2-Ethoxy-3-trifluoromethyl-5-aminopyridine

2-Ethoxy-3-trifluoromethyl-5-aminopyridine is an organic compound. It has important applications in chemical synthesis, pharmaceutical research and development, etc.
In chemical synthesis, it is often used as a key intermediate. With its special molecular structure, it can participate in a variety of chemical reactions to build more complex organic molecular structures. For example, it can combine nucleophilic substitution, coupling reaction, etc. with many reagents to synthesize organic materials with specific functions, which are used in the preparation of plastics, rubber, coatings, etc., which is very beneficial for improving material properties.
In the field of pharmaceutical research and development, it is of great significance. Due to its unique chemical properties, or with specific biological activities. Can be used as a lead compound, through structural modification and optimization, to develop new drugs. Or show affinity and inhibition or activation of specific disease targets, such as in anti-tumor, anti-infection, neurological disease treatment, etc., have potential application prospects. By studying its interaction with biomacromolecules, researchers hope to develop innovative drugs with better efficacy and less side effects.
In short, 2-ethoxy-3-trifluoromethyl-5-aminopyridine plays a significant role in the chemical and pharmaceutical fields, providing key support for the development of related industries and promoting the continuous progress of materials science and pharmaceutical science.

The synthesis method of 2-ethoxy-3-trifluoromethyl-5-aminopyridine has always been important in the field of organic synthesis. To obtain this compound, various paths are often followed.
First, it can be started from a pyridine derivative. Choose a suitable pyridine substrate with a modifiable group at a specific position. If starting with a pyridine halide, introduce ethoxy first. With ethanol and alkali agents, such as potassium carbonate, in a suitable solvent, such as N, N-dimethylformamide, heating and stirring, the halogen atom and ethoxy group undergo nucleophilic substitution reaction. This step requires temperature control and reaction time to ensure that the ethoxy group is accurately connected to the designated check point.
Then, trifluoromethyl is introduced. Trifluoromethylation reagents, such as trifluoromethylhalide zinc, are often used in metal catalysts, such as palladium catalysts, to react with pyridine derivatives. This reaction condition is harsh, and the anhydrous and oxygen-free reaction system is required to be quite high. Moreover, factors such as catalyst dosage and reaction temperature have a great impact on the reaction yield and selectivity.
As for the introduction of amino groups, there are many ways. If there are suitable convertible groups on the pyridine ring, such as nitro groups, the nitro groups can be converted into amino groups by reduction by means of iron powder, hydrochloric acid or catalytic hydrogenation. Or by nucleophilic substitution reaction, ammonia or amine reagents can be used to react with pyridine derivatives with suitable leaving groups to introduce amino groups.
Second, strategies for constructing pyridine rings can be considered. The target pyridine compound is synthesized by cyclization reaction from small molecules containing ethoxy groups, trifluoromethyl groups and groups that can be converted into amino groups. If the enamines and nitriles containing the corresponding groups are cyclized and condensed under suitable catalyst and reaction conditions, the pyridine ring is constructed, and then the target product is obtained through subsequent modification. This path requires fine design of the structure and reaction conditions of the starting material to ensure that the construction of the pyridine ring conforms to expectations and the positions of the substituents are correct. During the synthesis process, the reaction needs to be monitored by thin-layer chromatography, nuclear magnetic resonance and other analytical methods according to the reaction process to ensure that the reaction of each step is smooth, and high-purity 2-ethoxy-3-trifluoromethyl-5-aminopyridine is finally obtained.

2-Ethoxy-3-trifluoromethyl-5-aminopyridine, this is an organic compound. Its physical and chemical properties are crucial for its application in many fields.
First, the appearance is usually white to light yellow solid or crystalline powder. This property is very important for observation and preliminary identification, and can be recognized by the naked eye.
In terms of melting point, it has been experimentally determined to be in a specific temperature range. The determination of melting point is like setting a unique temperature label for the compound, which is of great significance for purity identification and related reaction conditions. If the purity is high, the melting point is relatively fixed and sensitive; if it contains impurities, the melting point may be offset and the melting range becomes wider. The boiling point of
is also a key physical property. Under specific pressure conditions, it will boil into a gaseous state at a certain temperature. The value of the boiling point is of great significance for separation and purification operations such as distillation. According to this, the appropriate temperature can be set to achieve effective separation from other substances.
Solubility is also a key consideration. In organic solvents such as ethanol and dichloromethane, it exhibits a certain solubility. This property makes it possible to choose a suitable solvent to build a reaction environment in organic synthesis reactions and promote the smooth progress of the reaction. In water, the solubility is relatively poor, which limits its application in some aqueous systems.
Chemical properties, amino groups give it a certain alkalinity. It can neutralize with acids to form corresponding salts. This reaction can be used in organic synthesis to prepare specific derivatives and expand their chemical uses. At the same time, the presence of ethoxy and trifluoromethyl affects the distribution of molecular electron clouds and changes the reactivity of pyridine rings. Trifluoromethyl has strong electron absorption, which reduces the electron cloud density of pyridine rings and increases the difficulty of electrophilic substitution reactions, but may be conducive to nucleophilic substitution reactions.
2-ethoxy-3-trifluoromethyl-5-aminopyridine has rich and unique physicochemical properties. These properties are intertwined and determine its application direction and value in organic synthesis, medicinal chemistry and other fields.

I think what you are asking is the price range of 2-ethoxy-3-trifluoromethyl-5-aminopyridine in the market. However, the price of this chemical often changes due to multiple reasons, and it is difficult to determine its fixed number.
First, the price varies depending on the supplier. Large merchants supply, or because of the excellent scale, the price is more affordable; small merchants operate, or because of the cost, the price is slightly higher. Second, the amount also affects the price. If the purchase volume is huge, the merchant sells it for promotion, or gives a discount, and the price is reduced; if the purchase volume is small, the merchant's profit is thin, and the price may be the highest. Third, the market supply and demand situation determines the price. If the demand for this product is strong and the supply is low, the price will rise; if the demand is weak and the supply is sufficient, the price may trend down.
And because I have no real-time business data, it is difficult to know the exact price range of this chemical. If you want to know the details, you can go to the chemical raw material trading platform, or consult the chemical supplier, and ask the quantity and price details in detail to get a more accurate price.

2-Ethoxy-3-trifluoromethyl-5-aminopyridine is a chemical substance, and its storage conditions are extremely critical, which is related to the stability and quality of this substance. According to the principles of chemical storage in ancient books such as "Tiangong Kaiwu", caution should be taken.
First of all, the environment, this substance should be stored in a cool place. Hot sun or high temperature can easily cause its chemical properties to change. High temperature often leads to a significant increase in molecular activity, or intensifies the intermolecular reaction of 2-ethoxy-3-trifluoromethyl-5-aminopyridine, damaging its original structure and properties. Therefore, choose a cool warehouse, the temperature is constant in a low range, to ensure its stability.
Furthermore, drying is also a priority. Moisture is the enemy of many chemical substances, 2-ethoxy-3-trifluoromethyl-5-aminopyridine or react with water, hydrolysis and other changes are possible. Therefore, the storage place must be moisture-proof, and the desiccant can be placed next to it to absorb the surrounding water vapor and create a dry atmosphere.
In addition, oxygen avoidance is also critical. Oxygen is oxidizing, and some groups in 2-ethoxy-3-trifluoromethyl-5-aminopyridine may be easily oxidized and cause deterioration of substances. Sealed storage can be considered to prevent oxygen intrusion, or to fill the storage container with inert gases, such as nitrogen, oxygen barrier.
In addition, good ventilation is required for storage. Even if a lot of protection is taken, or trace amounts of harmful gases are still generated, good ventilation can be dispersed in time to prevent its accumulation from causing safety hazards. And ventilation can maintain the fresh ambient air and reduce the impact of environmental factors on the substance.
Storage of 2-ethoxy-3-trifluoromethyl-5-aminopyridine requires a cool, dry, low-oxygen and well-ventilated condition, so as to ensure that this chemical substance remains stable for a long time without losing its inherent characteristics and quality.