2-Ethoxy-5-pyridineboronicacid

2-Ethoxy-5-pyridyl boronic acid is widely used in the field of organic synthesis. It is crucial in carbon-carbon bond formation reactions, such as the Suzuki-Miyaura coupling reaction. In this reaction, the boric acid can efficiently form biaryl, alkenyl aryl and other carbon-carbon bond compounds with organic halides or pseudo-halides in the presence of palladium catalysts and bases, and has many applications in pharmaceutical chemistry, materials science and other fields.
In the process of drug research and development, with the help of Suzuki-Miyapura coupling reaction, 2-ethoxy-5-pyridyl boronic acid can be used as raw material to build a complex drug molecular skeleton and help create new drugs. This strategy is used in the synthesis of many anti-cancer and antiviral drugs.
In the field of materials science, the boric acid also plays a key role. When synthesizing organic materials with specific photoelectric properties, the coupling reaction it participates in can precisely regulate the molecular structure and properties, and prepare materials such as Light Emitting Diode and organic solar cells.
In addition, in the field of total synthesis of natural products, 2-ethoxy-5-pyridyl boronic acid provides a powerful means for the synthesis of complex natural products. Through its reaction with other organic reagents, the complex structure of natural products can be gradually constructed, and the biological activity and mechanism of action of natural products can be explored.

The synthesis method of 2-ethoxy-5-pyridyl boronic acid follows the classic path of organic synthesis. The common one is to use the halogenate containing the pyridine structure as the starting material, react with organometallic reagents such as borate esters, catalyzed by transition metals such as palladium, and follow the principle of Suzuki-Miyaura coupling reaction. This reaction condition needs to be carefully regulated, and the amount of palladium catalyst, reaction temperature, type and amount of base are all related to the reaction effect. Usually, in an inert environment such as toluene and dioxane, nitrogen is introduced to protect and maintain a moderate temperature (usually 60-100 ° C). After a few years, halogenated pyridine can be coupled with borate esters, and then the target product 2-ethoxy-5-pyridyl boronic acid can be formed.
Furthermore, the pyridine ring structure can be constructed first, and then ethoxy and borate groups can be introduced. For example, using a suitable pyridine derivative as a substrate, ethoxy groups are introduced by nucleophilic substitution reaction, and then boric acid groups are introduced at specific positions in the pyridine ring through metallization-boronation strategies. In this step, a strong base such as butyl lithium is commonly used in the metallization step. The hydrogen on the pyridine ring is replaced by lithium at low temperature, and then reacts with the borate ester reagent to successfully construct the boric acid group. This path requires strict control of the reaction conditions, especially the low temperature operation and the stability of the reaction intermediates. A little carelessness can easily lead to side reactions, which affect the purity and yield of the product.
Or, pyridine-5-boric acid is used as the starting material and ethoxy is introduced through etherification reaction. This process requires the selection of a suitable etherification reagent, such as halogenated ethane, and the nucleophilic substitution reaction is carried out under the catalysis of base. Potassium carbonate, sodium carbonate, etc. can be used as a base to react in polar solvents such as N, N-dimethylformamide (DMF), and the reaction temperature and time can be controlled to obtain 2-ethoxy-5-pyridyl boronic acid. However, this method should pay attention to the stability of pyridyl-5-boronic acid itself and possible side reactions during the reaction, such as decomposition of boric acid groups or substitution of other positions.

2-Ethoxy-5-pyridyl boronic acid, an organic compound. Its physical and chemical properties are unique and relevant to its application in many fields.
Looking at its physical properties, 2-ethoxy-5-pyridyl boronic acid often takes a solid form at room temperature and pressure, but the specific properties are also affected by the preparation process and purity, either crystalline or powdery. Its melting point is a key physical parameter. The specific melting point reflects the intermolecular forces and crystal structure characteristics, which is very beneficial for identification and purity judgment. The exact melting point value is not yet known.
Solubility is also an important physical property. In organic solvents, such as common ethanol, ether, etc., it may have a certain solubility. Due to the structure of ethoxy and pyridine rings in the molecule, the molecule has moderate organic solubility; solubility in water may be limited. Although the caustic acid group has a certain hydrophilicity, the hydrophobicity of ethoxy and pyridine rings may weaken the overall water solubility.
As for chemical properties, boric acid groups give it unique chemical activity. It can participate in many organic reactions, such as the Suzuki-Miyaura reaction, in which boric acid groups are coupled with halogenated aromatics or olefins under palladium catalysis to form carbon-carbon bonds. It is of great significance for the preparation of complex pyridine derivatives in organic synthesis, and is a key reaction step in the field of creating drugs and materials.
and the pyridine ring of 2-ethoxy-5-pyridine boronic acid is also reactive. The nitrogen atom on the ring can participate in nucleophilic and electrophilic reactions, interact with various reagents, and derive a variety of pyridine compounds, enriching the organic synthesis path. Due to its unique structure and activity, it is widely used in the field of organic synthetic chemistry and is an important intermediate for the preparation of many functional materials and bioactive molecules.

2-Ethoxy-5-pyridyl boronic acid is in the market, and its price range is difficult to determine. Its price is determined by many factors, such as the purity of quality, the amount of production, the urgency of demand, and the smooth supply.
In the past, the price of chemical materials on the market often changed over time. If the quality is good and refined, the price may be high; if the mass production is rich, the supply will exceed the demand, and the price will decline; on the contrary, if the supply is thin, the price will rise.
In the world of "Tiangong Kaiwu", although there is no such chemical fine material, it is the same. The price of materials is not separated from the supply and demand ends. If you want to know the exact price of 2-ethoxy-5-pyridyl boronic acid today, you should consult the chemical material supplier or visit the platform of chemical product trading to see the price quoted recently. However, this price is not constant and changes with the market, so you need to pay attention to it in real time.

2-Ethoxy-5-pyridyl boronic acid, this is a reagent commonly used in organic synthesis. Its storage conditions are very critical, related to its stability and quality.
According to the concept of "Tiangong Kaiwu", everything needs to be stored in a suitable place in order to preserve its properties and make the most of it. The storage of this reagent is first at low temperature. It should be stored in a refrigerated environment of 2 to 8 degrees, so that its chemical reaction rate can be reduced and its structure can be maintained. Due to high temperature, molecular movement is intensified, which is easy to decompose or deteriorate.
Furthermore, it needs to be placed in a dry place. This reagent is afraid of water, which can initiate reactions such as hydrolysis, which can damage its purity and activity. Therefore, in the storage place, there should be measures to dehumidify, such as using a desiccant, to avoid moisture.
And keep it sealed. Oxygen, carbon dioxide, etc. in the air can react with it. Sealing can protect its chemical properties from external interference. Store in a well-sealed container and seal it immediately after use. Do not expose it to air for a long time.
When taking it, it should also be quick to avoid long-term contact with air and moisture. Following these storage methods can protect the quality of 2-ethoxy-5-pyridyl boronic acid and play its role in applications such as organic synthesis.