2-HYDROXY-3-IODO-5-NITROPYRIDINE

2-Hydroxy-3-iodine-5-nitropyridine is an organic compound. It has a wide range of uses and has its presence in many fields.
First, in the field of medicinal chemistry, this compound is often used as an important intermediate. Pharmaceutical developers often use it as a starting material through a series of delicate chemical reactions to carefully construct molecular structures with specific pharmacological activities. Because of its special chemical functional groups, such as hydroxyl, iodine atoms and nitro groups, it can endow the synthesized drug molecules with unique properties, or enhance their ability to bind to biological targets, or optimize their pharmacokinetic properties, helping to create new drugs to cure various diseases.
Second, in the field of materials science, 2-hydroxy-3-iodine-5-nitropyridine also has extraordinary performance. Due to the characteristics of its chemical structure, it can participate in the synthesis process of materials, endowing materials with special electrical, optical or thermal properties. For example, in the preparation of some organic optoelectronic materials, the introduction of this compound may regulate the electronic transport properties of materials, improve the photosensitivity of materials to specific wavelengths of light, and thus be applied to cutting-edge materials such as organic Light Emitting Diodes and solar cells.
Third, in the field of organic synthetic chemistry, it is a crucial building block. Chemists can take advantage of the activity of their functional groups and combine them with other organic molecules through cleverly designed reaction routes to build complex and novel organic compounds. This process is like building a delicate building block, each step of the reaction needs to be precisely controlled, and 2-hydroxy-3-iodine-5-nitropyridine plays an indispensable role in this construction process, injecting a steady stream of vitality into the development of organic synthetic chemistry.

2-Hydroxy-3-iodine-5-nitropyridine is a kind of organic compound. Its physical properties are very important and are related to many chemical application fields.
Looking at its appearance, under normal temperature and pressure, this substance is often in a solid state. However, its specific form is either crystalline or powdery, which varies depending on the preparation method and conditions.
When it comes to melting point, 2-hydroxy-3-iodine-5-nitropyridine has a specific value. Melting point, the temperature at which a substance changes from a solid state to a liquid state. The melting point of this compound is crucial for its purification, identification, and behavior under specific reaction conditions. By accurately measuring the melting point, chemists can determine the purity of the substance. If impurities are mixed in, the melting point may decrease and the melting range becomes wider.
Solubility is also one of its important physical properties. In common organic solvents, their solubility varies. In some polar organic solvents, such as ethanol and acetone, there may be a certain solubility due to the interaction between the polarity of the molecule and the solvent. In non-polar solvents, such as n-hexane, the solubility may be very low, because the polar characteristics of the molecular structure are difficult to compatible with non-polar solvents. The solubility in water also needs to be considered. Due to the special polarity of water, the degree of solubility of the compound in water has a significant impact on its reaction or application in aqueous systems.
In addition, the density of 2-hydroxy-3-iodine-5-nitropyridine is also a physical parameter. Density reflects the mass of a substance per unit volume. Although it may not be as important as melting point and solubility in general chemical operations, density data are also indispensable when it comes to accurate measurement or simulation of specific physical processes.
In summary, the physical properties of 2-hydroxy-3-iodine-5-nitropyridine, such as appearance, melting point, solubility, and density, play an important role in chemical research and practical applications. With a deep understanding of these properties, chemists can better control the chemical reactions and processes related to them.

The chemical synthesis method of 2-hydroxy-3-iodine-5-nitropyridine is as follows.
Pyridine is first taken as the initial raw material, because its structure contains nitrogen heterocycles and its properties are active, which can be used as the reaction infrastructure. Sulfuric acid and nitric acid are mixed to form a mixed acid, and slowly drop into the pyridine solution at a specific temperature range, such as 0-10 ° C. Under the action of sulfuric acid, nitroyl positive ions are formed, which are electrophilic reagents and attack the pyridine ring. The electron cloud density distribution on the pyridine ring is uneven, and the electron cloud density of the adjacent and para-sites of nitrogen atoms is relatively low, and the meta-site is high. Therefore, nitroyl positive ions preferentially attack the meta-site to generate 3-nitropyridine. This step requires precise temperature control to prevent the occurrence of side reactions of polynitrogenation.
After obtaining 3-nitropyridine, dissolve it in a suitable organic solvent, such as dichloromethane, cool it to -10-0 ° C, and slowly add iodine and an appropriate oxidant, such as hydrogen peroxide and sulfuric acid mixture. Iodine generates iodine positive ions under the action of oxidizing agents. As an electrophilic agent, because the nitro group in 3-nitropyridine is the meta-locator group, the iodine positive ion attacks the nitro meta-locator, that is, the 5-position, to obtain 3-iodine-5-nitropyridine. In this step, pay attention to the amount of oxidant and the drip rate to avoid excessive oxidation.
Finally, 3-iodine-5-nitropyridine is mixed with a strong base, such as sodium hydroxide aqueous solution, and heated to reflux. The 2-position on the pyridine ring is affected by the electron-absorbing effect of nitro and iodine, and the electron cloud density decreases. Hydroxy negative ions are easy to attack this position, and nucleophilic substitution reactions occur, replacing iodine atoms to generate 2-hydroxy-3-iodine-5-nitropyridine. After the reaction, the pure product can be obtained through post-processing steps such as cooling, acidification, extraction, and recrystallization.
Each step of the reaction requires strict control of the reaction conditions, including temperature, reagent dosage, reaction time, etc., and the post-processing process is also related to the purity and yield of the product. All aspects cannot be ignored, so that 2-hydroxy-3-iodine-5-nitropyridine can be efficiently synthesized.

2-Hydroxy-3-iodine-5-nitropyridine is an organic compound. When storing it, many things must be paid attention to.
Bear the brunt, the temperature and humidity of the storage environment are very important. It should be placed in a cool, dry place, away from high temperature and humidity. High temperature can easily accelerate its chemical reaction, or cause the risk of decomposition and deterioration; moisture may make it absorb moisture, affecting its purity and stability.
Furthermore, light should not be ignored. This compound may be sensitive to light, so it should be stored in a dark place, especially in a brown bottle, which can reduce the effect of light on its structure and properties.
In addition, the storage place should be kept away from fire sources, heat sources and oxidants. Due to its specific chemical properties, it may be exposed to fire, heat or oxidants, or react violently, such as combustion, explosion, etc., endangering safety.
Also, it needs to be placed separately from other chemicals to avoid mixed storage. Different chemicals may sometimes react chemically, causing them to fail or produce dangerous products.
And the storage area should be well ventilated. If the ventilation is poor, the volatile gas will accumulate, or the concentration will be too high, which will not only endanger the environment but also increase safety hazards.
Furthermore, during storage, it should be regularly checked whether its packaging is in good condition. If the packaging is damaged, it is easy to contact with the external environment and accelerate deterioration. At the same time, record the storage time, conditions and other information for traceability and management.
In conclusion, proper storage of 2-hydroxy-3-iodine-5-nitropyridine is of great significance to maintaining its quality and safety. All factors need to be carefully considered and must not be taken lightly.

What I am asking you is about the market price range of "2-hydroxy-3-iodine-5-nitropyridine". However, the price of this chemical is difficult to determine with certainty, and it is subject to many factors.
First, the cost of production. The price of raw materials, the difficulty of production processes, and the amount of energy consumption are all related to costs. If raw materials are scarce and expensive, or the production process is complicated and special equipment and technology are required, the cost will be high, and the price will rise accordingly.
Second, the supply and demand of the market. If there are many people who want it, but there are few people who supply it, the price will rise; on the contrary, if the supply exceeds the demand, the price may drop. And different industries have different needs, such as pharmaceutical synthesis, chemical research, etc. Differences in their demand also affect the price.
Third, the grade of quality. High purity, high quality, the price is often higher than ordinary. Merchants may set different prices according to different qualities.
Fourth, regional factors. Different regions, due to differences in transportation costs, local economic level, and market competition, the price is also different. In places with developed economy and convenient transportation, or due to fierce competition, the price is slightly lower; in remote places with inconvenient transportation, the price may be slightly higher.
According to past market conditions and similar chemical prices, the price of "2-Hydroxy-3-Iodine-5-Nitropyridine" may range from tens to hundreds of yuan per gram. However, this is only a rough estimate, and the actual price should be determined according to real-time market conditions, specific trading conditions and negotiation between buyers and sellers. For accurate prices, consult chemical raw material suppliers, chemical trading platforms, or relevant industry personnel to obtain accurate figures.