2-FLUORO-3-PYRIDINEBORONIC ACID

2-Fluoro-3-pyridyl boronic acid, its shape is like crystalline powder, often white to off-white appearance. This is a commonly used reagent in the field of organic synthesis, and it plays a major role in the construction of carbon-carbon bonds and carbon-heteroatomic bonds.
From the perspective of physical properties, it has a certain melting point, and shows moderate solubility in organic solvents, such as common ethanol, ether, dichloromethane, etc. However, in water, its solubility is relatively limited.
In terms of chemical properties, the boric acid contains boron-oxygen bonds and fluorine atoms, and the boron-oxygen bond activity is quite high, which can actively react with many nucleophiles. With the help of alkali, it can be coupled with halogenated hydrocarbons, olefins, etc., which is the famous Suzuki-Miyaura coupling reaction, which can efficiently build complex organic molecular structures.
Its fluorine-containing atoms give unique electronic effects and fat solubility to the molecule. Fluorine atoms have high electronegativity, which can change the electron cloud density of the pyridine ring, affecting its reactivity and selectivity. Due to the existence of fluorine atoms, this compound has also attracted much attention in the field of bioactive molecules and drug development, and may be able to contribute to the creation of new drugs. However, when participating in chemical reactions, it is necessary to pay attention to the precise regulation of reaction conditions. Factors such as temperature and pH will have a significant impact on the reaction process and product yield.

2-Fluoro-3-pyridyl boronic acid has a wide range of uses. In the field of organic synthesis, it is often used as a key intermediate. Due to its unique chemical activity, it can involve a variety of reactions.
In organic synthesis, it is often seen in coupling reactions. Take Suzuki coupling reaction as an example, this is an important means to construct carbon-carbon bonds. 2-fluoro-3-pyridyl boronic acid can be coupled with halogenated aromatics or alkenyl halides under the action of palladium catalyst and base to form fluoropyridine derivatives. Such derivatives are of great significance in the field of medicinal chemistry. Many drug molecular designs require the introduction of specific fluorine-containing structures to change the physicochemical properties, biological activities and metabolic stability of compounds.
In the field of materials science, 2-fluoro-3-pyridyl boronic acid is also used. Special structural organic molecules can be constructed by the reactions it participates in, which can be used to prepare functional materials, such as organic optoelectronic materials. Through rational design of reactions, specific conjugated structures can be formed to regulate the optical and electrical properties of materials, providing the possibility for the development of new optoelectronic materials.
In addition, in pesticide chemistry, fluorine-containing pyridine structure compounds have many good biological activities. As a key raw material for the synthesis of such compounds, 2-fluoro-3-pyridyboronic acid helps to create high-efficiency, low-toxicity and environmentally friendly pesticides, providing strong support for agricultural pest control and crop protection. In short, 2-fluoro-3-pyridyboronic acid is an indispensable chemical raw material in many fields such as organic synthesis, materials science, medicine and pesticide chemistry, and is of great significance to the development of various fields.

The method of preparing 2-fluoro-3-pyridine boronic acid often follows the following path. First, 2-fluoro-3-halopyridine is used as the starting material, and the halogen atom can be chlorine, bromine or iodine. In a low temperature inert atmosphere, such as under the protection of nitrogen or argon, it is reacted with an organolithium reagent, such as n-butyllithium (n-BuLi). During this process, the organolithium reagent will capture the hydrogen atom in the halogen ortho-position of the halogen atom in the halopyridine to form an active intermediate. Subsequently, borate esters, such as trimethyl borate (B (OMe)), are quickly added, and the intermediates undergo nucleophilic substitution reactions with borate esters to generate corresponding borate derivatives. Finally, after acidic hydrolysis, such as treatment with dilute hydrochloric acid or dilute sulfuric acid, the borate ester is hydrolyzed as the target product 2-fluoro-3-pyridyl boronic acid.
Second, it can also be prepared by palladium-catalyzed coupling reaction. The reaction of 2-fluoro-3-halogenated pyridine with diphenol borate (B ² pin ³) as the reactant, under the action of palladium catalyst, such as tetrakis (triphenylphosphine) palladium (Pd (PPh 🥰)), add an appropriate amount of base, such as potassium carbonate (K ² CO 🥰) or sodium carbonate (Na ² CO 🥰), in a suitable organic solvent, such as dioxane or toluene, heat and stir the reaction. Palladium catalyst activates halogenated pyridine and borate esters, promotes the coupling of the two, forms a boron-containing intermediate, and then hydrolyzes to obtain 2-fluoro-3-pyridyl boronic acid.
These two types of methods are quite commonly used in the field of organic synthesis. They can effectively prepare 2-fluoro-3-pyridyl boronic acid, but they have their own advantages and disadvantages, and they need to be selected according to actual needs and conditions.

2-Fluoro-3-pyridyl boronic acid is a commonly used reagent in organic synthesis. When storing this substance, many key points must be paid attention to.
Bear the brunt, temperature is crucial. It should be stored in a low temperature environment, usually refrigerated at 2-8 ° C. Due to high temperature, or the chemical reaction of the compound occurs, causing it to deteriorate and reduce its activity, which affects the subsequent use effect.
Second, the humidity cannot be ignored. This reagent is very easy to absorb moisture. Once it gets wet, it may cause adverse reactions such as hydrolysis and destroy its chemical structure. Therefore, it should be stored in a dry place. It can be placed in a storage container with the help of a desiccant, such as silica gel, to maintain a dry environment.
Furthermore, light will also affect 2-fluoro-3-pyridyl boronic acid. Long-term light exposure, or a chemical reaction caused by luminescence, causes its properties to change. Therefore, it needs to be stored in a dark place, or stored in a light-shielding container such as a brown bottle to avoid light interference.
In addition, the choice of storage container is also very critical. Containers with stable chemical properties and no reaction with 2-fluoro-3-pyridyl boronic acid must be selected. Common glass bottles or plastic bottles can be used if the material is suitable. However, it is necessary to ensure that the container is well sealed to prevent air, moisture, etc. from entering.
In short, when storing 2-fluoro-3-pyridyl boronic acid, it is necessary to strictly control factors such as temperature, humidity, light, and storage containers, so as to ensure the quality and activity of the reagent, so that it can play its due role in organic synthesis and other fields.

The market price of 2-fluoro-3-pyridyl boronic acid is difficult to have an exact number, because many factors interact with each other. Looking at the state of the market in the past, the price of this chemical material often fluctuated like waves, and there was no constant price.
First, the trend of supply and demand has a huge impact on price fluctuations. If there is a surge in demand at a certain time, many companies compete to buy this product, and the supply is relatively scarce, just like the reason that rare things are expensive, the price should rise. On the contrary, if the supply is abundant, the demand is sluggish. If the goods are hoarded and few people care about them, the price will tend to fall.
Second, the cost of production also affects the price. If the price of raw materials fluctuates, the production cost of this product will also change accordingly. If the price of raw materials rises, the manufacturer will raise the price to sell it in order to ensure profitability. Furthermore, the difficulty of the production process, if the process is complex, it requires a lot of manpower, material and financial resources to maintain production, the cost will increase, and the price will also be difficult to lower.
Third, the state of market competition is also related to the price. If there are many merchants producing this product in the market, and the competition is fierce with each other, in order to compete for customers, there may be merchants who reduce prices and promote. On the contrary, if the market is almost monopolized, only a few merchants control the supply, and the price may be dominated by them, it is difficult to have a low price.
Comprehensive consideration, the market price of 2-fluoro-3-pyridyl boronic acid often varies from place to place. To know the exact price in the near future, it is necessary to carefully observe the current market supply and demand, cost and competition conditions, and cannot be generalized.