2-Hydroxy-3-Pyridine Carboxylic acid

2-Hydroxy-3-pyridinecarboxylic acid, also known as quinolinic acid, is widely used.
In the field of medicine, its importance cannot be underestimated. Quinolinic acid is a key intermediate in the synthesis of many drugs. For example, in the preparation of some nervous system drugs, it plays a cornerstone role. Because the research and development of nervous system drugs often requires the construction of specific chemical structures, quinolinic acid has unique chemical groups and reactive activities, which can skillfully introduce target molecules and help synthesize drugs with the functions of regulating neurotransmitters and improving nervous function.
In the chemical industry, it also has outstanding performance. It can be used to prepare polymer materials with unique properties. With its own chemical properties, it participates as a functional monomer in the polymerization reaction, so that the resulting polymer material has special thermal stability, chemical stability or optical properties. For example, in the development of some high-end coatings and engineering plastics, adding polymers synthesized by quinolinic acid can significantly improve product quality and performance, and meet the strict requirements of materials in different industrial scenarios.
Furthermore, in scientific research experiments, quinolinic acid is a commonly used biochemical reagent. Researchers use it to simulate specific metabolic processes or chemical reactions in living organisms, helping to further explore the chemical nature of life activities. For example, in many basic biological experiments such as cell metabolism and enzyme activity research, it serves as a key reagent, providing a powerful tool for revealing the mysteries of life and promoting the continuous expansion and update of knowledge in the field of biology.

2-Hydroxy-3-pyridinecarboxylic acid, its shape is also white to light yellow crystalline powder. Stable, can last for a long time without deterioration in conventional environments. The melting point is quite high, about 180 to 184 degrees Celsius. At this temperature, this substance gradually melts from solid to liquid. Looking at its changes, its melting point characteristics can be known.
Its solubility is unique, soluble in water, but the solubility is not very large, and it is still moderate. In hot water, the dissolution speed is faster and the amount is more. As for organic solvents, such as ethanol and acetone, there is also a certain solubility. In ethanol, it can be partially dissolved to form a uniform mixed system, depending on its concentration, either clear or slightly cloudy. < Br >
The acidity of this substance is not as strong as strong acid, but it is also acidic to a certain extent. In solution, hydrogen ions can be partially ionized, making the solution acidic. The strength of its acidity can be measured by the relevant acidity constant.
Because its structure contains active groups such as hydroxyl and carboxyl groups, it has a certain chemical activity. Hydroxyl groups can be substituted and react with reagents such as acid chlorides to form ester compounds. The activity of carboxyl groups is not weak, and can neutralize with bases to form corresponding salts. And under appropriate conditions, carboxyl groups can also participate in esterification reactions, react with alcohols to form esters, which are all important chemical properties and have considerable application value in organic synthesis and other fields.

2-Hydroxy-3-pyridinecarboxylic acid, also known as quinolinic acid, is an organic compound. Its chemical properties are unique and interesting.
As far as acidity is concerned, it is acidic because it contains carboxyl and hydroxyl groups. The carboxyl group can ionize hydrogen ions, exhibit acidic properties in water, and can neutralize with bases to form corresponding carboxylic salts and water. This reaction is like a softening, acid-base blend, to achieve a new chemical equilibrium.
When it comes to solubility, the substance is soluble in water and some polar organic solvents. Because both carboxyl and hydroxyl groups in the molecule are hydrophilic, they form hydrogen bonds with water molecules and merge into the embrace of water, just like a wanderer returning to its hometown and finding a habitat.
In terms of stability, it is relatively stable under normal conditions. In case of extreme situations such as high temperature and strong oxidants, the structure may be damaged. The high temperature is like a ruthless flame, and the strong oxidant is like a sharp blade, which may break the tranquility of its original chemical structure.
The chemical reaction of 2-hydroxy-3-pyridinecarboxylic acid is quite rich. Carboxyl groups can participate in esterification reactions, and under the action of alcohols in catalysts, such as when catalyzed by concentrated sulfuric acid and heated, esters and water are formed. This process is like a recombination dance between molecules, with each atom rearranging and combining, blooming new chemical flowers. Hydroxyl groups can also participate in many reactions, such as reacting with active metals to replace hydrogen, which is like a warrior's sword, showing unique chemical activity.
In addition, the pyridine ring of this compound gives it a special electron cloud distribution, making it possible to coordinate reactions with metal ions as a ligand to form complexes and build complex and delicate chemical structures, which have made it popular in the fields of materials science and other fields.

The preparation of 2-hydroxy-3-pyridine carboxylic acid, also known as 2-hydroxy nicotinic acid, is a key technology in the field of chemistry. In the past, this acid was prepared in several ways.
First, pyridine derivatives are used as the initial raw materials. If a specific substituted pyridine is selected, the target product can be obtained after oxidation reaction. This oxidation method often requires finding a suitable oxidant. In the past, strong oxidants were commonly used. Although they could cause reactions to occur, the selectivity was poor, and many by-products were often produced, resulting in complicated product separation and purification, and the yield was also limited.
Second, by the method of microbial transformation. Some microorganisms have specific enzyme systems and can perform biocatalytic transformation on specific substrates. Microorganisms that can act on pyridine-containing structural substrates are selected. Under suitable culture conditions, the enzyme produced by the microorganisms can catalyze the substrate and gradually convert it into 2-hydroxy-3-pyridine carboxylic acid. Although this biological method has the advantages of green and mild, the microbial culture conditions are strict, sensitive to environmental factors, and the stability and activity of the enzyme are not easy to maintain, which poses challenges for industrial application.
Third, in the chemical synthesis route, simple compounds containing hydroxyl groups and pyridine rings are also used as starting materials, and the target molecule is constructed through multi-step organic reactions. However, the reaction conditions of each step need to be precisely regulated, involving many reaction steps such as esterification, hydrolysis, substitution, etc. The variety of steps can easily reduce the overall yield, and the separation and purification operation after each step also increases the complexity of the process.
To obtain an efficient method for preparing 2-hydroxy-3-pyridinecarboxylic acid, it is necessary to weigh the advantages and disadvantages of each method, and comprehensively consider the reaction selectivity, yield, cost, environmental impact and other aspects, and continuously optimize the process. Only then can a more suitable preparation path be found.

Today, there is a question about the price range of 2-hydroxy-3-pyridinecarboxylic acid in the market. This compound, also known as 2-hydroxy nicotinic acid, is a commonly used raw material in the fields of organic synthesis and medicinal chemistry.
Looking at the records of past market transactions, its price fluctuations are often influenced by a variety of factors. First, the availability of raw materials. If the supply of starting materials for preparing this acid is abundant and the price is flat, the price of 2-hydroxy-3-pyridinecarboxylic acid will also become stable and inexpensive. Conversely, if the raw materials are scarce and need to be purchased at a high price, the price of the product will rise.
Second, the difficulty of the production process. If the synthesis path is simple and the yield is high, the cost is controllable and the price is close to the people; if the process is complicated, special equipment and reagents are required, and the yield is low, the cost is high and the price is also high.
Third, the amount of market demand. If the pharmaceutical, chemical and other industries have strong demand for this acid and the supply is in short supply, the price will rise; if the demand is low and the supply exceeds the demand, the price will fall.
In past transactions, the price of this acid ranged from a few yuan to tens of yuan per gram. If it is a crude product with slightly lower purity, the price may be around a few yuan to ten yuan per gram; if it is a high-purity boutique, it is suitable for high-end pharmaceutical research and development, and the price can reach tens of yuan per gram.
However, the market is fickle, and the state of supply and demand, the price of raw materials, and the revolution of processes can all cause their prices to fluctuate. To know the real-time price, you can get an accurate figure by consulting the latest quotations from chemical raw material suppliers, reagent sellers, or the chemical product trading platform.