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What is the chemical structure of 2- (Ethylsulfonyl) imidazo [1,2a] pyridine-3-Sulfonamide
Alas! To know the chemical structure of 2 - (ethylsulfonyl) imidazolo [1,2 - a] pyridine-3 - sulfonamide, it should be analyzed by chemical method. This compound consists of imidazolo [1,2 - a] pyridine as the base, its 2-position is connected to ethylsulfonyl, and its 3-position is connected to sulfonamide.
Looking at its imidazolo [1,2 - a] pyridine part, the imidazole ring is fused with the pyridine ring, which has a unique conjugated structure, endowing the molecule with a specific electron cloud distribution and chemical activity. The 2-position ethyl sulfonyl group, - SO 2O CH 2O CH < unk >, the sulfur atom in the sulfonyl group is connected to two oxygen atoms by a double bond, which is strongly electron-absorbing, and the ethyl group is the power supplier group, which is connected to the two, affecting the polarity and reactivity of the molecule. The 3-position sulfonamide group, - SO 2O NH < unk >, is connected to the amino group, and the amino group has a certain electron-giving ability. However, the strong electron-absorbing effect of the sulfonyl group makes this part also have special chemical properties.
In general, the chemical structure of 2 - (ethylsulfonyl) imidazolo [1,2 - a] pyridine-3 - sulfonamide is composed of fused heterocycles and specific substituents. The interaction of each part determines the physical and chemical properties of the compound, and it may have specific uses and reactivity in the fields of organic synthesis, medicinal chemistry, etc.
What are the main uses of 2- (Ethylsulfonyl) imidazo [1,2a] pyridine-3-Sulfonamide
2-%28Ethylsulfonyl%29imidazo%5B1%2C2a%5Dpyridine-3-Sulfonamide, namely 2- (ethylsulfonyl) imidazolo [1,2-a] pyridine-3-sulfonamide, this substance has a wide range of uses.
In the field of pharmaceutical research and development, it has significant utility. Due to its unique chemical structure and characteristics, it may exhibit specific biological activities. It can be used as a potential lead compound for researchers to explore in depth, and it is expected to develop new therapeutic drugs after modification and optimization. For example, it targets specific disease-related targets, or has inhibitory or regulatory effects, helping to overcome difficult diseases and contributing to human health and well-being.
In the field of chemical synthesis, it also plays an important role. It can act as a key intermediate for the synthesis of compounds with more complex structures and more specific functions. With its reactivity and structural characteristics, it can participate in a variety of organic synthesis reactions, expand the variety of chemical products, enrich the chemical synthesis path, and promote technological innovation and product upgrading in the chemical industry.
In the field of materials science, there is also potential application value. If it is introduced into a specific material system, it may endow materials with unique properties, such as improving material stability, enhancing material conductivity, etc., so as to meet the needs of special materials in different fields and inject new vitality into the development of materials science.
In short, 2- (ethylsulfonyl) imidazolo [1,2-a] pyridine-3-sulfonamide has important uses in many fields such as medicine, chemical industry, and materials, providing new opportunities and possibilities for the development of various fields.
What are the physical properties of 2- (Ethylsulfonyl) imidazo [1,2a] pyridine-3-Sulfonamide
2-%28Ethylsulfonyl%29imidazo%5B1%2C2a%5Dpyridine-3-Sulfonamide, the Chinese name or 2 - (ethylsulfonyl) imidazolo [1,2 - a] pyridine-3 - sulfonamide. The physical properties of this substance are related to its external characterization and basic physical properties. Let me tell you in detail.
Looking at its morphology, under room temperature and pressure, it may be in the form of white to white solid powder. This morphology is easy to store and use, and also reflects the characteristics of its intermolecular interactions, which makes it exist in this aggregated state under normal conditions.
When it comes to melting point, this substance has a specific melting point value, but the exact value needs to be determined by professional experiments. Melting point is an inherent property of the substance and is closely related to the molecular structure. The strength of the intermolecular force determines the energy required for melting, that is, the melting point. The atoms in the molecule of this compound are connected by specific chemical bonds to form a specific spatial structure, and the interaction between each atom and the group comprehensively determines the melting point.
In terms of solubility, it may have a certain solubility in common organic solvents, such as methanol, ethanol and other alcoholic solvents. Because alcoholic solvents are polar, they can form interactions with some polar groups of the compound, such as hydrogen bonds, to promote their dissolution. In non-polar solvents, such as n-hexane and cyclohexane, the solubility may be very small. Due to the weak interaction between non-polar solvents and the polar part of the compound, it is difficult to overcome the intermolecular force of the compound to disperse in the solvent.
In addition, its density is also an important physical property. Although the exact density data needs to be accurately measured experimentally, it can be inferred from its structure and similar compounds. Generally speaking, due to the relatively large atomic mass elements such as sulfur and nitrogen in the molecule, and the specific molecular configuration, its density may be higher than that of common hydrocarbon compounds.
The physical properties of this substance are closely related to its molecular structure. The structure determines the properties, and the properties reflect the structural characteristics, which is the wonder of chemical substances.
What is the synthesis method of 2- (Ethylsulfonyl) imidazo [1,2a] pyridine-3-Sulfonamide
2-%28Ethylsulfonyl%29imidazo%5B1%2C2a%5Dpyridine-3-Sulfonamide is 2- (ethylsulfonyl) imidazolo [1,2-a] pyridine-3-sulfonamide, and the synthesis method is as follows:
The starting material can be selected from suitable pyridine derivatives and sulfur-containing reagents. First, the pyridine derivative is nucleophilic substitution with a specific halogenated alkane in the presence of a suitable base and solvent, and the ethylsulfonyl moiety is introduced. In this step, the base can be selected from potassium carbonate, etc., and the solvent such as N, N-dimethylformamide (DMF) is reacted at a suitable temperature for a certain period of time, so that the specific position on the pyridine ring is successfully connected to the ethylsulfonyl group.
Then, the structure of imidazolo [1,2-a] pyridine is further constructed for the pyridine ring. Usually, the activity check point on the pyridine ring can be used to form the imidazolo [1,2-a] pyridine ring by cyclization reaction with reagents containing appropriate functional groups, such as compounds containing amino groups and aldehyde groups, under the catalysis of acids or bases. The reaction process needs to control the reaction conditions, including temperature, pH and reaction time, to ensure the smooth progress of the cyclization reaction and good selectivity.
Finally, a sulfonamide group is introduced into the constructed imidazolo [1,2-a] pyridine structure. Sulfonyl chloride can be used to react with ammonia or amine compounds under basic conditions, which help to promote the reaction to form the target product 2- (ethylsulfonyl) imidazolo [1,2-a] pyridine-3-sulfonamide.
The whole synthesis process needs to be finely regulated for each step of the reaction conditions, and after each step of the reaction, suitable separation and purification means, such as column chromatography, recrystallization, etc. are required to ensure the purity of the intermediate product and the final product, so that 2- (ethylsulfonyl) imidazolo [1,2-a] pyridine-3-sulfonamide can be synthesized efficiently and with high quality.
2- (Ethylsulfonyl) imidazo [1,2a] pyridine-3-Sulfonamide What are the precautions during use
2-%28Ethylsulfonyl%29imidazo%5B1%2C2a%5Dpyridine-3-Sulfonamide is a special chemical substance, and many things need to be paid special attention during use.
First, safety protection is very important. This chemical may have certain toxicity and irritation, and it is necessary to take comprehensive protective measures when coming into contact. Wear protective clothing to ensure that all parts of the body are protected to avoid skin contact with it, causing allergies or other damage. Wear protective gloves and choose the right material to closely isolate the substance. At the same time, wear goggles to prevent it from accidentally splashing into the eyes and causing serious damage to the eyes.
Second, the operating specifications should not be underestimated. It should be operated in a well-ventilated environment to ensure smooth indoor air circulation and timely discharge of harmful gases that may be generated to avoid their accumulation in the air and endanger human health. Use precise instruments and equipment, operate strictly according to the specified process, weighing, mixing and other steps must be accurate and not sloppy in the slightest, otherwise it may affect the experimental results and may also cause danger.
Third, storage conditions must be strictly controlled. It needs to be stored in a dry place to prevent moisture, because it may react with moisture and change chemical properties. At the same time, it should be placed in a cool place, away from heat and fire sources. This substance may be flammable, and high temperature environments can easily cause serious accidents such as fires. And it should be stored separately from other chemical substances to avoid interaction and unpredictable chemical reactions.
Fourth, waste disposal needs to be compliant. Waste after use must not be discarded at will. It should be properly disposed of in accordance with relevant environmental protection regulations, or handed over to professional institutions for recycling and disposal to prevent pollution to the environment and endanger ecological balance. Only by treating the above things with caution can 2-%28Ethylsulfonyl%29imidazo%5B1%2C2a%5Dpyridine-3-Sulfonamide be used safely and effectively.