2 Hydrazinopyridine
pyridine pyrrole pyrazine piperidine piperazine

2-hydrazinopyridine

    Specifications

    HS Code

    930564

    Chemical Formula C5H7N3
    Molar Mass 109.13 g/mol
    Appearance Solid
    Odor Typical of pyridine - like compounds
    Solubility In Water Moderate solubility
    Melting Point Varies depending on isomer
    Boiling Point Varies depending on isomer
    Density Data depends on isomer
    Pka Characteristic acid - base property value specific to the structure
    Reactivity Can react with electrophiles, nucleophiles

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    General Information
    Where to Buy 2-hydrazinopyridine in China?
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    Frequently Asked Questions

    As a leading 2-hydrazinopyridine supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the main uses of 2-hydrazinopyridine?
    The main use of 2-% energy is to assist in the control of biochemical reactions, and also to improve the performance of certain physiological processes.
    In general biochemical processes, 2-% energy can be used as an important medium. It plays an indispensable role in the process of cellular generation. For example, in some enzymatic reactions, 2-% energy can reduce the activity of the whole enzyme, so that the biochemical reaction can be promoted effectively, just like a boat traveling in water, with the help of a sail.
    Furthermore, in terms of physiological performance, its spiritual performance has a certain shadow. Or the synthesis of the divine, so that the divine can be realized quickly and quickly, such as standing in the way, through the resistance. This is essential for the normal function of the spiritual system, such as perception, intelligence, etc.
    In addition, 2-% oil also plays an important role in the generation of fat. It can help the generation of fat, avoid the frequent accumulation of fat, such as the dredger of the river, so that the flow of fat replacement can be passed through without silting.
    Therefore, 2-% oil is essential for the control of biochemical reactions and the maintenance of physiological energy. It has an important role in the production of life.
    What are the physical properties of 2-hydrazinopyridine?
    2-% nitrile pyridine is an organic compound with unique physical properties. This substance is mostly colorless to light yellow liquid under normal conditions, and can also be a crystalline solid under specific conditions. Its melting point is about -21 ° C and its boiling point is between 201-202 ° C. This melting and boiling point characteristic makes it relatively stable in many chemical reaction conditions, and can be used as an ideal reactant or reaction medium under specific reaction environments.
    2-% nitrile pyridine has a density of about 1.08 g/cm ³. Compared with common organic solvents such as water and ethanol, the density difference is significant. It is widely used in mixture separation and phase transfer catalysis. Due to its density characteristics, preliminary separation from other substances can be achieved by means of density difference, thereby simplifying the processing process of complex mixtures.
    The solubility of this substance is also worthy of attention. It is soluble in common organic solvents such as methanol, ethanol, ether, etc., but difficult to dissolve in water. This solubility characteristic plays a key role in the field of organic synthesis. During the synthesis process, a suitable organic solvent system containing 2-% nitrile pyridine can be selected according to the reaction requirements to promote the smooth progress of the reaction. For example, in some nucleophilic substitution reactions, selecting a suitable organic solvent to dissolve 2-% nitrile pyridine can effectively increase the contact probability of the reactants, thereby accelerating the reaction rate.
    In addition, 2-% nitrile pyridine is also volatile, and in poorly ventilated environments, its volatile gases may accumulate, so careful operation is required. Although its vapor pressure is not high at room temperature, it increases with the increase of temperature. Pay attention to temperature control and ventilation measures when using it to ensure the safety of the experimental or production environment and avoid safety accidents caused by high gas concentration.
    What are the chemical properties of 2-hydrazinopyridine?
    2-% nitrile pyridine, also known as 2-cyanopyridine, is an important raw material for organic synthesis. Its chemical properties are unique, with the dual characteristics of nitrile group and pyridine ring, and it shows special activity in many chemical reactions.
    The nitrile group is a strong electron-absorbing group, and the nitrogen atom of the pyridine ring also has an electron-absorbing effect. The synergy between the two makes the electron cloud of 2-% nitrile pyridine unique and active in electrophilic substitution. On its pyridine ring, due to the difference in electron cloud density distribution, the electrophilic substitution activity at different positions is different. For example, the 3-position and the 5-position are relatively active. They are often the check point for the attack of electrophilic reagents. Halogenation, nitrification, sulfonation and other reactions can occur. Various functional groups are introduced to expand its chemical derivation path.
    The nitrile group of 2-% nitrile pyridine can undergo a series of characteristic reactions. During hydrolysis, under the catalysis of acids or bases, it can be gradually converted into amides, and then carboxylic acids are formed. This property is used in organic synthesis to construct compounds containing carboxyl groups or amide groups. Nitrile groups can also react with Grignard reagents to introduce alkyl groups and other groups to grow carbon chains and And under the action of appropriate reducing agents, the nitrile group can be reduced to an amine group, providing an effective way for the preparation of nitrogen-containing organic compounds.
    The nitrogen atom of the pyridine ring makes 2-% nitrile pyridine weakly basic, which can react with acids to form salts and improve its solubility in water. This property has application value in drug synthesis and some catalytic reaction systems, and can adjust the physical and chemical properties of compounds to meet specific reaction or application requirements.
    In addition, the conjugated structure of 2-% nitrile pyridine makes it have certain optical and electrical properties. In the field of materials science, it can be used as a construction unit to synthesize materials with specific photoelectric properties. Due to its unique chemical properties, 2-% nitrile pyridine is widely used and has important research value in many fields such as medicine, pesticides, and materials.
    What are the synthesis methods of 2-hydrazinopyridine?
    There are many methods for synthesizing 2-aminopyridine, each with its own advantages and disadvantages. The following are common methods:
    1. ** Conrad-Limpach reaction **: β-aminopyridine and ethyl acetoacetate are used as raw materials, condensed under appropriate conditions, and then cyclized and dehydrated to obtain 2-aminopyridine. This reaction condition is relatively mild, and the raw materials are relatively easy to obtain. However, there are slightly more reaction steps, and the reaction conditions of each step need to be carefully controlled to improve the yield and purity. The reaction mechanism is based on the condensation and cyclization of esters. Through ingenious regulation of reaction temperature, catalyst and other factors, the molecular structure is rearranged to form a pyridine ring and an amino group is introduced.
    2. ** Hantzsch reaction **: Dihydropyridine compounds are formed by multi-step reaction with aldehyde, β-ketoate and ammonia (or ammonium salt) as raw materials, and then oxidized and dehydrogenated to 2-aminopyridine. This method has a wide range of raw materials and high reaction yield. However, the oxidative dehydrogenation step may require the use of a specific oxidant, and the post-reaction treatment is slightly complicated, so the product needs to be properly separated and purified. In this process, the condensation reaction between aldehyde and β-ketoate first occurs to form the prototype of the pyridine ring, and then ammonia participates in the reaction, introducing amino groups, and finally oxidizing dehydrogenation to form a stable pyridine structure.
    3. ** Ammonolysis of pyridine halide **: With 2-halogenated pyridine and ammonia (or organic amine) as raw materials, under appropriate catalyst and reaction conditions, the halogenated atom is replaced by an amino group to generate 2-aminopyridine. This method is simple and convenient to operate. However, the preparation of 2-halogenated pyridine may require additional steps, and the difference in the activity of halogenated pyridine also requires different reaction conditions. During the reaction, the activity of the halogen atom interacts with the nucleophilicity of ammonia to achieve the substitution of the amino group to the halogen atom, thereby achieving the synthesis of the target product.
    4. ** Transition metal catalyzed coupling reaction **: With the help of transition metal catalysts, such as palladium, copper, etc., the nitrogen-containing reagent is coupled with the pyridine derivative to generate 2-aminopyridine. This method has the advantages of high efficiency and good selectivity, and can realize the construction of complex molecules under relatively mild conditions. However, transition metal catalysts are expensive, and the reaction system is sensitive to impurities. The reaction environment needs to be strictly controlled to ensure the catalytic effect and product purity. In the reaction, transition metal catalysts activate the reactant molecules, promote the formation and cleavage of chemical bonds, and precisely realize the connection between amino groups and pyridine rings.
    What are the precautions for using 2-hydrazinopyridine?
    Fuchicarbonyl is also a common group in chemistry. When using it, many matters need to be paid attention to.
    The first one to bear the brunt is its activity. Dicarbonyl has high activity and is easy to interact with other substances in many reactions. For example, in condensation reactions, dicarbonyl compounds can form Schiff bases with amines, and precise temperature control and timing are required in this process. Excessive temperature or too long reaction time can cause side reactions to cluster and impure products.
    Furthermore, stability is also the key. The structure of dicarbonyl is sometimes unstable, and it may change in response to light, heat or specific reagents, or decomposition and rearrangement. If it is exposed to light, some dicarbonyl compounds may undergo structural changes due to photochemical reactions, which affects their properties and uses.
    Solubility should not be underestimated. Dicarbonyl compounds have different solubility in different solvents. When choosing a solvent, it must be determined according to its reaction requirements and compound characteristics. In some organic synthesis reactions, the right solvent is selected to ensure that the dicarbonyl compound is fully dispersed and the reaction proceeds smoothly. If the solvent is not selected properly, or the reactants are not fully contacted, the reaction rate slows down, and even the reaction cannot occur.
    In addition, dicarbonyl compounds may have certain toxicity and irritation. When operating, be sure to take protective measures, such as wearing gloves, goggles, and working with good ventilation. If you accidentally come into contact with the skin or inhale its volatile gas, or cause damage to the human body.
    When using dicarbonyl, consider its activity, stability, solubility and safety in detail, and operate with caution to ensure a smooth and orderly process and achieve the desired purpose.