2 Fluoropyridine 4 Carbonitrile
pyridine pyrrole pyrazine piperidine piperazine

2-fluoropyridine-4-carbonitrile

    Specifications

    HS Code

    452565

    Name 2-fluoropyridine-4-carbonitrile
    Molecular Formula C6H3FN2
    Molecular Weight 122.099 g/mol
    Cas Number 138389-28-7
    Appearance Solid (Typical)
    Boiling Point Approx. 200 - 210 °C (Estimated)
    Melting Point 46 - 49 °C
    Density 1.26 g/cm³ (Estimated)
    Solubility In Water Low solubility
    Pka Approx. - 2.9 (Estimated for pyridinium ion)
    Flash Point 84.5 °C (Estimated)

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    General Information
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    Frequently Asked Questions

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    What are the main uses of 2-fluoropyridine-4-carbonitrile?
    2-Fluoropyridine-4-formonitrile is also an organic compound. It has a wide range of uses and is often a key intermediate in the synthesis of many drugs in the field of medicinal chemistry. Due to the unique properties of fluorine-containing groups, which can change the physical, chemical and biological activities of compounds, the drugs synthesized by this method may have higher activity, better bioavailability and selectivity.
    In the field of pesticide creation, 2-fluoropyridine-4-formonitrile is also indispensable. The pesticides prepared by it may have the ability to effectively control specific pests and diseases, and due to their structural characteristics or environmental friendliness, the residues are small and the ecological impact is small.
    Furthermore, in the field of materials science, this compound may be a raw material for the synthesis of special functional materials. After clever design and reaction, materials with specific optical, electrical or other properties can be prepared for use in electronic devices, optical instruments, etc.
    From this perspective, 2-fluoropyridine-4-formonitrile plays an important role in the fields of medicine, pesticides and materials science, and is an important substance for promoting the development of related industries.
    What are the physical properties of 2-fluoropyridine-4-carbonitrile?
    2-Fluoropyridine-4-formonitrile, the physical properties of this substance are particularly important, and it is relevant to its many applications.
    First of all, its properties are mostly white to off-white solids under normal conditions. Looking at its color and shape, this feature is convenient for preliminary identification and distinction.
    times and melting point, about a specific temperature range, this value has a great influence on its phase transition and processing conditions. Accurately grasp the melting point, when heating, melting and other operations, it can be effectively regulated to ensure that its physical state meets the needs.
    Furthermore, its solubility also has characteristics. In common organic solvents such as ethanol and acetone, it has a certain solubility. This property is of great significance in chemical synthesis, separation and purification steps. With the right solvent, the substance can be dissolved, reacted, or separated from the mixture.
    In terms of density, although the value seems ordinary, it actually defines the relationship between the mass and volume of the substance. When storing, transporting, and measuring, density considerations are indispensable, and are related to the accuracy and safety of operation.
    In addition, the stability of 2-fluoropyridine-4-formonitrile is also a category of physical properties. Under normal environmental conditions, its properties are relatively stable, and may change in case of high temperature, strong light, or specific chemical substances. Only by clarifying this stability can the storage environment and usage scenarios be reasonably selected to avoid deterioration or failure due to external factors.
    These various physical properties are interrelated and have significant guiding value for the preparation, application and storage of 2-fluoropyridine-4-formonitrile in chemical research, industrial production and related fields.
    What are 2-fluoropyridine-4-carbonitrile synthesis methods?
    The synthesis of 2-fluoropyridine-4-formonitrile is an important topic in organic synthetic chemistry. Its synthesis path can be achieved by multiple methods.
    First, pyridine is used as the starting material, fluorine atoms are introduced through a halogenation reaction, and then cyanyl groups are introduced at a suitable check point. For example, pyridine is first halogenated under specific conditions, and a suitable halogenation reagent, such as a fluorohalogenating agent, is used to replace specific positions on the pyridine ring with fluorine to form fluoropyridine derivatives. Subsequently, a cyano group is introduced by a nucleophilic substitution reaction. 2-Fluoropyridine-4-formonitrile is obtained by reacting cyanide reagents with fluoropyridine derivatives, and carefully controlling the reaction conditions, such as temperature, solvent, catalyst, etc., to achieve the substitution of cyanyl groups to specific positions.
    Second, it can be synthesized by constructing a pyridine ring. Select suitable organic small molecules, such as fluorine-containing and cyanide-containing small molecule compounds, to construct a pyridine ring through cyclization. With a compound with a specific functional group as the starting material, under suitable catalyst and reaction conditions, the intramolecular cyclization is promoted through multi-step reaction to form a pyridine ring structure, and the fluorine atom and cyanyl group are precisely positioned at the 2nd and 4th positions of the pyridine ring to obtain the target product.
    Furthermore, the catalytic reaction with the help of transition metals is also an effective way. Using the unique catalytic activity of transition metal catalysts, fluorine-containing compounds and cyanide-containing compounds are coupled under their catalysis. Selecting appropriate transition metal catalysts, such as palladium and nickel, and combining with suitable ligands, optimize the reaction conditions, such as reaction temperature, time, solvent type, etc., to promote the efficient coupling of the two types of compounds to generate 2-fluoropyridine-4-formonitrile.
    There are various methods for synthesizing 2-fluoropyridine-4-formonitrile, and each method has its own advantages and disadvantages. In the actual synthesis, it is necessary to comprehensively consider many factors such as the availability of raw materials, the controllability of reaction conditions, the yield and purity of the product, and choose the most suitable method to achieve the purpose of synthesis.
    What 2-fluoropyridine-4-carbonitrile need to pay attention to when storing and transporting
    2-Fluoropyridine-4-formonitrile is a chemical commonly used in organic synthesis. When storing and transporting this chemical, pay attention to the following numbers:
    ** When storing **:
    First, choose a dry, cool and well-ventilated place. This chemical can easily cause reactions when wet, and in humid environments, it may cause quality deterioration or even safety risks. A cool environment can inhibit its chemical activity and avoid decomposition or other adverse reactions due to excessive temperature. Good ventilation can dissipate the gas that may leak in time to prevent it from accumulating and causing explosion or poisoning risk.
    Second, it should be stored separately from oxidants, acids, bases, etc. 2-Fluoropyridine-4-formonitrile is chemically active, mixed with oxidants, or has a violent oxidation reaction, causing fire or explosion; contact with acids and alkalis, or reactions such as acid and alkali neutralization, damage its quality and increase safety hazards.
    Third, the storage container must be tightly sealed. This can prevent the volatile leakage of chemicals, maintain its purity and stability, and avoid leakage from causing harm to the environment and human body. At the same time, the container material must be compatible with 2-fluoropyridine-4-formonitrile. For example, containers made of glass, specific plastics or metals should be carefully selected according to their characteristics to avoid chemical reactions between containers and chemicals.
    Fourth, in the warehouse, there should be obvious warning signs indicating the name, characteristics, hazards and emergency treatment methods of the chemical. In this way, warehouse management personnel and related operators can quickly understand its danger, operate more cautiously, and respond appropriately in case of emergency.
    ** During transportation **:
    First, the transportation vehicle must be specially inspected and maintained to ensure that the vehicle is in good condition and has no hidden dangers of leakage. The vehicle should be equipped with corresponding emergency treatment equipment and protective equipment, such as fire extinguishers, leakage emergency treatment tools, protective gloves, gas masks, etc., in case of emergency.
    Second, during transportation, be sure to ensure that the packaging is stable to prevent collision, vibration, and extrusion from causing damage to the package and leakage. 2-Fluoropyridine-4-formonitrile leaks during bumps and collisions, or due to damaged packaging, so it should be properly fixed when loading.
    Third, transportation personnel must be professionally trained to be familiar with the dangerous characteristics of 2-fluoropyridine-4-formonitrile, emergency treatment methods and transportation precautions. In this way, if there is a problem during transportation, it can be handled calmly and correctly to reduce the consequences of harm.
    Fourth, transportation route planning should also be paid attention to, avoiding sensitive areas such as densely populated areas and water source reserves. If a leak unfortunately occurs, the impact on many people and the environment can be reduced.
    What is the market outlook for 2-fluoropyridine-4-carbonitrile?
    2-Fluoropyridine-4-formonitrile is also an organic compound. In today's chemical and pharmaceutical fields, its market prospect is considerable.
    From the chemical perspective, this is an important organic synthesis intermediate. Due to the fluorine atom, the molecule is given unique physical and chemical properties, such as enhanced lipophilicity and improved metabolic stability. Therefore, when preparing high-performance materials and functionalizing organic molecules, it is often a key starting material. The chemical industry is booming, and the demand for various intermediates is increasing. With its characteristics, 2-fluoropyridine-4-formonitrile is very useful in the research and development of new materials, such as optoelectronic materials and high-performance polymer synthesis. The market demand may rise with the progress of materials science.
    As for the pharmaceutical field, fluoropyridine-containing compounds are biologically active and can be used as lead compounds in drug development. 2-Fluoropyridine-4-formonitrile may be chemically modified to develop new drugs for the treatment of specific diseases. At present, the pharmaceutical industry focuses on innovative drug research and development, and there is an urgent need for potential intermediates. This compound may emerge in the creation of anti-cancer, anti-infection and other drugs, and is valued by pharmaceutical companies. The market prospect is bright.
    However, its market development also has challenges. Optimization of the synthesis process and cost control are the key. If an efficient and green synthesis method can be developed, the production cost will be reduced, and the market competitiveness will be increased. And the market competition is fierce, enterprises need to strengthen research and development, improve product quality and production capacity, in order to win a place in the market. In conclusion, 2-fluoropyridine-4-formonitrile has great potential and broad prospects in the chemical and pharmaceutical fields despite challenges.