2-FLUORO-3-NITRO-4-PICOLINE (2-FLUORO-4-METHYL-3-NITROPYRIDINE)

2-Fluoro-3-nitro-4-methylpyridine (2-fluoro-4-methyl-3-nitropyridine) is widely used. In the field of medicinal chemistry, it is often used as a key intermediate to help create many specific drugs. For example, when synthesizing a new type of antibacterial drug with unique physiological activity, it can participate in a complex reaction process with its own special chemical structure. After multiple steps of delicate transformation, a molecular structure with precise antibacterial targeting can be constructed.
In the development of pesticides, it is also an indispensable and important raw material. It can be used to create highly efficient and low-toxic pesticides, fungicides and other pesticide products. Through ingenious chemical modifications and reactions, it is combined with specific biological targets to achieve precise strikes against pests and pathogens, ensuring the growth of crops while minimizing the harm to the environment.
In addition, in the field of materials science, it also shows unique value. It can be used as a starting material for synthesizing functional materials, and carefully designed polymerization reactions or other chemical processes give materials such as special optical and electrical properties, opening up new paths for the development of new functional materials.

2-Fluoro-3-nitro-4-methylpyridine (2-Fluoro-4-methyl-3-nitropyridine) is an organic compound with specific physical properties. It is mostly solid or liquid at room temperature, and its appearance may be colorless to light yellow. It has a certain color due to the conjugation system and specific functional groups.
This compound has a specific melting point and boiling point. The melting point is the temperature at which a substance changes from a solid state to a liquid state. The boiling point is the temperature at which it changes from a liquid state to a gas state. However, the exact value needs to be consulted in professional literature or measured by experiments. Its melting point and boiling point are affected by intermolecular forces, such as hydrogen bonds, van der Waals forces, etc. Containing fluorine, nitro and methyl groups, it will affect the intermolecular force, which in turn affects the melting boiling point.
The solubility of 2-fluoro-3-nitro-4-methylpyridine is also an important physical property. Its solubility is good in organic solvents such as ethanol and acetone. Due to the principle of similar miscibility, the compound is similar to the polarity of organic solvents. However, its solubility in water is limited. Because it is not a strongly polar molecule, it has a weak ability to form hydrogen bonds with water.
In addition, the density of this compound is related to practical application. The density is per unit volume mass. The density may vary under different conditions, and it usually needs to be accurately determined by experiments. Its density is affected by the molecular structure and the close arrangement between molecules.
The compound also has a certain vapor pressure. Vapor pressure refers to the pressure of vapor that is in equilibrium with a liquid or solid at a certain temperature. When the temperature increases, the vapor pressure increases. This property is of great significance to its existence state and volatilization degree in different environments.
The physical properties of 2-fluoro-3-nitro-4-methylpyridine have a profound impact on its synthesis, separation, storage and application, and are of great significance in the fields of chemistry and pharmacy.

To prepare 2-fluoro-3-nitro-4-methylpyridine (2-fluoro-4-methyl-3-nitropyridine), the following method is often followed.
Take 4-methylpyridine as the starting material, which is the raw material of the base. Place it in a suitable reaction vessel, add an appropriate amount of solvent, such as dichloromethane, chloroform, etc., to create a homogeneous reaction environment, so that the reaction can proceed smoothly.
Then, under low temperature and sufficient stirring, slowly add fluorine-containing reagents, such as Selectfluor, etc. This step aims to introduce fluorine atoms into the pyridine ring. The activity of fluorine reagents is quite high, and the low temperature and slow addition method can make the reaction smooth and prevent it from being too violent to cause side reactions. In this process, the reaction temperature and reaction progress need to be closely monitored, which can be observed by thin layer chromatography (TLC) or other suitable analytical methods.
After the fluorine substitution reaction is completed, the temperature of the reaction system is moderately increased, and then a nitrifying reagent is added, such as mixed acid (a mixture of nitric acid and sulfuric acid). With the help of sulfuric acid, nitric acid generates nitroyl positive ion (NO ²), which is an electrophilic reagent and can attack specific positions on the pyridine ring. Due to the localization effect of methyl and fluorine atoms on the pyridine ring, nitroyl positive ions will mostly attack the position of methyl ortho-sites and fluorine interatomic sites, and then form the target product 2-fluoro-3-nitro-4-methylpyridine.
After the reaction is completed, the product needs to be separated and purified. The reaction solution is first poured into ice water, the reaction is terminated, and then the product is extracted with an organic solvent. The extract is dried with anhydrous sodium sulfate to remove the water in it, and then the solvent is removed by rotary evaporation. Finally, by column chromatography, the product was further purified with a suitable eluent, such as the mixture of petroleum ether and ethyl acetate, to obtain pure 2-fluoro-3-nitro-4-methylpyridine.

When storing and transporting 2-fluoro-3-nitro-4-methylpyridine (2-fluoro-4-methyl-3-nitropyridine), many things need to be paid attention to.
This compound has special properties and must be stored in a dry and cool place. Because it is quite sensitive to moisture and easy to deteriorate in a humid environment, the humidity in the warehouse should be controlled at a low level, and good ventilation should be ensured to prevent the accumulation of harmful gases. The temperature should not be too high, high temperature or cause it to decompose, or cause danger.
Furthermore, when storing, it should be stored separately from oxidizing substances, acids, bases, etc. This compound is chemically active and in contact with the above substances, it is easy to cause chemical reactions, or cause serious consequences such as fire and explosion.
When transporting, the packaging must be strong and reliable. Make sure that the packaging is free from the risk of leakage to prevent its leakage from polluting the environment and endangering the health of others. Transportation vehicles should also have good ventilation conditions, and transportation personnel need to be professionally trained to be familiar with its characteristics and emergency treatment methods. If a leak occurs during transportation, the scene should be quickly isolated, the crowd should be evacuated, and appropriate measures should be taken to deal with the leak to avoid the spread of pollution. In short, the storage and transportation of 2-fluoro-3-nitro-4-methylpyridine should be strictly operated in accordance with regulations, treated with caution, and must not be taken lightly to ensure the safety of personnel and the environment.

2-FLUORO-3-NITRO-4-PICOLINE that is, 2-fluoro-3-nitro-4-methylpyridine (2-fluoro-4-methyl-3-nitropyridine), the market price range of this product is often changed due to many factors.
First, the preparation process is complicated and simple. If the preparation requires complicated steps, high raw materials or harsh reaction conditions, the cost will be high, and the price will also rise. Second, the market supply and demand situation has a great impact. If the demand is strong and the supply is limited, the price may rise; if the supply is abundant and the demand is weak, the price may decline. Third, product purity is crucial. High-purity products are often more expensive than low-purity products because of their high purification requirements.
According to past market conditions and related information, the price of this chemical per gram may range from tens to hundreds of yuan. For small-scale scientific research purposes, products with extremely high purity requirements, the price per gram may be nearly 100 yuan or even higher. For industrial production, those with slightly lower purity requirements may be relatively close to the people, or tens of yuan per gram.
However, the market is changing, and raw material prices fluctuate, policies and regulations change, production technology innovation, etc., can cause their prices to fluctuate. To know the exact price range, it is advisable to consult relevant chemical product suppliers, browse chemical product trading platforms, or communicate with industry insiders to obtain current accurate price information.