2-Ethoxy-5-bromopyridine

2-Ethoxy-5-bromopyridine is also an organic compound. It has the structural characteristics of halogenated pyridine and ether, which give it unique chemical properties.
In the nucleophilic substitution reaction, the bromine atom is active and easy to be replaced by nucleophilic reagents. Due to its electronegativity difference, the carbon-bromine bond is polar, and nucleophilic reagents such as alkoxides and amines can attack this carbon, causing bromine ions to leave and form new carbon-heteroatomic bonds.
Its ethoxy part also participates in the reaction. Because the oxygen atom has lone pairs of electrons, it can be used as a weak nucleophilic reagent or protonated under acidic conditions, which affects the molecular reactivity. In case of strong acid, the oxygen in the ethoxy group can be protonated, causing ether bond fracture, ethanol and pyridine derivatives.
In metal-catalyzed coupling reactions, 2-ethoxy-5-bromopyridine is also a useful substrate. Such as palladium-catalyzed cross-coupling, bromine atoms can be coupled with organoboronic acids, organozinc reagents, etc., to increase molecular complexity, and are used to construct various carbon-carbon and carbon-heteroatom bonds. It has important applications in drug synthesis and materials science.
In addition, its pyridine ring is basic, and the nitrogen atom can accept protons or complex with Lewis acid. This alkalinity can affect the solubility and reactivity of molecules in solution, and can be used to regulate the reaction process and selectivity in organic synthesis. 2-ethoxy-5-bromopyridine presents various chemical properties due to the interaction of bromine atoms, ethoxy groups and pyridine rings in the structure, and is an important building block of organic synthetic chemistry.

2-Ethoxy-5-bromopyridine is a compound commonly used in organic synthesis. The common synthesis methods are as follows.
First, 5-bromo-2-hydroxypyridine is used as the starting material. This compound and ethanol can undergo nucleophilic substitution in the presence of appropriate bases and catalysts. Bases, such as potassium carbonate, can promote the formation of ethoxy negative ions in ethanol, which attack the carbon atoms attached to the hydroxyl group in 5-bromo-2-hydroxypyridine, thereby replacing the hydroxyl group to obtain 2-ethoxy-5-bromopyridine. The reaction is usually carried out under the condition of heating and reflux to accelerate the reaction process and move the reaction in the direction of generating the target product.
Second, 2-chloro-5-bromopyridine is used as the starting material. It reacts with sodium ethanol in a suitable solvent. The ethoxy negative ion in sodium ethanol acts as a nucleophile to attack the carbon atom connected to the chlorine atom in 2-chloro-5-bromopyridine. The chlorine atom leaves, and the target product 2-ethoxy-5-bromopyridine is obtained. The solvents used are mostly polar aprotic solvents, such as N, N-dimethylformamide (DMF), etc. These solvents can dissolve the reactants and help to stabilize the reaction intermediates and promote the smooth progress of the reaction.
Or, using pyridine as the starting material, after bromination, bromine atoms are introduced at the 5th position of the pyridine ring to obtain 5-bromopyridine. After hydroxylation, hydroxyl groups are introduced at the 2nd position to obtain 5-bromopyridine. The subsequent steps are as the first method above, and 2-ethoxy-5-bromopyridine is prepared by reacting with ethanol. Although there are many steps in this synthesis route, the starting material pyridine used is relatively common and easy to obtain, and the reaction conditions of each step are relatively mild, so it is also used in the field of organic synthesis.
There are various methods for synthesizing 2-ethoxy-5-bromopyridine, and researchers can choose the appropriate synthesis path according to the actual situation, such as the availability of raw materials, the difficulty of reaction conditions, cost and other factors.

2-Ethoxy-5-bromopyridine is useful in various fields such as medicinal chemistry and materials science.
In the field of medicinal chemistry, this compound is often a key intermediate for the synthesis of many drug molecules. Due to the specific structure of the pyridine ring with ethoxy and bromine atoms, it is endowed with unique chemical activities and pharmacological properties. Through organic synthesis, its structure can be modified and modified to create drugs with specific biological activities. For example, various functional groups can be introduced by substitution reactions with different nucleophiles to develop antibacterial, anti-inflammatory, anti-tumor and other drugs.
In materials science, 2-ethoxy-5-bromo-pyridine also has outstanding performance. It can participate in the synthesis of organic semiconductor materials. The conjugate structure of the pyridine ring, coupled with the appropriate modification of ethoxy and bromine atoms, may optimize the electronic transport properties and optical properties of the material. Based on this, it is expected to prepare excellent organic Light Emitting Diode (OLED) materials and organic field effect transistor (OFET) materials, which will contribute to the development of display technology and electronic devices.
Furthermore, in the field of organic synthetic chemistry, 2-ethoxy-5-bromopyridine is often used as a reaction substrate to explore new reaction pathways and methodologies. Its unique structure can provide organic chemists with novel reaction check points and reaction modes, help develop efficient and green organic synthesis strategies, and promote the progress of organic synthetic chemistry.
In summary, although 2-ethoxy-5-bromopyridine is an organic compound, it has shown great application potential in many important fields such as medicine, materials, and organic synthesis. It is a key substance that cannot be ignored in chemical research and industrial production.

2-Ethoxy-5-bromopyridine, this is a fine chemical in organic chemistry. Its market price often varies depending on quality, purity, purchase quantity and market supply and demand.
In the past, in books such as "Tiangong Kaiwu", although there was no price of such fine chemicals, according to today's market conditions, if the purity is normal, if purchased in small batches, the price per gram may be in the tens of yuan. If the purity is extremely high, reaching the level of scientific research, the price per gram may rise to more than 100 yuan.
If purchased in large quantities, such as kilograms, due to the scale effect, the unit price may decrease significantly, falling to a few yuan to a few tens of yuan per gram. Moreover, market supply and demand also affect its price. If demand is strong and supply is low, prices will rise; conversely, if supply exceeds demand, prices will decline.
Furthermore, different suppliers have different pricing. Produced by well-known large factories, due to strict quality control, prices may be high; while small factories, prices may be lower. For exact prices, consult chemical product suppliers and refer to real-time market quotations.

2-Ethoxy-5-bromopyridine is also an organic compound. Its storage conditions are crucial and related to the stability and quality of this substance.
This substance should be stored in a cool, dry and well-ventilated place. In a cool place, the temperature should not be too high. If it is too high, it is easy to cause chemical reactions and damage its structure and properties. It is common sense that the temperature should be controlled between 2-8 ° C. This temperature range can ensure the relative stability of its chemical properties.
A dry environment is also indispensable. If this substance encounters water vapor, or triggers reactions such as hydrolysis, it will deteriorate. Therefore, in the storage place, use desiccant and other substances to maintain dryness, so that the air humidity is maintained at a low level. Generally speaking, the relative humidity should be lower than 60%.
Well ventilated to prevent the accumulation of volatile gas. If the volatile gas is concentrated in one place, there may be a risk of explosion, and the second will also affect the quality of the material. In the storage place, good ventilation equipment should be installed to allow air to circulate.
Furthermore, this material should be stored separately from oxidants, acids, bases, etc. Oxidants have strong oxidizing properties, or oxidize with 2-ethoxy-5-bromopyridine; acids and bases, or cause acid-base reactions, can cause them to deteriorate. Therefore, when storing, be sure to store them in categories to avoid mutual influence.
Packaging should not be ignored. Use well-sealed packaging materials, such as glass bottles, plastic bottles, etc., and the packaging materials should be chemically resistant to prevent packaging damage, causing this material to be exposed to the external environment and deteriorate. All of these are important rules for storing 2-ethoxy-5-bromopyridine, and must be followed carefully to ensure its quality and safety.