2-(ethylsulfanyl)pyridine-4-carboxamide

2-%28ethylsulfanyl%29pyridine-4-carboxamide, Chinese name or 2 - (ethylthio) pyridine-4 - formamide. This substance is widely used in the field of medicinal chemistry, and is often used as a key intermediate to synthesize compounds with specific biological activities. Pharmaceutical developers hope to use its unique chemical structure to create new drugs, such as inhibitors or regulators targeting specific disease targets.
In the field of materials science, it may be able to participate in the preparation of functional materials. For example, after a specific chemical reaction, it can be introduced into a polymer to impart special properties such as fluorescence and adsorption to the material, so that it can be used in sensors, separation materials and other fields.
In terms of pesticide chemistry, 2 - (ethylthio) pyridine-4 - formamide may be used as a lead compound. After structural modification and optimization, high-efficiency, low-toxicity and environmentally friendly pesticide products have been developed for the control of crop diseases and pests, so as to ensure the harvest of agricultural production. In short, due to its structural characteristics, it has shown potential application value in many scientific research and industrial fields, providing new opportunities and directions for the development of various fields.

2-% (ethylsulfanyl) pyridine-4-carboxamide, that is, 2 - (ethylthio) pyridine - 4 - formamide, the synthesis method is as follows:
The starting material can be selected from 2 - chloropyridine - 4 - formamide and sodium ethanethiol. In the reactor, 2 - chloropyridine - 4 - formamide is dissolved in a suitable organic solvent such as N, N - dimethylformamide (DMF) in a certain proportion. This solvent is mild in nature, has good solubility to the reaction substrate, and does not easily interfere with the reaction process. After stirring evenly, slowly add sodium ethanethiol. This process requires strict control of the reaction temperature, preferably 30-50 ° C. Too high temperature can easily lead to side reactions, and too low will cause the reaction rate to be too slow.
During the reaction, ethyl thio negative ions in sodium ethyl mercaptan attack the carbon atoms attached to the chlorine atoms in 2-chloropyridine-4-formamide, and a nucleophilic substitution reaction occurs. As the reaction proceeds, the chlorine atoms are replaced by ethyl thio to form the target product 2 - (ethyl thio) pyridine-4-formamide. The reaction time is about 3-5 hours, and continuous stirring is required during this period to ensure that the reactants are fully contacted and the reaction is more complete.
After the reaction is completed, an appropriate amount of water is added to the reaction system, and the product is precipitated due to its low solubility in water. Then the solid product is separated by filtration operation. Then it is washed with an appropriate amount of water and an organic solvent in sequence to remove residual impurities. Finally, after vacuum drying treatment, a pure 2 - (ethylthio) pyridine-4 - formamide solid product can be obtained.
Another synthesis strategy is to use 2 - hydroxypyridine-4 - formamide as the starting material. It is first reacted with p-toluenesulfonyl chloride to generate the corresponding p-toluenesulfonate derivative. The hydroxyl group in this derivative is replaced by p-toluenesulfonyl oxide, and the activity is enhanced. Then, the derivative is reacted with ethanethiol under alkaline conditions, and potassium carbonate can be selected as the base. The reaction is carried out in an organic solvent such as acetonitrile, and the temperature is controlled at 50-70 ° C. Ethanethiol forms ethanethiol negative ions in an alkaline environment, attacks p-toluenesulfonate derivatives, and realizes nucleophilic substitution. 2 - (ethylthio) pyridine-4-formamide can also be prepared. The subsequent separation and purification steps are similar to those described above, and the pure product can be obtained through extraction, washing, drying and other operations.

2-%28ethylsulfanyl%29pyridine-4-carboxamide is 2- (ethylthio) pyridine-4-formamide. This is an organic compound. Its physical and chemical properties are unique and it is very critical in the fields of chemical industry and medicine.
Looking at its physical properties, under room temperature, 2- (ethylthio) pyridine-4-formamide is mostly solid due to strong intermolecular forces. However, its exact appearance, such as color and crystal form, may vary depending on the preparation method and purity. Its melting point and boiling point are of great significance to chemical production. The melting point is related to the temperature at which a substance changes from solid to liquid state, and the boiling point determines the conditions for liquid to gaseous state. These two help to separate and purify this compound. And the substance may have some solubility in common organic solvents such as ethanol and acetone, which is conducive to its dispersion in the reaction system and makes the reaction easier to proceed.
When it comes to chemical properties, the pyridine ring of 2- (ethylthio) pyridine-4-formamide is reactive with the amide group. The nitrogen atom of the pyridine ring is rich in electrons and can be used as a nucleophilic reagent to participate in the reaction. For example, nucleophilic substitution occurs with halogenated hydrocarbons, new functional groups are introduced, and the application of the compound is expanded. The amide group can be hydrolyzed. Under acidic or basic conditions, the amide bond is broken to form the corresponding carboxylic acid or carboxylate and amine. This reaction is often used in organic synthesis to prepare compounds containing carbox At the same time, ethylthio also has unique reactivity, which can oxidize to form sulfoxide or sulfone compounds, change the polarity and biological activity of the compounds, and may optimize the properties of drugs in pharmaceutical research and development. In short, the physicochemical properties of 2 - (ethylthio) pyridine-4 - formamide lay the foundation for its application in many fields.

What you are asking is the price of 2 - (ethylthio) pyridine-4 - formamide in the market. However, the price of this chemical often changes for many reasons, which is difficult to determine.
First, the cost of producing this chemical affects its price. The difficulty of obtaining raw materials, the price of high and low, and the equipment and energy required for the production process are all cost factors. If raw materials are scarce and difficult to find, or the production process is complicated, the cost will be high, and the price will also rise.
Second, the market supply and demand situation, the price is very huge. If the market demand for this product is strong and the supply is limited, the price will rise; conversely, if the supply exceeds the demand, the price will decline.
Third, the brand and quality also have an impact. Well-known brands and high-quality products are often more expensive. Because of their stricter production control and quality inspection, product stability and purity are better.
Fourth, the purchase quantity is different, and the price is also different. Bulk purchases, due to scale effects, the unit price can often be more favorable.
To know the exact price of this product, you can consult chemical product suppliers, distributors, or consult chemical product trading platforms, so that you can get more accurate price information.

2-%28ethylsulfanyl%29pyridine-4-carboxamide, that is, 2 - (ethylthio) pyridine-4 -formamide, this is an organic compound. In terms of safety and toxicity, there is no detailed book detailing its characteristics, but it can be inferred from its structure and similar compounds.
Looking at its structure, it contains a pyridine ring and an amide group. Pyridine compounds are mostly toxic, or irritate the eyes, skin and respiratory tract. For example, common pyridine can cause eye and respiratory irritation, and inhalation of high concentrations can cause dizziness, nausea, vomiting, etc. Amide compounds vary greatly in toxicity, some are biologically active, or non-toxic when appropriate, but some may be potentially harmful due to the production of toxic intermediates in the metabolic process.
2 - (ethylthio) pyridine-4-formamide ethylthio, containing sulfur atoms, some sulfur-containing organic compounds or have a special odor, and some are toxic. Such as ethanethiol, it has a strong odor, and high concentrations can cause headache, nausea and anesthesia.
Due to the lack of exact experimental data, it can only be speculated that 2 - (ethylthio) pyridine-4-formamide may have certain toxicity and irritation to organisms. When handling this substance, it is necessary to follow the safe operation practices of chemicals, work in good ventilation, and wear suitable protective equipment, such as gloves, goggles, and gas masks, to prevent contact and inhalation. In case of inadvertent contact, rinse with plenty of water immediately and seek medical attention immediately.