2-FLUORO-3-IODO-5-PICOLINE (2-FLUORO-3-IODO-5-METHYLPYRIDINE)

2-Fluoro-3-iodo-5-methylpyridine (2-Fluoro-3-iodo-5-methylpyridine) is widely used. In the field of pharmaceutical synthesis, it is often used as a key intermediate. Due to its unique structure, it contains special atoms such as fluorine and iodine, which endow it with specific chemical and biological activities. Based on this, many compounds with unique pharmacological properties can be derived for the development of new drugs, or for antibacterial, anti-cancer, or neurological diseases, with broad prospects.
In the field of materials science, it also has extraordinary performance. Due to its structure endowing molecules with specific electronic properties and spatial configurations, it can be used to prepare functional organic materials. For example, when applied to organic Light Emitting Diode (OLED) materials, it may improve the luminous efficiency and stability of the materials and enhance the display performance. Furthermore, in the preparation of sensor materials, it may be possible to use its selective interaction with specific substances to construct highly sensitive and highly selective chemical sensors for detecting environmental pollutants, biomarkers, etc.
In addition, in the field of organic synthesis chemistry, as an important building block, with the activity check point of fluorine, iodine and pyridine rings, complex organic molecular structures can be constructed through various organic reactions, such as coupling reactions, nucleophilic substitution reactions, etc., to expand the diversity of organic synthesis and provide strong support for organic chemistry research and innovation.

2-Fluoro-3-iodine-5-methylpyridine, this is an organic compound. Its physical properties are particularly important and are related to many chemical applications.
Looking at its appearance, it is mostly colorless to light yellow liquid at room temperature and pressure, but it is also slightly different due to impurities or preparation methods. The color of this compound, like the light of the yellowish morning light, vaguely reveals the uniqueness of its internal chemical structure.
When it comes to boiling points, it is about a relatively high range. Due to the presence of certain forces between molecules, high energy is required to convert it from liquid to gas. This property is crucial when separating and purifying, just like finding a precise route in a complex maze to obtain a pure thing.
In terms of melting point, there is also a specific value. At a specific temperature, it will change from a solid state to a liquid state. This temperature is its inherent property, just like the unique "code" given to it by the chemical world.
Furthermore, solubility is also an important physical property. In organic solvents, such as common ethanol, ether, etc., it exhibits a certain solubility. This property is similar to its adaptability in different "environments". In organic synthesis reactions, it can be dissolved in suitable solvents and fully contact and react with other reactants, just like a dancer cooperating with a dance partner on stage to perform a wonderful chemical "dance".
And density, compared to water, has a specific ratio. Either greater than water or less than water, this characteristic can be used as an important basis in operations such as liquid-liquid separation, just as clever use of the balance principle at both ends of the balance to achieve effective separation of substances.
In addition, its vapor pressure also varies at different temperatures. Vapor pressure reflects the degree of difficulty of volatilization. Under specific conditions, it may be easy to evaporate or relatively stable. This needs to be taken into account during storage and transportation to ensure that its chemical properties are not disturbed by the outside world, just like carefully creating a suitable "small world" for it.

The synthesis of 2-fluoro-3-iodo-5-methylpyridine (2-fluoro-3-iodo-5-methylpyridine) is an important research topic in the field of organic synthesis. Its synthesis path is often achieved by multi-step reactions in sequence.
The starting materials are mostly based on compounds containing pyridine rings. For example, 5-methylpyridine is used as the starting material, because of its structure of pyridine ring and methyl group, it lays the foundation for the subsequent introduction of fluorine and iodine atoms.
The first step of the reaction is often the introduction of fluorine atoms. This step can be used by nucleophilic substitution reaction. Under appropriate reaction conditions, fluorine-containing reagents, such as potassium fluoride, are used to react with 5-methylpyridine. The reaction system requires a suitable solvent, such as dimethyl sulfoxide (DMSO), because it can dissolve raw materials and reagents to promote the reaction. And the reaction temperature and time need to be controlled. Generally, under heating conditions, the reaction takes several hours to make fluorine atoms replace hydrogen atoms at specific positions on the pyridine ring to obtain 2-fluoro-5-methylpyridine.
The second step of the reaction is the introduction of iodine atoms. This step is mostly an iodization reaction. Combine iodine reagents, such as iodine elemental substance (I _ 2), with appropriate oxidants, such as hydrogen peroxide (H _ 2O _ 2). In an acidic environment, such as acetic acid solution, the reaction is carried out. Iodine atoms form active intermediates under the action of oxidants, and then replace hydrogen atoms at specific positions on 2-fluoro-5-methylpyridine to obtain the target product 2-fluoro-3-iodine-5-methylpyridine. During the reaction process, the temperature, reagent ratio and reaction time need to be precisely controlled to improve the yield and purity of the product.
There are also other synthesis ideas. For example, iodine atoms are introduced first, followed by fluorine atoms. However, this path needs to consider the reactivity of different positions on the pyridine ring and the effect of each step on the subsequent reaction. In the synthesis process, after each step of the reaction, it is often necessary to undergo separation and purification operations, such as column chromatography, recrystallization, etc., to remove impurities and obtain a pure product, ensuring the quality and purity of the final product, and meeting the needs of experimental or industrial production.

When storing and transporting 2-fluoro-3-iodine-5-methylpyridine, many things need to be paid attention to.
First, because of its active chemical properties, it is easy to react with surrounding substances, so it must be placed in a dry, cool and well-ventilated place. Moisture can easily cause it to hydrolyze, and excessive temperature may cause it to decompose and deteriorate. Be sure to avoid environmental moisture and high temperature.
Second, this substance is toxic and corrosive to a certain extent. During operation, protective measures must be taken. When taking it, wear protective clothing, protective gloves and goggles to prevent contact with skin and eyes and cause damage. In case of accidental contact, immediately rinse with a large amount of water, and according to the severity of the injury, seek medical treatment in time.
Furthermore, during transportation, be sure to ensure that the packaging is tight to prevent leakage. Select appropriate packaging materials, such as corrosion-resistant containers, and properly fix them to avoid collision and vibration, resulting in package damage. In the event of a leak, personnel should be evacuated quickly, the scene should be isolated, and corresponding emergency measures should be taken according to the amount of leakage. A small amount of leakage can be absorbed by inert materials such as sand and vermiculite; a large amount of leakage requires construction of a dike or digging a pit for containment, and then professional treatment.
In addition, fireworks are strictly prohibited at storage and transportation sites. Because of its flammability, in case of open flame, hot topic, there is a risk of combustion and explosion. And it must be stored separately from oxidants, acids, bases, etc., and must not be mixed in storage and transportation to prevent violent chemical reactions and endanger safety.
Only by paying careful attention to the above matters and operating in strict accordance with regulations can we ensure the safety of 2-fluoro-3-iodine-5-methylpyridine during storage and transportation.

The market price range of 2-fluoro-3-iodine-5-methylpyridine varies depending on a variety of factors. For the chemical raw material market, like many fine chemicals, the price is deeply affected by the cost of raw materials, the difficulty of synthesis process, market supply and demand conditions, production scale and purity requirements.
In the past, if raw materials were easily available and the synthesis process was mature, the price would be relatively close to the people when mass production was carried out. However, if raw materials were scarce or the synthesis steps were complicated, specific reaction conditions and high-end technologies were required, and the cost would increase and the price would also rise.
From the perspective of supply and demand, when the market demand for 2-fluoro-3-iodine-5-methylpyridine is strong and the supply is limited, the price will rise; on the contrary, when the supply exceeds the demand, the price may decline.
Furthermore, product purity has a great impact on the price. High-purity products usually cost more than ordinary purity products due to the need for finer purification processes. According to past market conditions, the price per gram for ordinary purity may be in the tens of yuan; if it is high purity, up to 98% or more, the price per gram may exceed 100 yuan, or even higher, depending on the actual market changes.