2-Fluoro-3-Chloro-5-Bromopyridine

2-Fluoro-3-chloro-5-bromopyridine is an organic compound with a wide range of uses. In the field of medicinal chemistry, it is often used as a key intermediate to help create various drugs. The structure of the Gainpyridine ring is stable and has unique electronic properties. The introduction of fluorine, chlorine and bromine atoms endows the compound with different physical and chemical properties and biological activities. For example, when developing antibacterial drugs, the compound structure can be modified to enhance the affinity and inhibitory effect of the drug on specific bacteria, and can also be used to develop innovative drugs for the treatment of cardiovascular diseases, neurological diseases, etc.
In the field of materials science, 2-fluoro-3-chloro-5-bromopyridine also has important applications. First, it can participate in the synthesis of functional materials, such as organic semiconductor materials. The presence of pyridine rings and halogen atoms can regulate the electron transport properties of materials, which are suitable for organic Light Emitting Diode (OLED), organic field effect transistor (OFET) and other devices to improve their luminous efficiency and carrier mobility. Second, in the preparation of high-performance polymer materials, this compound can be used as a comonomer. By polymerizing with other monomers, it can give the polymer special properties, such as improving the thermal stability and chemical stability of the material, and is used in aerospace, electronics and other fields that require strict material properties.
In the field of pesticide chemistry, 2-fluoro-3-chloro-5-bromopyridine is also indispensable. Based on it, high-efficiency, low-toxicity and environmentally friendly pesticides can be developed. With its unique structure and activity, it can accurately act on specific targets of pests, interfere with their physiological activities, achieve good insecticidal, bactericidal or weeding effects, and reduce the negative impact on non-target organisms and the environment, meeting the needs of the current development of green agriculture.

2-Fluoro-3-chloro-5-bromopyridine is a crucial compound in the field of organic synthesis. Its physical properties are as follows:
Under normal temperature and pressure, 2-fluoro-3-chloro-5-bromopyridine is usually a colorless to pale yellow liquid, or a crystalline solid. This form varies depending on the specific purity and environmental conditions.
When it comes to the melting point, according to many experimental data and research literature, it is about a specific temperature range. However, due to different preparation methods and differences in impurities contained, the melting point data may fluctuate slightly.
In terms of boiling point, there are also corresponding values. The boiling point of the compound reflects the energy required to transform from liquid to gaseous state. In the distillation and separation steps of organic synthesis, the boiling point is one of the key factors to consider.
As for solubility, 2-fluoro-3-chloro-5-bromopyridine exhibits good solubility in common organic solvents such as dichloromethane, chloroform, and ether. This property allows it to be fully mixed with various reactants in an organic reaction system, effectively promoting the progress of the reaction. In water, its solubility is relatively limited, which is determined by the molecular structure of the compound. The polarity of its molecules is quite different from that of water molecules, so it is difficult to dissolve in water.
In addition, the density of 2-fluoro-3-chloro-5-bromopyridine is also a specific value, which is indispensable for accurate measurement and the design and operation of specific reaction systems.
The physical properties of 2-fluoro-3-chloro-5-bromopyridine play a key role in many fields such as organic synthesis and drug development. The accurate grasp of its properties is conducive to more efficient scientific research and production.

The chemical synthesis of 2-fluoro-3-chloro-5-bromopyridine is a key issue in the field of organic synthesis. To synthesize this compound, the following steps can be followed.
The first step is to select suitable starting materials. Pyridine and its derivatives are often the basic raw materials for synthesizing pyridine compounds. In view of the distribution of halogen atoms in the target product, pyridine derivatives with specific substituents can be selected as starting materials. This is the cornerstone of synthesis and is related to whether the subsequent reaction can proceed smoothly.
The second step is to introduce fluorine atoms. Generally speaking, nucleophilic substitution reactions can be used. For example, a fluorine-containing reagent reacts with the starting material under suitable reaction conditions. Fluorine-containing reagents such as potassium fluoride are commonly used. In an organic solvent, under the condition of heating and adding a catalyst, fluorine atoms are induced to replace specific groups in the raw material and successfully introduce fluorine atoms. This step requires careful control of the reaction temperature, time and reagent dosage to ensure the selectivity and yield of the reaction.
The third step is to introduce chlorine atoms. It can be achieved by electrophilic substitution reaction. Commonly used chlorination reagents include phosphorus oxychloride. The product of the fluorination reaction is mixed with the chlorination reagent. Under specific reaction conditions, the chlorine atoms in the chlorination reagent will selectively replace specific positions on the pyridine ring to form chlorine-containing intermediates. In this process, the pH of the reaction system, reaction temperature and other factors have a great influence on the reaction process and must be carefully regulated.
At the end of the last step, bromine atoms are introduced. Usually brominating reagents, such as N-bromosuccinimide (NBS), are used to replace hydrogen atoms at the target position through free radical substitution reaction or electrophilic substitution reaction to obtain 2-fluoro-3-chloro-5-bromopyridine. This step requires attention to the reaction initiation conditions and the monitoring of the reaction process to prevent excessive reactions or side reactions.
The process of synthesizing 2-fluoro-3-chloro-5-bromopyridine requires precise control of the reaction conditions at each step. Through rational selection of raw materials and reagents, and careful planning of the reaction sequence, the target product can be obtained efficiently and with high purity.

Looking at this question, I am inquiring about the market price range of 2-fluoro-3-chloro-5-bromopyridine. However, the price of this compound often changes for a variety of reasons, and it is difficult to determine a fixed price range.
The first to bear the brunt, the difficulty of preparation affects the price. If the preparation requires complicated processes and rare raw materials, the price must be high. Complex processes require exquisite operation and special equipment, and rare raw materials are not easy to obtain, which increases their costs.
Furthermore, market supply and demand determine the price. If there are many people seeking this product, but there are few suppliers, the price will rise; conversely, if the supply exceeds the demand, the price will decline.
In addition, the scale of production is also the key. Large-scale production can often reduce costs by means of scale effects, and the price may be relatively easy; small-scale production, the cost is difficult to reduce, and the price may be high.
There is also a reason for purity. High purity of 2-fluoro-3-chloro-5-bromopyridine, due to the need for a more refined purification process, the price should be higher than that of low purity.
Therefore, in order to know the exact price range, it is necessary to carefully consider various factors in the current market, or consult the merchants and market survey agencies specializing in such chemicals to obtain a more accurate price range.

2-Fluoro-3-chloro-5-bromopyridine is an organic compound, and its storage conditions are quite important, which is related to the stability and quality of this substance. According to the concept of "Tiangong Kaiwu", material storage needs to fit its characteristics to ensure its quality.
First word packaging. When using a container with good sealing performance, such as a glass bottle or a specific plastic bottle. Because 2-fluoro-3-chloro-5-bromopyridine is easy to react with water vapor and oxygen in the air, sealed packaging can avoid this danger. If using glass bottles, make sure that the bottle body is intact and the bottle cap is tight; plastic bottles should be chemically resistant to prevent materials and packaging materials from interacting.
Secondary environment. It should be stored in a cool place, and the temperature should not exceed 30 ° C. High temperature can easily cause the molecular activity of this compound to increase greatly, triggering reactions such as decomposition and polymerization, which will damage its purity and structure. And it should be placed in a dry place to avoid water vapor. Adverse reactions such as water vapor or hydrolysis can deteriorate the material. Therefore, the storage place should have good ventilation and dehumidification equipment.
Furthermore, it should be kept away from fire sources and oxidants. 2-Fluoro-3-chloro-5-bromopyridine may be flammable and dangerous in case of fire; oxidants can also react violently with it, causing safety accidents. The storage area should be clearly marked with a no-fire sign, and the oxidizing agent should be placed separately from the compound, and the spacing should be large.
In addition, the storage place should be clearly marked, and the name, specification, and storage date of the compound should be recorded in detail. This is convenient for management and access, and can be used first on the date to avoid long-term storage and deterioration of materials.
In short, the storage of 2-fluoro-3-chloro-5-bromopyridine requires efforts in packaging, environment, prevention of ignition sources and oxidizing agents, and label management to ensure the stability and safety of this substance for subsequent use.