therefore, 2-hydroxy-4-chloropyridine plays an important role in the innovation and optimization of materials.
    In the field of organic synthetic chemistry, it is an important intermediate. Chemists can introduce different functional groups by performing a series of reaction operations on it to construct more complex and diverse organic molecular structures. This is of great significance in the research and development process of organic chemistry, enabling researchers to explore new organic compound systems and explore unknown chemical properties and applications. In short, 2-hydroxy-4-chloropyridine is useful in many fields such as medicine, pesticides, materials science, and organic synthetic chemistry, and contributes to the progress of various sciences and technologies.
    What is the market price of 2-Hydroxy-4-chloropyridine?
    2-Hydroxy-4-chloropyridine, the price of this product in the market is difficult to determine, and it often varies with time and varies according to many conditions.
    In the past, the price of materials in the city was determined by factors such as supply and demand, origin, production method, and quality. If the quantity is large, but the output is limited, the price will be higher; the origin is remote, and the transportation is difficult, and the price will also increase; the production method is complicated, and the labor-intensive consumables are expensive; the quality is high, and the price is not low.
    However, I have searched the past records all over, but I have not obtained a definite price. Cover chemical products, the market situation is diverse, and the price is like a flow wave, which is difficult to determine. There may be past transactions, the price of which is kept secret and not widely disseminated. Or the years pass, the market changes, and the price of the past is of no great benefit today.
    Although it is difficult to know the exact price, if you want to know the current market price, you can go to the chemical material trading office, or consult the business specializing in this industry, or visit the chemical trading network. There you can often get the latest information and know the current price for weighing.