2-Hydroxy-3-cyanopyridine

2-Hydroxy-3-cyanopyridine has a wide range of uses. It is used in the field of medicine and is a key synthesis intermediate. It covers the preparation of many drugs, relying on this as the basis, through delicate chemical reactions, to obtain drugs. For example, some antibacterial drugs with unique curative effects, 2-hydroxy-3-cyanopyridine plays an indispensable role in its synthesis step, helping it build a specific chemical structure to become an effective antibacterial active ingredient.
In the field of pesticides, it also has important applications. It can be used as a starting material for the creation of new pesticides, and chemically modified and transformed to generate compounds with high insecticidal, bactericidal or herbicidal properties. This kind of pesticide based on 2-hydroxy-3-cyanopyridine can precisely act on the specific physiological links of pests, improve the control effect, and have a small impact on the environment, which is in line with the current development needs of green agriculture.
Furthermore, in the field of materials science, it has also emerged. It can participate in the preparation of materials with special functions, such as polymer materials with specific optical and electrical properties. The unique chemical properties of cyanide and hydroxyl groups can endow materials with different reactivity and structural characteristics. After rational design and polymerization, advanced materials that meet the needs of specific application scenarios can be prepared, which can be used in electronic devices, optical instruments and many other aspects.
Overall, 2-hydroxy-3-cyanopyridine has important uses in many fields such as medicine, pesticides and materials science due to its unique chemical structure, and plays an important role in promoting scientific and technological progress in various fields.

2-Hydroxy-3-cyanopyridine, this is a kind of organic compound. Its physical properties are as follows:
Looking at its appearance, it usually takes the shape of white to pale yellow crystalline powder under normal conditions. It is delicate and uniform in texture. It flickers under light or in the presence of a faint light, just like the tiny stars scattered among it.
When it comes to the melting point, it is about 165-168 ° C. When the temperature gradually rises, the substance begins to slowly melt from a solid state to a liquid state, just like ice and snow in the warm sun, quietly changing its form. This melting point characteristic is crucial in the process of identification and purification, and can be used for precise temperature control to achieve the purpose of separation and purification.
Its solubility also has its own characteristics. In water, it can be slightly dissolved, just like raindrops falling into a shallow pool, partially integrated, and partially retained. In organic solvents, such as methanol, ethanol, and dichloromethane, the solubility is quite good, just like fish get water, easily dispersed in it. This difference in solubility provides a variety of options for its application in different chemical reactions and industrial processes.
Furthermore, the stability of this substance is still good. In a dry and ventilated environment at room temperature and pressure, it can be stored for a long time and is not prone to qualitative changes. However, in case of extreme conditions such as high temperature and strong acid and alkali, its chemical structure may be affected and corresponding reactions will occur.
The physical properties of 2-hydroxy-3-cyanopyridine are of great significance in the fields of organic synthesis and drug development. Due to its unique appearance, melting point, and solubility, it can meet many specific process requirements, laying the foundation for the development of related industries.

The synthesis method of 2-hydroxy-3-cyanopyridine is not directly described in the ancient book "Tiangong Kaiwu", but it can be deduced according to the ancient ideas and the development of chemical industry in later generations.
First, it can be started from 2-hydroxy pyridine. The cyano group is introduced before the third position of the pyridine ring, which can be replaced by nucleophilic substitution. The nitrogen atom on the pyridine ring has electron-absorbing properties, which makes the electron cloud density on the ring uneven, and the third position is relatively active. A suitable cyanide reagent, such as potassium cyanide or sodium cyanide, can be selected. Under appropriate reaction conditions, such as in polar solvents, under the catalysis of bases, the cyanyl group replaces the suitable leaving group at the 3 position, such as a halogen atom (if the halogen atom is introduced before the 3 position). After this step, 2-hydroxy-3-cyanopyridine can be obtained.
Second, 3-cyanopyridine is used as the starting material. Because the cyanyl group on the pyridine ring is an electron-withdrawing group, the electron cloud density of the pyridine ring can be reduced, making it relatively difficult to introduce hydroxyl groups. However, by means of oxidation reaction, the nitrogen atom of 3-cyanopyridine can be oxidized first to enhance the electrophilicity of the pyridine ring, and then water or other hydroxyl-containing reagents can be used as the hydroxyl source. Under acidic or basic catalytic conditions, the hydroxyl group can be substituted for the hydrogen atom at the 2 position of the pyridine ring to obtain 2-hydroxy-3-cyanopyridine.
Third, the pyridine ring can also be constructed from a simple organic compound through multi-step reaction and the desired functional group can be introduced. For example, small molecule compounds containing nitrogen, carbon and oxygen, such as malononitrile, ethyl acetoacetate, etc., are first constructed by a series of reactions such as condensation and cyclization. Then, at a suitable stage, through oxidation, substitution and other reactions, hydroxyl groups are introduced into the second position of the pyridine ring and cyanyl groups are introduced into the third position, so as to obtain 2-hydroxy-3-cyanopyridine. Although these methods are not perfect, the synthesis path of this compound may be obtained by following this idea.

2-Hydroxy-3-cyanopyridine is an important organic compound. During storage and transportation, many matters need to be paid special attention.
First of all, storage, this compound should be stored in a cool, dry and well-ventilated place. Because of its certain chemical activity, if it exists in a high temperature environment, it may cause its chemical properties to change, and even cause reactions such as decomposition. Humidity also has a great impact. Humid environment or cause it to absorb moisture, which affects quality. Be sure to keep away from fires and heat sources, because it is exposed to open flames, hot topics or the risk of combustion and explosion. At the same time, it should be stored separately from oxidants, acids, bases, etc., because these substances may chemically react with them, reducing the purity of the product, or even causing danger.
As for transportation, it is necessary to ensure that the packaging is complete and sealed before transportation. Packaging materials need to be able to effectively protect the product and avoid it from external factors. During transportation, it is necessary to ensure that the container does not leak, collapse, fall or damage. Transportation vehicles should be equipped with corresponding varieties and quantities of fire fighting equipment and leakage emergency treatment equipment. When driving, it is necessary to follow the prescribed route and do not stop in residential areas and densely populated areas. When loading and unloading, the operator should wear appropriate protective equipment and handle it lightly to prevent damage to the packaging and containers.
In conclusion, 2-hydroxy-3-cyanopyridine needs to be carefully treated in terms of environment, packaging, and protection during storage and transportation to ensure its quality and transportation safety.

2-Hydroxy-3-cyanopyridine is also a chemical substance. To know its market price trend, look at all the reasons.
In the past, it needs to change in various industries. If the pharmaceutical industry develops new drugs and uses this material, it needs to increase the price or increase; on the contrary, it needs to decrease the price or reduce it. For the chemical industry, if it is used as a raw material to make other substances, its industry will seek more, and the price will also rise; if the industry is tired, it will seek less, and the price will fall.
And its production is also related to the price trend. If the place of origin is wide and the production is abundant, the price will always be stable or drop; if the place of origin is narrow, the production will be limited due to various reasons, and the price will easily rise. If the weather is not good or the conditions of the land change, which hinders the production, the price will be moved by it.
Furthermore, the competition in the market is also heavy. When the merchants compete for sales, they must bid for the market at a price, and the price will be reduced or lowered; they will be provided by independent merchants, or the price will be increased by controlling the quantity.
It is difficult to know the exact trend of the price. The city today is fickle, although it is based on the traces of ancient times, it is only approximate. It is necessary to observe the market situation and research situation frequently to understand the price trend of 2-hydroxy-3-cyanopyridine.