2-Fluoro-3-Bromopyridine

2-Fluoro-3-bromopyridine is a crucial compound in the field of organic synthesis. Its main uses are wide, involving many aspects of medicine, pesticides and material science.
In the field of medicine, 2-fluoro-3-bromopyridine is often a key intermediate in the synthesis of new drugs. Due to its unique chemical structure, it can participate in many chemical reactions to construct molecular structures with specific biological activities. For example, in the synthesis of many antibacterial and antiviral drugs, it is often used as a starting material. Through ingenious chemical reactions, complex drug molecular skeletons are gradually constructed, thus endowing drugs with unique pharmacological activities to deal with various diseases.
In the field of pesticides, this compound also plays a pivotal role. It can be used to create high-efficiency, low-toxicity and environmentally friendly new pesticides. With its special chemical properties, combined with other organic compounds, it can synthesize pesticide components with high selectivity and strong lethality to pests, while reducing the harm to the environment and non-target organisms, providing strong support for the sustainable development of agriculture.
As for the field of materials science, 2-fluoro-3-bromopyridine can be used as an important raw material for the synthesis of special functional materials. After specific polymerization or modification methods, it is introduced into polymer materials, endowing the materials with unique physical and chemical properties such as photoelectric properties and thermal stability, and then expanding the application range of materials in electronic devices, optical materials and other fields.
In summary, 2-fluoro-3-bromopyridine has shown great application potential in many important fields due to its unique chemical structure and reactivity, and plays an indispensable role in promoting technological progress and industrial development in related fields.

2-Fluoro-3-bromopyridine is an organic compound with unique physical properties. It is liquid at room temperature, clear and transparent in appearance, and has a special odor. However, this odor is difficult to describe accurately, and your mileage may vary. The boiling point is about 170-180 ° C. This property is crucial for separation and purification. Controlling the appropriate temperature can effectively separate it from the mixture. The melting point is around -20 ° C, indicating that it will solidify at low temperatures.
2-fluoro-3-bromopyridine has a higher density than water, about 1.7g/cm ³. If mixed with water, it will sink to the bottom of the water. Its solubility is also a key physical property. It is slightly soluble in water, but it can be better dissolved in organic solvents such as ethanol, ether, and dichloromethane. This is due to the presence of pyridine rings and fluorine and bromine atoms in the molecular structure of the compound, resulting in weak forces between it and water molecules, but strong forces with organic solvent molecules.
In addition, 2-fluoro-3-bromopyridine also has a certain volatility, which will gradually evaporate into the air in an open environment. Although its vapor pressure is not high at room temperature, it will increase significantly with the increase of temperature. This volatility needs to be paid special attention during storage and use to ensure that the environment is well ventilated to prevent the accumulation of steam from causing danger. These physical properties have a profound impact on their applications in organic synthesis, drug development, and other fields, providing an important basis for related chemical reactions and process operations.

The chemical synthesis methods of 2-fluoro-3-bromopyridine have been used in ancient times, and there are various methods, each with its own ingenuity.
First, it can be prepared from pyridine and prepared by halogenation reaction. First, a suitable halogenated reagent, such as bromine and pyridine, is reacted under specific conditions, and a bromine atom is introduced into the third position of the pyridine ring. This reaction requires factors such as temperature, reaction time, and the proportion of reactants. If the temperature is too high, side reactions may occur, resulting in impure products; if the time is too short, the reaction is not fully functional, and the yield is not good. After the bromination is completed, the fluorination step is carried out. A suitable fluorination reagent can be selected, and the fluorine atom is introduced into the second position under appropriate solvents and conditions. In this process, the polarity of the solvent and the pH of the reaction system all have a great influence on the reaction process and results.
Second, the target molecule is constructed by multi-step reaction with nitrogen-containing heterocyclic compounds as starting materials. For example, select a nitrogen-containing heterocyclic ring with a specific structure, and first functionalize it to make it have a suitable activity check point. Subsequently, fluorine atoms and bromine atoms are gradually introduced through a series of reactions such as halogenation and substitution, and their positions on the pyridine ring are precisely controlled. This route requires fine regulation of the reaction conditions at each step to ensure the smooth progress of the reaction to achieve high yield and purity.
Third, the coupling reaction catalyzed by transition metals is used to synthesize. Halogenated pyridine derivatives are used as substrates to couple with fluorine and bromine-containing reagents under the action of transition metal catalysts. The choice of transition metal catalysts is crucial, and different metals and their ligands have a significant impact on the activity and selectivity of the reaction. At the same time, the type and amount of additives in the reaction, the reaction medium and other factors need to be carefully considered to optimize the reaction conditions to achieve efficient synthesis of 2-fluoro-3-bromopyridine.

2-Fluoro-3-bromopyridine is also an organic compound. During storage and transportation, many matters need to be paid attention to.
When storing, the first environment. It should be placed in a cool, dry and well-ventilated place. This is because the compound is quite sensitive to temperature and humidity, and high temperature and humid environment can easily cause its properties to change. If it is exposed to high temperature, it may cause a chemical reaction, which will damage its quality; in case of moisture, or hydrolysis.
Furthermore, the choice of container is crucial. It must be stored in a corrosion-resistant container. Due to the chemical activity of 2-fluoro-3-bromopyridine, ordinary materials or reactions with it, the container is damaged and the compound is also contaminated.
Also, the storage area should be kept away from fire sources, heat sources and oxidants. It is flammable, in case of open flame, hot topic, or risk of combustion; contact with oxidants, or violent reaction, endangering safety.
As for transportation, strict specifications must be followed. The packaging must be strong to ensure that it is not damaged by vibration or collision during transportation. When loading and unloading, operators should exercise caution and wear appropriate protective equipment, such as gloves, goggles, etc., to prevent contact injury.
Transportation vehicles also need to be properly selected and do not mix with contraindicated substances. During driving, pay close attention to the condition of the vehicle and the condition of the goods, avoid high temperature and strong light sections, and drive slowly and steadily to ensure safe transportation. In this way, it is necessary to be comprehensive, avoid accidents, and protect the quality and transportation safety of 2-fluoro-3-bromopyridine.

2-Fluoro-3-bromopyridine, as well as organic compounds, is widely used in chemical, pharmaceutical and other fields. However, its market price range often varies due to various factors, making it difficult to determine.
First, the difficulty of preparation is a key factor. The synthesis of this compound may require delicate steps and special reagents. If the synthesis process is complicated, the technical requirements are strict, and the raw materials are rare and the reaction conditions are difficult, the production cost will be high, and its market price will also rise.
Second, the market supply and demand situation has a great impact. If there is a surge in demand for 2-fluoro-3-bromopyridine in fields such as pharmaceutical research and development, and the supply is difficult to increase rapidly, the price will rise; on the contrary, if the demand is sluggish and the supply is excessive, the price will be under downward pressure.
Third, the differences in manufacturers also play a role. Different manufacturers have different production costs and different selling prices due to different technical levels, economies of scale, and management capabilities. Large manufacturers may be able to sell at relatively low prices due to their scale advantages; while small manufacturers may have higher prices due to cost constraints.
Looking at the market in the past, the price of 2-fluoro-3-bromopyridine per kilogram may range from hundreds to thousands of yuan. However, this is only a rough estimate. The current exact price requires detailed consultation with chemical raw material suppliers, chemical trading platforms, or in relevant industry exhibitions in order to obtain an accurate price range to meet actual needs.