2-Fluoro-6-methyl-5-nitropyridine

2-% -6-methyl-5-carbonylvaleric acid, its main use in the scope of "Tiangongkai" does not directly correspond, but can be deduced from the relevant chemical industry and process principles.
In ancient times, although there is no such precise chemical name, similar organic acids containing carbonyl and methyl groups may exist in natural products. For example, in some animal and vegetable oils and fermentation products, such organic acids may be produced as intermediate products.
In chemical applications, 2-% -6-methyl-5-carbonylvaleric acid can be used as a raw material for organic synthesis. Although there was no modern concept of organic synthesis in ancient times, similar principles may exist in simple chemical processes. For example, in the fragrance making process, certain fragrance ingredients may need to participate in the reaction with similar organic acids to modulate the unique aroma. Also like the brewing process, similar organic acids may be produced during the fermentation process, which affects the flavor and quality of the wine. Although the exact structure was not known at that time, the relationship between raw materials, processes and product characteristics was known.
From a medicinal point of view, in the exploration of ancient medicine, organic acids containing such structures or existing in some medicinal plants participated in the physiological process in the body. Although the ancients did not clarify its structure and mechanism of action, through practical experience, they understood the efficacy of herbs containing such ingredients, or used to condition the body and treat certain diseases.
Furthermore, in the printing and dyeing process, 2% -6-methyl-5-carbonylvaleric acid can be used as a mordant or dye intermediate. Ancient printing and dyeing craftsmen knew that certain natural substances could help dyes adhere better to fabrics. Such organic acids may have similar effects, improving the printing and dyeing effect and making the color more vivid and lasting.

To prepare 2-hydroxy-6-methyl-5-aldehyde pyridine, there are three methods.
First, 2-methyl-5-aldehyde pyridine is used as the starting material and obtained by hydroxylation. In a suitable solvent, such as dichloromethane, N, N-dimethylformamide, add a strong oxidizing agent, such as potassium persulfate, potassium permanganate, at a suitable temperature, usually 0 ° C to 50 ° C, when the reaction number, after separation and purification, the target product can be obtained. This way, the raw materials are relatively easy to obtain, but the oxidation reaction selectivity is poor, there are many by-products, and the separation is complicated.
Second, start with 6-methyl-5-aldehyde pyridine-2-one. Under the atmosphere of inert gas, such as nitrogen and argon, dissolve it in suitable organic solvents, such as tetrahydrofuran and ether, add appropriate reducing agents, such as lithium aluminum hydride and sodium borohydride, control the temperature from 0 ° C to 30 ° C. When the reaction number is numbered, the carbonyl group is reduced to a hydroxyl group, and then after post-treatment, 2-hydroxyl-6-methyl-5-aldehyde pyridine can be obtained. The method has good selectivity, but the raw material of 6-methyl-5-aldehyde pyridine-2-one is rare and expensive.
Third, the pyridine ring is constructed by multi-step reaction to prepare it. First, use suitable raw materials, such as ethyl acetoacetate, formaldehyde, ammonia, etc., through condensation, cyclization and other reactions to construct a pyridine ring, and then introduce hydroxyl, methyl, aldehyde and other groups. Specifically, ethyl acetoacetate and formaldehyde are condensed under alkali catalysis, and then cyclized with ammonia to obtain pyridine derivatives. After methylation, aldehyde, hydroxylation and other series of reactions, the target product can be obtained. This route involves many steps and a long route, but the raw materials are commonly available. If the reaction conditions can be optimized, it may be a promising approach.

2-% Jing-6-methyl-5-nitropyridine, this physical property is as follows:
It is an organic compound, mostly in solid form at room temperature, and its color may be white to light yellow. In terms of melting and boiling point, the melting point is about [X] ° C, and the boiling point is about [X] ° C. This property makes it possible to achieve phase transformation by heating and other means under specific temperature conditions, which is conducive to separation and purification operations in chemical production.
In terms of solubility, it shows a certain solubility in common organic solvents such as ethanol and acetone, but it is difficult to dissolve in water. This property is of great significance in organic synthesis. It can choose a suitable solvent for reaction according to its solubility difference. At the same time, in the product separation stage, effective separation is achieved by means of different solubility.
In terms of stability, it is usually relatively stable under normal conditions. However, if it encounters a strong oxidizing agent, strong acid and strong alkali environment, a chemical reaction may occur. In view of this, during storage and use, it is necessary to avoid contact with such substances to prevent dangerous reactions. Like in a chemical storage warehouse, it must be separated from strong acids and bases and strong oxidizing agents.
In its molecular structure, the presence of nitro groups gives the compound a certain degree of oxidation, while methyl groups affect the distribution of its electron cloud, which in turn affects the chemical activity of the entire molecule. In the field of organic synthesis, it is often used as a key intermediate to participate in many reactions, such as nucleophilic substitution reactions, so as to prepare various organic materials or pharmaceutical intermediates with special functions.

2-% Jiang-6-methyl-5-carbonyl pyridine, this is an organic compound. Its chemical properties are unique and quite interesting.
Among this compound, the carbonyl group is active and can participate in many reactions. Carbonyl groups have strong polarity. Due to the difference in electronegativity of carbon and oxygen, the carbon is partially positively charged and the oxygen is partially negatively charged. This polarity characteristic makes the carbonyl group vulnerable to attack by nucleophiles, which in turn triggers nucleophilic addition reactions. For example, when catalyzed by acids or bases with alcohols, acetals or ketals can be formed; when reacted with amines, imines can be formed.
Furthermore, the pyridine ring also gives the compound unique properties. Pyridine ring is aromatic and relatively stable. However, because the electronegativity of nitrogen atom is higher than that of carbon atom, the electron cloud distribution of the pyridine ring is uneven, the electron cloud density of the adjacent and para-sites of the nitrogen atom is relatively low, and the meta-site is relatively high. This makes the substitution reaction region on the pyridine ring highly selective, and the electrophilic substitution reaction is more likely to occur in the meta-site. At the same time, the lone pair electrons on the nitrogen atom of pyridine can complex with metal ions, showing a certain coordination ability, which has potential application value in the fields of catalysis and materials science.
The existence of methyl groups, although relatively simple, has a significant impact on the physical and chemical properties of molecules. Methyl groups are the power supply groups, which can increase the electron cloud density of the atoms or groups connected to them through induction effects, affecting the reactivity and acidity and alkalinity of molecules. In addition, the steric hindrance effect of methyl groups cannot be ignored, which will affect the interaction between molecules and the spatial orientation of the reaction.
Overall, 2-% Jiang-6-methyl-5-carbonyl pyridine exhibits rich and diverse chemical properties due to the synergistic effect of various parts in its structure, and has potential applications and research values in many fields such as organic synthesis and medicinal chemistry.

I look at what you said about "2-hydroxy- 6-methyl-5-aldehyde-pyridine", which is a chemical substance. However, in the market price range, many factors such as its purity, supply and demand, and difficulty in preparation need to be observed.
If its purity is extremely high, it is difficult to prepare, and the market demand is quite large, its price must be high. On the contrary, if it is easier to prepare, the purity is ordinary, and the supply is sufficient, and the demand is not much, the price should be relatively simple.
Generally speaking, the price of chemical reagents can range from a few yuan per gram to hundreds of yuan per gram, or even more. For "2-hydroxy- 6-methyl-5-aldehyde-pyridine", if it is ordinary purity and used for general experiments, the price per gram may be in the tens of yuan. If it is high purity and used in key fields such as fine chemicals and pharmaceuticals, the price per gram may exceed 100 yuan or even higher.
However, the market situation is fickle, and the price fluctuates from time to time. To know the exact price range, please consult the chemical reagent suppliers in detail, or refer to the latest market conditions of the relevant chemical product trading platform to get an accurate number.