2-Fluoro-3-methylpyridine-5-boronic acid

2-Fluoro-3-methylpyridine-5-boronic acid, which is an extremely important reagent in organic synthesis, is widely used in many fields.
First, in the field of medicinal chemistry, its use is quite critical. Due to the unique biological activity of compounds containing pyridine structures, this boric acid can be used as a key intermediate to construct fluoropyridine-containing drug molecules with diverse structures. By Suzuki-Miyaura coupling reaction with other organic halides, specific functional groups can be precisely introduced to optimize the activity, selectivity and pharmacokinetic properties of drug molecules. For example, it may be used to develop new antibacterial and anti-tumor drugs, making great contributions to human health.
Second, in the field of materials science, it also shows extraordinary value. It can be introduced into the skeleton of polymer materials by chemical reaction. Due to the characteristics of fluorine atoms, it can effectively improve the thermal stability, chemical stability and optical properties of materials. Such as the preparation of high-performance luminescent materials, liquid crystal materials, etc., providing strong support for the development of modern science and technology.
Third, in the field of organic synthesis chemistry, as an important boron reagent, it provides a convenient and efficient way to construct complex organic molecules. The coupling reaction conditions it participates in are relatively mild and the selectivity is good. It can achieve the precise synthesis of a variety of complex structures, which greatly enriches the strategies and methods of organic synthesis, and helps chemists to create more novel and specific organic compounds.
In short, 2-fluoro-3-methylpyridine-5-boronic acid plays a pivotal role in many cutting-edge fields such as drug development, material innovation and organic synthesis, and plays an important role in promoting the development of various fields.

The synthesis methods of 2-fluoro-3-methylpyridine-5-boronic acid are many different, and the common ones are as follows.
First, the halogenated pyridine derivative is used as the starting material. First, take the corresponding halogenated pyridine, such as 2-fluoro-3-methyl-5-halogenated pyridine, and react with organometallic reagents, such as n-butyllithium, at low temperature and in an anhydrous and oxygen-free environment. This reaction can replace the halogen atom with a metal group to form a lithium intermediate. Then, this intermediate is reacted with borate esters, such as trimethyl borate, under appropriate conditions. After the reaction is completed, 2-fluoro-3-methylpyridine-5-boronic acid can be obtained through the hydrolysis step. In this method, low temperature and anhydrous and anaerobic environment are extremely critical to ensure the smooth progress of the reaction and reduce the occurrence of side reactions.
Second, pyridine compounds are used as starting materials and synthesized through a multi-step reaction. Pyridine is methylated at a specific position first, and a methyl group is introduced. After that, a fluorine atom is introduced at an appropriate position, and then a boronic acid group is introduced through a boration reaction. In this process, the reaction conditions of each step need to be carefully adjusted. For example, in methylation reactions, appropriate methylation reagents and reaction solvents need to be selected. During boration reactions, the activity of boronation reagents and the influence of reaction conditions on product selectivity should also be considered.
Third, transition metal catalysis. Using suitable pyridine derivatives as substrates, in the presence of transition metal catalysts, such as palladium catalysts, with boron-containing reagents, such as diphenol borate, etc. This reaction condition is relatively mild and highly selective. During the reaction, factors such as catalyst loading, ligand selection, and reaction temperature and time will all affect the reaction results. The yield and purity of the target product 2-fluoro-3-methylpyridine-5-boronic acid should be improved by optimizing these reaction parameters.

2-Fluoro-3-methylpyridine-5-boronic acid, a white to off-white solid, is quite stable at room temperature and pressure. Its melting point is usually between 120 ° C and 125 ° C, which can help to identify and purify this compound.
When it comes to solubility, it is slightly soluble in water, but it exhibits good solubility in common organic solvents such as dichloromethane, chloroform, ethanol and acetone. This solubility property is significant in organic synthesis because it allows the boric acid to be fully dissolved in different reaction systems, and then participates in various chemical reactions.
From the perspective of chemical activity, the boron atom contained in 2-fluoro-3-methylpyridine-5-boronic acid has empty orbitals, which makes it a good receptor for electrophilic reagents and can participate in many important reactions. For example, in the Suzuki coupling reaction, it can react with halogenated aromatics or alkenyl halides under the action of palladium catalysts and bases to form carbon-carbon bonds, which is undoubtedly a critical reaction path for the synthesis of complex organic molecules, pharmaceutical intermediates, and functional materials. In addition, due to the presence of fluorine atoms and methyl groups on the pyridine ring, they will affect the electron cloud density at the check point of the reaction, so that the boric acid exhibits unique regioselectivity and chemical selectivity when participating in the reaction.

2-Fluoro-3-methylpyridine-5-boronic acid requires attention to many matters when storing and transporting. This compound is more active in nature and is quite sensitive to environmental factors.
When storing, the first thing to dry. Because of its boric acid structure, it is easy to absorb moisture. If the ambient humidity is high, it is easy to cause deliquescence and deterioration. It should be stored in a dry place, and the storage environment can be maintained dry with the help of desiccant. Secondly, temperature is also critical. It should be stored in a low temperature environment, usually 2-8 ° C. High temperature will accelerate its chemical reaction rate, promote decomposition or other side reactions, and reduce its purity. And it needs to be kept away from fire and heat sources, because it may be flammable or easily decomposed by heat, causing safety accidents.
When transporting, the packaging must be tight. Appropriate packaging materials should be used to ensure that it is not affected by vibration and collision during transportation, and to prevent leakage due to package damage. And the internal environment of the means of transportation should also be controlled to keep it dry and low temperature. At the same time, transporters need to know the characteristics of this compound, follow the relevant dangerous chemical transportation regulations during transportation, and prepare for emergency measures in case of leakage or other accidents, so that they can respond in a timely and effective manner and reduce hazards. In this way, the stability and safety of 2-fluoro-3-methylpyridine-5-boronic acid during storage and transportation can be ensured.

2-Fluoro-3-methylpyridine-5-boronic acid, the market price of this substance is difficult to say in a word. The price of this substance is influenced by many factors, and it is unpredictable.
Let's talk about the end of the raw material first. The price of various starting materials required for its preparation fluctuates. If the source of raw materials is scarce, or the process of obtaining them is difficult and complicated, requiring a lot of manpower, material and financial resources, the price of raw materials is bound to be high, which will cause the cost of 2-fluoro-3-methylpyridine-5-boronic acid to rise, which in turn will increase its market price.
Furthermore, the production process is also the key. The delicate and efficient process can reduce the loss of the production process, improve the output efficiency, and reduce the cost. However, if the process is still immature, or the operation is difficult, special equipment and technology are required, the cost will also increase, and the price will also change.
The situation of market supply and demand is also the main reason for the price. If the market demand for 2-fluoro-3-methylpyridine-5-boronic acid is strong, but the supply is relatively insufficient, if the demand for it in some industries surges, and the manufacturer cannot meet it for a while, the price will rise. On the contrary, if the market demand is low and the supply is excessive, the manufacturer may reduce the price in order to sell.
In addition, the brand and reputation of the manufacturer are also related to the price. Well-known large factories are known for their stable quality and outstanding reputation, and their products may be priced higher. And new factories, in order to compete for market share, may attract customers with lower prices.
To know the exact market price, when you check the chemical product trading platform, consult the industry merchants, or communicate with relevant manufacturers, you can obtain relatively accurate price information to meet your needs.