2-Formylpyridine-5-Boronic Acid Pinacol Ester

2-formylpyridine-5-boronic acid pinacol ester, which has a wide range of uses. In the field of organic synthesis, it is often used as a key intermediate to participate in the construction of complex organic molecular structures.
In the field of medicinal chemistry, new drug molecules with unique physiological activities can be created by coupling reactions with other compounds containing specific functional groups. The structure of the geopyridine ring and borate esters can endow the synthesized drugs with specific physical and chemical properties and biological activities, helping them to better meet the needs of drug targets.
It also plays an important role in materials science. It can be introduced into the structure of polymer materials through specific chemical reactions to improve the optical and electrical properties of the materials. For example, in the preparation of organic optoelectronic materials, through rational design and synthesis, the compound can be used to construct efficient charge transport channels and improve the photoelectric conversion efficiency of the material, so as to be applied to the manufacture of organic Light Emitting Diodes, solar cells and other devices.
In addition, in the field of chemical biology, it can be used as a precursor to probe molecules. By selectively reacting with specific molecules in living organisms, it can realize the labeling and detection of biomolecules, providing a powerful tool for the study of biochemical processes in living organisms. In conclusion, 2-formylpyridine-5-boronic acid pinacol ester plays an indispensable role in many scientific research and industrial production fields due to its unique structure and reactivity, and has made great contributions to the development of various fields.

2-formylpyridine-5-boronic acid pinacol ester is an important organoboron compound commonly used in the field of organic synthesis. This substance has unique physical properties, which has a great impact on its application in organic synthesis reactions.
Looking at its properties, under normal temperature and pressure, 2-formylpyridine-5-boronic acid pinacol ester is mostly white to light yellow crystalline powder, with pure appearance and fine and uniform texture. This morphology is conducive to weighing and accurate use. In the experimental operation of organic synthesis, it can effectively ensure the accurate dosage of reactants, thereby improving the reproducibility of the reaction and the reliability of the experimental results.
When it comes to melting point, the melting point range of this compound is usually in a certain range, about [specific melting point value] ℃. Melting point is a key indicator for identification and purity determination. If the purity of the compound is high, the melting point is sharp and the melting range is short; conversely, if it contains impurities, the melting point will be reduced and the melting range will become longer. Therefore, melting point determination is an important means to evaluate the purity of 2-formylpyridine-5-boronic acid pinacol ester.
In terms of solubility, 2-formylpyridine-5-boronic acid pinacol ester exhibits good solubility in common organic solvents such as dichloromethane, chloroform, tetrahydrofuran and toluene. This property allows it to be easily dispersed in the reaction system, fully contacted with other reactants and reacted, creating favorable conditions for the smooth progress of organic synthesis reactions. However, in water, its solubility is poor, which is mainly due to the dominant position of hydrophobic groups in the molecular structure of the compound, and the weak interaction with water molecules.
In terms of stability, 2-formylpyridine-5-boronic acid pinacol ester is relatively stable under normal conditions, but it is more sensitive to humidity and air. In high humidity environments, borate ester groups are prone to hydrolysis reactions, resulting in structural changes that affect their reactivity and application effects; exposure to air may also deteriorate due to factors such as oxidation. Therefore, when storing, it is necessary to keep it sealed in a dry, cool and well-ventilated place. It is usually recommended to operate and store it in an inert gas protective atmosphere to ensure its stability and quality.

The synthesis method of 2-formylpyridine-5-boronic acid pinacol ester is an important topic in the field of organic synthesis. Its synthesis often follows the following route.
First, with 2-methylpyridine as the starting material, the methyl group can be converted into aldehyde group through oxidation reaction to generate 2-formylpyridine. In this oxidation step, common oxidants such as chromic acid, potassium permanganate, etc., however, the reaction conditions need to be carefully controlled due to strong oxidants or excessive oxidation of aldehyde groups.
Subsequently, 2-formylpyridine reacts with pinacol borane in the presence of a suitable catalyst. Commonly used catalysts are transition metal catalysts, such as palladium catalysts, which can effectively promote the occurrence of borylation reactions. During the reaction, the choice of solvent is also critical. Commonly used organic solvents such as toluene and dichloromethane need to be selected according to the specific requirements of the reaction. And the reaction temperature and time also need to be carefully controlled. Usually, the reaction is carried out under appropriate heating conditions, and it takes several hours to ten hours to achieve the ideal yield.
Or, it can be started from 5-halo-2-formylpyridine. 5-Halo-2-formylpyridine and diphenacol borate under palladium catalysis and alkali action, through metal-catalyzed coupling reaction, boron groups can be introduced to form the target product 2-formylpyridine-5-boronic acid pinacol ester. The type and amount of bases, the activity and amount of catalysts have a great impact on the reaction process and yield.
In the synthesis process, the separation and purification of the product are also important links. Common methods include column chromatography, recrystallization, etc. Column chromatography can achieve separation according to the polarity difference between the product and the impurity; recrystallization can achieve the purpose of purification by the difference in solubility of the product and the impurity in different solvents, so that high purity 2-formylpyridine-5-boronic acid pinacol ester can be obtained.

2-formylpyridine-5-boronic acid pinacol ester is a commonly used reagent in organic synthesis. When storing, many points should be paid attention to.
First, temperature control is extremely critical. This compound is quite sensitive to temperature, and high temperature is easy to cause its decomposition and deterioration. Therefore, it should be stored in a low temperature environment, generally 2-8 ° C, which is commonly found in refrigerators. In this way, it can slow down the thermal movement of molecules, reduce the chemical reaction rate, and ensure its chemical stability.
Second, moisture-proof measures are indispensable. Borate esters are easily hydrolyzed in contact with water. Once hydrolyzed, their structure and activity are affected, resulting in a significant reduction in their use. The storage container must be well sealed. A desiccant, such as silica gel, can be placed in the container to absorb the water vapor that may penetrate and maintain a dry environment.
Third, avoid light. Light can lead to luminescent chemical reactions, promoting the decomposition of 2-formylpyridine-5-boronic acid pinacol ester or other side reactions. It should be stored in a brown bottle or a container wrapped in black packaging material to block light and reduce the chance of photochemical reactions.
Fourth, the storage environment should be well ventilated. If the air in the storage space is not circulating, harmful gases or volatile vapors accumulate, or react with compounds. Good ventilation can disperse these substances in time and create a safe storage environment.
Finally, store separately from other chemicals, especially oxidizing, reducing, or acid-alkaline substances. Due to their active chemical properties, contact with these substances or cause uncontrollable chemical reactions, resulting in dangerous conditions.

I look at this question and ask about the market price of 2-formylpyridine-5-boronic acid pinacol ester. However, the market price often varies due to factors such as time, place, quality, and supply and demand, so it is difficult to say directly.
When Tiangong Kaiwu was written in the past, although it was not involved in this product, it is the same. The price of materials varies from place to place due to distance and dispersal. Where the place of origin is close and the goods are gathered, the price may be slightly flat; where the goods are thin in the distance, the price may be high.
Today, 2-formylpyridine-5-boronic acid pinacol ester, if the market of chemical raw materials is scattered, the scale is large and the supply is sufficient, the price may become stable and flat. However, in case of scarcity of raw materials, or production reduction due to process changes, the price will rise.
To know the exact price, you need to consult a chemical material merchant, or visit a chemical trading platform. Prices are often updated from time to time in various places to obtain the current near-real number. Or refer to the records of past transactions to see the trend of its price for planning.