2-hydroxy-3-nitro-5-(trifluoromethyl)pyridine

2-Hydroxy-3-nitro-5- (trifluoromethyl) pyridine, this substance has a wide range of uses and is very important in the field of chemical synthesis.
In the field of pharmaceutical synthesis, it is often a key intermediate. Geinpyridine compounds have unique chemical structures and activities, and can construct multiple and complex drug molecular structures through specific chemical reactions. Using this substance as a starting material, nitrification, halogenation, coupling and many other reactions can prepare a variety of bioactive compounds, which can be used to develop antibacterial, anti-inflammatory, anti-tumor and other drugs.
In the field of pesticides, 2-hydroxy-3-nitro-5- (trifluoromethyl) pyridine is also very popular. Due to its structure endowing certain insecticidal and bactericidal properties, it can be modified on the basis of it to synthesize high-efficiency, low-toxicity and environmentally friendly pesticide products. Such pesticides can effectively prevent and control crop diseases and pests, ensure the growth of crops, and improve the yield and quality of agricultural products.
In addition, in the field of materials science, it also shows unique value. With its fluorine-containing group and nitro group characteristics, it can be used to synthesize polymer materials with special properties. Such materials may have excellent thermal stability, chemical stability and electrical properties, and have broad application prospects in high-end fields such as electronic devices and aerospace.
2-Hydroxy-3-nitro-5 - (trifluoromethyl) pyridine is an indispensable and important compound in the fields of medicine, pesticides and materials science, and has made great contributions to the development of related industries.

The synthesis method of 2-hydroxy-3-nitro-5- (trifluoromethyl) pyridine, although not directly recorded in the classic "Tiangong Kaiwu", is based on ancient thinking, and can be derived from pyridine derivatives through multiple steps.
The first step is to select the appropriate parent pyridine, and introduce the nitro group with a specific reagent according to the principle of electrophilic substitution. This step requires careful selection of reaction conditions, temperature control, pressure and reagent ratio, so that the nitro group precisely falls at the designated position of the pyridine ring, covering the positioning of the nitro group, which is related to the structure of the product and the subsequent reaction trend.
The second step is to introduce trifluoromethyl at the appropriate check point of the pyridine ring. This can be achieved by a specific organic reaction with a reagent containing trifluoromethyl. This reaction is quite critical. Due to the special properties of trifluoromethyl, it can significantly change the physical and chemical properties of the compound. During operation, the reaction process must be carefully observed to prevent side reactions.
In the last step, a specific group on the pyridine ring is converted into a hydroxyl group. This may be done by nucleophilic substitution, hydrolysis, etc., according to the groups left in the previous steps and the reaction activity, the optimal path is selected. After each step of the reaction, when the delicate separation and purification method is used to remove impurities and improve the purity of the product, the pure 2-hydroxy-3-nitro-5- (trifluoromethyl) pyridine can be obtained. Although the ancient methods of synthesis may be different from those of today, the principles of chemical change are the same. Following this line of thinking, we can achieve success.

2-Hydroxy-3-nitro-5- (trifluoromethyl) pyridine is an important compound in the field of organic chemistry. Its physical properties are unique and worthy of investigation.
Looking at its appearance, it often shows a light yellow to brown solid state. This color characteristic may be due to the conjugation of nitro groups and trifluoromethyl groups in the molecule, which causes it to show a specific wavelength of light absorption and then show the corresponding color.
When it comes to the melting point, it is about 145-149 ° C. This value reflects the strength of the intermolecular force. In this temperature range, the molecule is energized enough to overcome the lattice energy, and the lattice structure disintegrates and converts from a solid state to a liquid state.
In terms of boiling point, due to the strong electron-absorbing nitro and trifluoromethyl groups in the molecule, the polarity of the molecule is greatly increased, the intermolecular force is strengthened, and the boiling point is relatively high, about 300 ° C. At this temperature, the kinetic energy of the molecule is sufficient, and it can break free from the liquid phase and become the gas phase.
Solubility is also an important physical property. This compound is slightly soluble in water because water is a strong polar solvent. Although the compound contains hydroxyl groups that can form hydrogen bonds with water, the strong hydrophobicity of nitro and trifluoromethyl groups is dominant, making it difficult to dissolve in water. However, in common organic solvents such as dichloromethane, N, N-dimethylformamide, the solubility is quite good, because these solvents and compounds can interact with each other through van der Waals forces, etc., to achieve good mutual solubility.
Its density is about 1.68 g/cm ³, indicating that the compound has a relatively large mass per unit volume, which is related to the existence of high relative atomic mass elements such as fluorine atoms in its molecular structure.
In summary, the physical properties of 2-hydroxy-3-nitro-5- (trifluoromethyl) pyridine, such as appearance, melting point, boiling point, solubility, and density, are determined by its unique molecular structure, and these properties are of great significance for its application in organic synthesis, medicinal chemistry, and other fields.

2-Hydroxy-3-nitro-5- (trifluoromethyl) pyridine, this is an organic compound with unique chemical properties.
It is acidic. Because the molecule contains hydroxyl groups, the oxygen atoms in the hydroxyl groups are highly electronegative, and the hydrogen-oxygen bond polarity is large. Hydrogen atoms are easily dissociated in the form of protons, so they are acidic. It can neutralize with bases to form corresponding salts.
Its nitro properties are active. Nitro is a strong electron-absorbing group, which decreases the electron cloud density of the pyridine ring, making the electrophilic substitution reaction on the ring more difficult, but it is easy to initiate nucleophilic substitution reaction. When encountering nucleophilic reagents, the nitro ortho or para-carbon atoms are vulnerable to attack and nucleophilic substitution occurs.
Trifluoromethyl also affects molecular properties. Trifluoromethyl has a strong electron-absorbing effect, which further reduces the electron cloud density of the pyridine ring and enhances molecular stability and chemical inertness. At the same time, due to the hydrophobicity of trifluoromethyl, it has an effect on the solubility and fat solubility of the compound, and its solubility may be better in some organic solvents.
In addition, the compound can participate in a variety of organic synthesis reactions due to its multi-functional groups. For example, compounds with more complex structures can be prepared by substitution, condensation and other reactions, which have potential application value in pharmaceutical chemistry, materials science and other fields.

2-hydroxy-3-nitro-5- (trifluoromethyl) pyridine is an organic compound, and its market price range often changes due to many factors.
Looking at the past market situation, the price of this compound is deeply influenced by multiple reasons. First, the cost of raw materials is the key factor. If raw materials are scarce or difficult to obtain, their price will increase; conversely, if raw materials are abundant and easy to obtain, the price may drop. Second, the complexity of the preparation process also has a great impact. If the process is complex, high-end technology and many steps are required, the cost will increase, resulting in a rise in prices; and simple and efficient processes may reduce costs and stabilize prices. Furthermore, the supply and demand situation of the market is particularly important. If the demand exceeds the supply, the merchant may raise the price to obtain a large profit; if the supply exceeds the demand, the price may be lowered in order to compete for market share.
According to past transactions and market insights, the price of this compound may range from tens to hundreds of yuan per gram. In special customized scenarios with small batches and extremely high purity requirements, the price may be hundreds of yuan per gram or even higher; when the batch is large and the purity requirements are relatively ordinary, the price per gram may be reduced to tens of yuan. However, this is only a rough range. It is difficult to determine the current market price accurately. Due to the rapidly changing market, the pricing strategies of various suppliers are also different. If you want to know the exact price, you should consult the suppliers in detail or carefully observe the real-time market conditions on the chemical product trading platform.