2-FLUORO-3-(HYDROXYMETHYL)PYRIDINE

2-Fluoro-3- (hydroxymethyl) pyridine, an organic compound, has important uses in many fields.
In the field of medicinal chemistry, it has a wide range of uses. Due to its unique chemical structure, it can be used as a key intermediate for the synthesis of various drugs. In many drug development processes, this compound can provide the basis for the construction of specific structures of drug molecules, which in turn endows drugs with unique pharmacological activities. For example, in the synthesis of some antibacterial and antiviral drugs, 2-fluoro-3- (hydroxymethyl) pyridine can participate in key reaction steps, which is of great significance for the optimization of drug activity and selectivity.
In the field of materials science, it also has its own uses. It can be used as a raw material or additive to prepare materials with special properties. For example, when preparing some functional polymer materials, introducing them into the polymer structure can improve the electrical properties, optical properties or mechanical properties of the materials, providing the possibility for the development of new functional materials.
In the field of organic synthetic chemistry, 2-fluoro-3- (hydroxymethyl) pyridine is an important building block. Organic chemists can use it to perform various chemical reactions, such as nucleophilic substitution reactions, oxidation-reduction reactions, etc., to construct more complex organic molecular structures. Through ingenious design of reaction routes, a series of organic compounds with different functional groups and structures can be synthesized using this compound, providing a rich material basis for the development of organic synthetic chemistry.

2-Fluoro-3- (hydroxymethyl) pyridine is a kind of organic compound. Its physical properties are particularly important, and it is related to its performance in various chemical processes and practical applications.
When it comes to properties, 2-fluoro-3- (hydroxymethyl) pyridine is often colorless to pale yellow liquid at room temperature. This color feature is convenient for visual identification in experiments and production. Its smell has a special smell, although it is difficult to describe exactly, but it can be preliminarily determined by people familiar with this compound.
Looking at its boiling point, due to the intermolecular force, the boiling point is within a certain range. This property is crucial for the separation and purification of this compound. When heated to a specific temperature, 2-fluoro-3- (hydroxymethyl) pyridine will change from liquid to gaseous state, and pure matter can be collected by means of condensation. Its melting point is also a key physical property, which determines the temperature at which it changes from solid to liquid state. The value of the melting point helps researchers plan the storage and use conditions.
In terms of solubility, 2-fluoro-3- (hydroxymethyl) pyridine exhibits good solubility in some organic solvents, such as ethanol and ether. This is due to the specific interactions between the molecular structure and the organic solvent molecules, such as hydrogen bonds, van der Waals forces, etc. In water, its solubility is relatively limited. This difference is an important basis for selecting suitable solvents in extraction, phase transfer and other operations.
Density is also one of its physical properties. Its density value reflects the mass per unit volume and is indispensable for accurate measurement and mixing of different substances. Accurate knowledge of density can ensure accurate material consumption in experiments and production processes.
In addition, the refractive index of 2-fluoro-3- (hydroxymethyl) pyridine is also one of its physical characteristics. This property can be used as a reference for identification and purity determination in optics-related applications or analytical testing. In summary, the physical properties of 2-fluoro-3- (hydroxymethyl) pyridine, such as color, odor, melting point, solubility, density, and refractive index, are of great significance in chemical research, industrial production, and many other fields.

2-Fluoro-3- (hydroxymethyl) pyridine is an organic compound with unique chemical properties.
It is basic, because the nitrogen atom of the pyridine ring contains lone pairs of electrons, it can accept protons. In acidic media, nitrogen atoms are easily protonated to form pyridine cations. This characteristic is used in organic synthesis. It can be used as a base to participate in many reactions, such as catalyzing some nucleophilic substitution reactions, which promotes the smooth progress of the reaction.
The compound is hydrophilic, because it contains hydroxymethyl groups. Hydroxyl groups can form hydrogen bonds with water molecules to improve their solubility in water. This property is of great significance in the field of drug development. Good water solubility is conducive to the transmission and metabolism of drugs in organisms and improves bioavailability.
At the same time, the fluorine atom of 2-fluoro-3- (hydroxymethyl) pyridine has a great influence on the distribution of molecular electron clouds due to its high electronegativity. The fluorine atom induction effect reduces the electron cloud density of the pyridine ring, changes the activity of the electrophilic substitution reaction on the ring, and is more inclined to react at a specific position, providing an opportunity for selective reactions in organic synthesis. For example, in the halogenation reaction, it can guide the reaction to check point selectivity and synthesize derivatives with specific structures.
Furthermore, the hydroxyl group of hydroxymethyl group is active and prone to various chemical reactions. It can be esterified with acids to form corresponding ester compounds; under the action of appropriate oxidants, it can be oxidized to aldehyde or carboxyl groups, expanding the structural diversity of compounds, and laying the foundation for the preparation of materials with different functions in the fields of fine chemistry and materials science.
In short, the basic, hydrophilic and reactive activities of 2-fluoro-3- (hydroxymethyl) pyridine make it useful in organic synthesis, pharmaceutical chemistry, materials science and other fields. Chemists can use its unique properties to design and synthesize various compounds with specific functions.

There are several ways to synthesize 2-fluoro-3- (hydroxymethyl) pyridine. First, fluorine atoms and hydroxymethyl groups can be introduced through a specific substitution reaction starting from the starting material containing the pyridine structure. In this process, a halogenation reaction is performed at a specific position of the pyridine ring to introduce a halogen atom, such as chlorine or bromine, and then the halogen atom is replaced by a fluoride by a nucleophilic substitution reaction to obtain a fluorine-containing pyridine intermediate. As for the introduction of hydroxymethyl groups, formaldehyde or its equivalent reagents are often used to undergo nucleophilic addition reactions with the active check points on the pyridine ring under suitable basic conditions, so as to obtain the target product.
Second, it can be achieved through the strategy of constructing pyridine rings. For example, the pyridine ring is formed by condensation reaction with suitable nitrogen-containing and carbon-containing compounds, such as β-ketone esters and ammonia or amine compounds. In this process, the structure of the reactants is cleverly designed, so that fluorine atoms and hydroxymethyl groups are pre-planned in the reactants, and the pyridine ring of the target molecule and the required substituent are constructed together during the cyclization reaction.
Third, the reaction catalyzed by transition metals is also feasible. Using halogenated pyridine derivatives as substrates, under the action of transition metal catalysts such as palladium and nickel, the coupling reaction occurs with fluorine-containing reagents and hydroxymethylation reagents. This method requires precise regulation of reaction conditions, such as temperature, ligand selection, etc., to achieve efficient and selective synthesis. Different synthesis methods have their own advantages and disadvantages. It is necessary to carefully choose the appropriate synthesis path according to the actual situation, considering the availability of raw materials, the difficulty of reaction conditions, yield and selectivity and many other factors.

The price of 2-fluoro-3- (hydroxymethyl) pyridine in the market varies depending on many factors. Looking at the price state of chemical materials in the past, it was often restricted by the state of supply and demand, the difficulty of manufacturing, the price of raw materials, and current policies.
If the supply and demand are balanced, the supply of this material is sufficient and the demand is also stable, and its price may be stable. However, if the supply is not enough to meet the demand, in case of a sudden rise in downstream industries, the demand will increase sharply, and the producer will not respond quickly, and the price will rise. On the contrary, if the production is more and less, the price will drop.
The difficulty of manufacturing is also a major factor. If the preparation of it requires complex, high technology, or consumes a huge amount of energy, the cost will be high, and the price will follow. If new technologies are developed to make it easy and cheap, the price may decline.
The price of raw materials is also related to its price. If raw materials are scarce, or their production is affected by natural disasters and political regulations, the price will rise, causing the price of 2-fluoro-3- (hydroxymethyl) pyridine to also rise.
The current situation and policy are also involved. If environmental protection is stricter, producers need to increase environmental protection inputs, and the cost will increase and the price will increase. Or if there are supportive policies, drum production promotion, the price may drop.
In summary, the price of 2-fluoro-3- (hydroxymethyl) pyridine in the market today is in the range of hundreds to thousands of yuan per kilogram, but this is only an approximate estimate. The exact price should be consulted with chemical suppliers to check the real-time market.