2-(Ethoxycarbonyl)pyridine

2-%28Ethoxycarbonyl%29pyridine is 2 - (ethoxycarbonyl) pyridine, which has a wide range of uses.
In the field of organic synthesis, it can be used as a key intermediate. With the unique chemical properties of ethoxycarbonyl and pyridine rings, it can participate in various reactions, such as nucleophilic substitution and electrophilic substitution. Through nucleophilic substitution reactions, ethoxycarbonyl ester groups can interact with many nucleophilic reagents to generate new compounds, which are very effective in building complex organic molecular structures.
In the field of pharmaceutical chemistry, the structure of 2 - (ethoxycarbonyl) pyridine can be integrated into the design of drug molecules. Pyridine rings are commonly found in many pharmaceutical active ingredients because of their good biological activity and coordination ability. Ethoxycarbonyl can regulate the lipophilicity, stability and metabolic properties of molecules, so drugs with better pharmacological activity and pharmacokinetic properties can be developed based on this.
In materials science, 2- (ethoxycarbonyl) pyridine can be used to prepare functional materials. After a specific chemical reaction, it is introduced into the structure of a polymer, which can endow the material with special physical and chemical properties, such as improving the solubility, thermal stability or optical properties of the material, so as to meet the specific needs of materials in different fields.
Overall, 2 - (ethoxycarbonyl) pyridine has important uses in organic synthesis, drug development, and materials science, providing a key material foundation and research direction for the development of related fields.

2-%28Ethoxycarbonyl%29pyridine, that is, 2 - (ethoxycarbonyl) pyridine, is one of the organic compounds. Its physical properties are as follows:
Under normal temperature and pressure, this substance is mostly colorless to light yellow liquid. Visually, the texture is uniform and clear, like a calm liquid, without visible impurities or suspended solids, and the luster is soft, just like a gift of nature, warm and moist without losing its characteristics. < Br >
Smell its smell, with a special aromatic smell. This smell is neither rich and pungent, nor light and tasteless, but unique, like outlining a unique olfactory profile in the air. However, its smell is lighter, and it needs to be sniffed carefully to detect it. It seems to be random, showing its unique charm.
When it comes to boiling point, it is about 230-235 ° C. When it is heated, the temperature gradually rises. At this point, the intermolecular force is broken, and the substance slowly changes from liquid to gaseous state, like a gorgeous transformation, showing its unique physical changes on a specific temperature stage.
Looking at its melting point, it is about -20 ° C. When the temperature decreases to this point, the molecular movement gradually slows down, and the arrangement between them becomes more orderly. It transforms from a disordered liquid state to an ordered solid state, just like the magic brush of nature. With a flick of the brush, it gives it a completely different shape.
Its density is about 1.10 - 1.12 g/cm ³, which shows that under the same volume conditions, 2 - (ethoxycarbonyl) pyridine is denser than water. If it is placed in the same container as water, it can be seen that it sinks to the bottom of the water, like a pearl hidden in the bottom of the water, showing its unique density characteristics.
Furthermore, its solubility is quite interesting. This substance is slightly soluble in water, just like a shy visitor. Its affinity with water is limited, so it is willing to stay for a while and integrate a little. However, it is soluble in common organic solvents, such as ethanol, ether, chloroform, etc. It is like finding like-minded friends, and it can be intimately integrated with them. It shows good solubility in the arms of organic solvents.
The above physical properties constitute the unique "physical portrait" of 2 - (ethoxycarbonyl) pyridine, laying a solid foundation for its application in many fields such as organic synthesis and medicinal chemistry.

To prepare 2 - (ethoxycarbonyl) pyridine, the following method can be followed.
First, pyridine is taken as the starting material, and it reacts with diethyl oxalate under the catalysis of strong bases such as sodium metal or sodium alcohol. The nitrogen atom of pyridine is basic and can interact with the strong base, which changes the electron cloud distribution of the pyridine ring, which is more conducive to the nucleophilic substitution reaction.
In this reaction, the carbonyl carbon of diethyl oxalate is electrophilic, and the carbon atom at a specific position (2-position) on the pyridine ring is nucleophilic, and the nucleophilic substitution reaction occurs between the two. The role of a strong base is to take away the active hydrogen in diethyl oxalate to form a carboanion. This carboanion attacks the 2-position of the pyridine ring, and then goes through a series of rearrangement and elimination steps to generate the intermediate of 2- (ethoxycarbonyl) pyridine.
When reacting, the reaction temperature, the proportion of reactants, and the reaction time need to be strictly controlled. If the temperature is too low, the reaction rate is slow, and it is difficult to obtain enough products; if the temperature is too high, it may trigger side reactions and reduce the purity of the product. Improper proportions of reactants can also lead to incomplete reactions or excessive by-products.
After the reaction is completed, the target product can be separated from the reaction mixture by separation and purification methods such as distillation, extraction, and column chromatography to obtain pure 2- (ethoxycarbonyl) pyridine.
Distillation method can separate the product from low-boiling or high-boiling impurities according to the difference in the boiling point of each substance; extraction uses the different solubility of the target product and impurities in different solvents to achieve preliminary separation; column chromatography uses the difference in the adsorption capacity of the adsorbent to different substances to further purify the product.
Through the above steps and careful operation, 2- (ethoxycarbonyl) pyridine can be obtained.

2-%28Ethoxycarbonyl%29pyridine, that is, 2 - (ethoxycarbonyl) pyridine, this substance should be paid attention to when storing and transporting.
Safety is the first priority. Because it may have certain toxicity and irritation, contact can cause skin, eye and respiratory discomfort. Therefore, when operating, it is necessary to wear suitable protective equipment, such as protective gloves, goggles and gas masks, to prevent contact and inhalation.
The second is the storage environment. It should be stored in a cool, dry and well-ventilated place, away from fire, heat sources, and direct sunlight. Because it is sensitive to heat and light, high temperature and light may cause decomposition or deterioration. At the same time, it needs to be stored separately from oxidants, acids, alkalis, etc., and should not be mixed with storage to avoid chemical reactions.
Furthermore, it is related to transportation. During transportation, it is necessary to ensure that the container does not leak, collapse, fall or damage. The tank (tank) car used during transportation should have a grounding chain, and holes can be set in the tank to baffle to reduce shock and generate static electricity. It is strictly forbidden to mix and transport with oxidants, acids, alkalis, etc. During transportation, it should be protected from exposure to the sun, rain and high temperature.
In addition, the storage and transportation places should be equipped with suitable materials to contain leaks. Once leaks occur, they can be dealt with in time to reduce hazards. And the relevant operation and management personnel need professional training to be familiar with the characteristics, hazards and emergency treatment methods of 2 - (ethoxycarbonyl) pyridine, so as to ensure the safety of personnel and material integrity to the greatest extent during storage and transportation.

2-%28Ethoxycarbonyl%29pyridine is 2 - (ethoxycarbonyl) pyridine, the market price range of this product is difficult to determine. The price often varies due to many factors, such as material source, preparation process, market supply and demand, quality specifications, and even the time of transaction.
Looking at the market conditions of the past, when the chemical raw material market is stable, if the quality is ordinary and the quantity is considerable, the price of 2 - (ethoxycarbonyl) pyridine per kilogram may be in the domain of several hundred yuan. If its quality is high, and it meets the high standards required for fine chemical and pharmaceutical research and development, the price will rise sharply, or to several thousand yuan per kilogram.
And the supply and demand of the market, the impact is particularly serious. If there is a sudden surge in demand and a shortage of supply, the price will be high; on the contrary, the supply will exceed the demand, and the price may fall. In addition, the preparation processes taken by different suppliers are different, and the costs are different, resulting in differences in selling prices. To know the exact price, when at a specific time, consult each supplier in detail and make a comprehensive comparison to obtain a more accurate price.