2-furfuryl pyridine

2-% carboxypyridine is mainly used in the manufacture of medicines, pesticides and dyes. In the field of medicine, it is a key intermediate in the synthesis of various drugs. For example, in the preparation of some antibacterial drugs, 2-carboxypyridine participates in specific reaction steps, which can construct molecular structures with antibacterial activity and play an important role in the treatment of related diseases.
In terms of pesticides, it can be used as an important raw material for the synthesis of highly efficient and low-toxicity pesticides. Through a series of chemical reactions, pesticide products with good control effects against specific pests or diseases can be prepared, which can help agricultural production reduce the infestation of pests and diseases and ensure the yield and quality of crops.
In the dye industry, 2-carboxypyridine also plays an indispensable role. Based on it, a variety of dyes with bright colors and good stability can be synthesized. These dyes are widely used in textiles, printing and dyeing and other industries, making fabrics show rich, diverse and long-lasting bright colors.
As mentioned in "Tiangong Kaiwu", everything in the world has its uses. Although 2-carboxypyridine is small, it is a key thing in the fields of medicine, pesticides and dyes, and it is related to many aspects of people's livelihood. Its application in various industries is like a tenon-and-mortise fit. Without it, it is difficult to achieve it. It is an indispensable link in the industrial manufacturing chain and promotes the continuous development and progress of related industries.

2-Aminopyridine is an organic compound with unique physical properties. Looking at its properties, it is a colorless to light yellow liquid at room temperature, with a specific odor. This odor is similar to the characteristic odor of pyridine compounds. It persists in the air for a long time, or the color becomes darker due to oxidation.
When it comes to the melting point, the melting point of 2-aminopyridine is about 58-62 ° C. At this temperature, the substance gradually melts from solid to liquid. The boiling point is around 204-206 ° C. When it reaches this temperature, the liquid is violently vaporized and converted to a gaseous state. The phase change in a specific temperature range has a great impact on its storage, transportation and use.
In terms of solubility, 2-aminopyridine is soluble in water, and it is also easily soluble in most organic solvents such as ethanol and ether. This property is due to its molecular structure. The presence of amino and pyridine rings in the molecule makes the molecule have a certain polarity, so it can form intermolecular forces with water and polar organic solvents, and then dissolve each other. The property of being soluble in water makes it play a role in chemical reactions or applications of some aqueous systems; the property of being soluble in organic solvents makes it widely used in organic synthesis, extraction and separation.
The density is about 1.129 g/cm ³, which is slightly heavier than water. This density feature needs to be taken into account when it comes to liquid-liquid separation, mixing, etc. Because of the difference between density and water, it determines the location and distribution in the mixed system.
In addition, 2-aminopyridine has sublimation. Although it is relatively weak, it can directly change from solid state to gaseous state under certain temperature and pressure conditions. This property may be used in the purification and analysis of substances. Its vapor pressure has a corresponding value at a specific temperature, and the vapor pressure reflects the degree of difficulty of volatilization of the substance. The relevant data of 2-aminopyridine vapor pressure is of great significance for the evaluation of its volatility under different temperature environments.

2-% aminopyridine, weakly basic, its nitrogen atom has unshared electron pairs, which can form salts with acids. It can be ionized in a small amount in water, showing a weakly basic state.
It is also nucleophilic, and the unshared electron pairs of its nitrogen atom can attack the electrophilic reagent and form new bonds. If it reacts with halogenated hydrocarbons, the nitrogen atom nucleophilic replaces the halogen atom to obtain a nitrogen-containing derivative.
has a conjugated system, and the pyridine ring has a conjugated π bond, which gives it a certain stability and a special electron cloud distribution. Due to the conjugation effect, the electron cloud density on the ring is uneven, resulting in its electrophilic substitution reaction activity is different from that of benzene. The reaction mostly occurs at the β-position (3-position). Due to the relatively high electron cloud density at this position, electrophilic reagents are easy to attack.
And can participate in coordination reactions. Nitrogen atoms can provide electron pairs to coordinate with metal ions to form metal complexes. This property is widely used in catalysis, materials science and other fields, and can regulate the activity and properties of metal ions.
In organic synthesis, 2-aminopyridine is an important raw material and intermediate. After many reactions, it can produce a variety of nitrogen-containing compounds, such as drugs, dyes, pesticides, etc., which play an important role in chemical, pharmaceutical and other industries.

The preparation method of diaminopyridine, although the "Tiangong Kaiwu" does not specify the specific method of this drug, it can be deduced from the relevant technological ideas.
Ancient pharmaceuticals often rely on material properties and existing skills. In the preparation of diaminopyridine, it can be obtained by chemical changes starting from natural substances. Looking at "Tiangong Kaiwu", the method of transformation of many substances described in it may be used for reference.
For example, metal smelting, calcination by fire, and chemical reactions make metals in ores precipitate. The preparation of diaminopyridine may be natural nitrogen-containing and carbon-containing materials. There are many nitrogen-containing plants and ores in nature, and such raw materials can be taken first. For example, some nitrogen-containing ores are ground into fine powder. This is the initial treatment, which increases the contact area with the reactant and is conducive to subsequent changes.
Then, the method of combining water and fire is used. According to "Tiangong Kaiwu", many reactions require precise temperature control. In the preparation of diaminopyridine, a stove can be set up to heat the material with suitable fuel, so that the material can react at a specific temperature. Or some fluxes or catalysts can be added to speed up the reaction process. This is similar to "Tiangong Kaiwu" when smelting metals, adding fluxes such as borax to promote the separation of metals and impurities.
During the reaction process, closely observe the changes of the material, such as color, odor, and morphology. If the color gradually changes, it may indicate the direction and degree of reaction. Adjust the temperature and reaction time in a timely manner. After the reaction is completed, the product is obtained or mixed with impurities. At this time, it can be purified by filtration, distillation and other methods. "Tiangong Kaiwu" records the purification process such as winemaking, and the liquor of winemaking is also mixed with impurities, and its purity is improved by distillation. To prepare diaminopyridine, or by distillation, according to its boiling point, separate the pure product to obtain a purer diaminopyridine. Although the ancient method is different from today's fine chemical process, its dependence on matter, change, and purification ideas can be used as a guide for exploring diaminopyridine production methods.

When using 2-aminopyridine, there are many things that cannot be ignored.
The first thing to know is its properties. 2-aminopyridine is alkaline and has certain chemical activity. When using it, be careful to avoid mixing with acids and other substances that can react violently. If you accidentally encounter it, you may cause a violent chemical reaction, which may cause material deterioration in the light case, or the risk of ignition and explosion in the heavy case, endangering the safety of people and property.
The second time, be careful to protect it. This substance may be irritating and may cause discomfort in contact with the skin, eyes and eyes. Therefore, when operating, use appropriate protective equipment, such as gloves, goggles, etc. If the skin touches it, rinse quickly with plenty of water, followed by soap; if it enters the eyes, rinse thoroughly with flowing water immediately and seek medical treatment immediately.
Furthermore, in the storage environment, choose a cool, dry and well-ventilated place. Keep away from fire and heat sources to prevent decomposition by heat or cause other hazards. And it should be stored in separate stores with oxidants and acids, and must not be mixed to avoid disasters due to unexpected reactions.
Also, the place of use should be well ventilated. Because of its volatile gas or certain hazards, good ventilation can reduce its concentration in the air and reduce the risk of inhalation.
And the operation process should be strictly followed. Weighing, taking and other steps must be accurate and not hasty. After use, properly dispose of the remaining items and do not discard them at will to avoid polluting the environment and preventing subsequent accidents.
In short, when using 2-aminopyridine, you must pay attention everywhere, be cautious in everything, and the security will be safe and the operation will be smooth.