2-Ethoxy-3-pyridineboronicacid

2-Ethoxy-3-pyridyl boronic acid is a crucial reagent in the field of organic synthesis. Its chemical properties are unique, containing boron atoms and pyridine ring structures, and the characteristics of boron atoms give it significant activity in organic reactions.
From the structural point of view, the pyridine ring is an electron-rich aromatic ring, which endows the compound with certain stability and conjugation effect. Ethoxy groups are attached to the pyridine ring, because of its electron supply properties, which affect the electron cloud distribution of the pyridine ring, thereby changing its reactivity. At the same time, the boric acid group (-B (OH) -2) brings unique chemical activity to the compound.
In common chemical reactions, 2-ethoxy-3-pyridyl boric acid can participate in the Suzuki-Miyaura coupling reaction. In this reaction, boric acid groups can be coupled with halogenated aromatics or olefins under the action of palladium catalysts and bases to form new carbon-carbon bonds. This reaction is of great significance for the construction of complex organic molecular structures in the fields of drug synthesis and materials science.
Furthermore, the boric acid groups of this compound can undergo dehydration under appropriate conditions to form corresponding boroxy cyclic compounds. It can also react with some metal ions, thereby changing its physical and chemical properties, showing potential application value in catalysis, sensing and other fields. In addition, due to the existence of pyridine rings, it can also bind with a variety of organic molecules through weak interactions such as π-π accumulation and hydrogen bonding, providing materials for the study of supramolecular chemistry.

2-Ethoxy-3-pyridyl boronic acid, which has a wide range of uses, is often used as a key intermediate in the field of organic synthesis.
First, in the process of pharmaceutical chemistry, it can be used to construct complex molecular structures with biological activity. Because boric acid groups can specifically interact with biological macromolecules such as proteins and enzymes, when developing new drugs, especially small molecule inhibitors for specific targets, 2-ethoxy-3-pyridyl boronic acid can help chemists design and synthesize compounds that fit targets, and optimize the structure to improve the efficacy and selectivity of drugs, contributing to the creation of new drugs.
Second, in materials science, or involved in the preparation of optoelectronic materials. By participating in reactions, materials can be endowed with unique electrical and optical properties. For example, the synthesis of organic materials with specific luminescence properties or charge transport properties may have applications in organic Light Emitting Diodes (OLEDs), solar cells and other fields, which are expected to improve material properties and device efficiency.
Furthermore, in organic synthesis chemistry, it is a powerful tool for building carbon-carbon bonds and carbon-heteroatom bonds. Through classic organic reactions such as Suzuki-Miyaura coupling reaction, 2-ethoxy-3-pyridyl boronic acid can be efficiently coupled with halogenated aromatics, halogenated olefins and other substrates to achieve precise synthesis of complex organic molecules, assisting organic chemists in synthesizing natural products, complex functional molecules, etc., and expanding the boundaries of organic synthesis.

The synthesis method of 2-ethoxy-3-pyridyl boronic acid is of interest in the field of organic synthetic chemistry. There are several methods for its synthesis.
One of them can be started from the corresponding pyridine derivatives. Using 3-halo-2-ethoxy pyridine as the starting material, under suitable reaction conditions, the metal-catalyzed coupling reaction is carried out with the borate ester reagent. If a palladium-catalyzed system is used, 3-halo-2-ethoxy pyridine reacts with pinacol borate in an organic solvent in the presence of a base. In this process, the palladium catalyst can promote the coupling of the halogen atom and the borate group to form the target 2-ethoxy-3-pyridyl borate, and then through the hydrolysis step, 2-ethoxy-3-pyridyl boronic acid can be obtained.
Second, it can also start from the construction of the pyridine ring. Through a suitable organic synthesis step, the pyridine ring structure containing ethoxy group is first constructed, and then the boric acid group is introduced. For example, through a multi-step reaction, a specific substituted pyridine compound is synthesized first, and then a boric acid group is introduced at the 3rd position of the pyridine ring using a suitable electrophilic substitution or nucleophilic substitution reaction, while ensuring that the ethoxy group at the 2nd position is not affected.
In addition, other boron-containing reagents can also be considered to react with pyridine derivatives. If different boric acid reagents are used, under appropriate reaction conditions, they are reacted with 2-ethoxy pyridine derivatives to achieve the introduction of boric acid groups, and then 2-ethoxy-3-pyridine boric acid is synthesized.
All synthesis methods have their own advantages and disadvantages. In practical application, it is necessary to comprehensively consider various factors such as the availability of raw materials, the difficulty of controlling reaction conditions, yield and purity requirements, etc., in order to choose the most suitable synthesis path.

I have not obtained the exact market price of "2-Ethoxy-3-pyridineboronic acid". This compound is a boric acid reagent commonly used in organic synthesis, and its price is determined by many factors.
The first to bear the brunt is purity. If the purity is extremely high, it is suitable for high-end scientific research or drug synthesis, and the impurity requirements are strict, the preparation cost will be high, and the price will also rise. For example, if the purity is above 99%, or the price is several times higher than that of 95% purity.
Furthermore, the amount of output affects the price. In large-scale production, due to the scale effect, the unit production cost may be reduced, and the price can be more affordable. However, if it is customized production in small batches, the unit price may be higher due to cost sharing such as equipment commissioning and raw material procurement.
In addition, the relationship between market supply and demand is also an important part. If there is strong demand from many enterprises or scientific research institutions at a certain time, but the supply is limited, the price will naturally rise; conversely, if the supply exceeds the demand, the price may have room to fall.
There are also differences in pricing strategies of different suppliers. Some suppliers focus on market share, and their pricing may be relatively low to attract customers; while some suppliers rely on their technical advantages or brand influence, and their prices may be slightly higher.
To know the exact market price, it is advisable to consult professional chemical reagent suppliers, such as Sinopharm Group Chemical Reagent Co., Ltd., search banner reagent company, etc., or search on the chemical product trading platform to obtain accurate quotations.

2-Ethoxy-3-pyridyl boronic acid is a commonly used reagent in organic synthesis. When storing and transporting, the following numbers should be paid attention to:
First, the storage temperature is very important. It should be stored in a cool and dry place, usually in a refrigerated environment of 2-8 ° C. This reagent is quite sensitive to temperature, and high temperature can easily cause it to decompose and deteriorate, so it should be avoided where the temperature is too high, and it must not be exposed to direct sunlight or high temperature environment.
Second, moisture resistance is extremely critical. Because of its certain hygroscopicity, it may react after contact with moisture, which affects the quality. Be sure to store in a well-sealed container, and a desiccant can be placed in the storage place to maintain a dry environment and prevent the failure of the reagent due to moisture intrusion.
Third, during transportation, ensure that the packaging is firm. Choose suitable packaging materials, such as strong plastic bottles or glass bottles, and properly wrap with cushioning materials to prevent the container from breaking due to collision and vibration during transportation, resulting in the leakage of reagents.
Fourth, this reagent may have certain chemical activity and potential danger, and the relevant chemical safety regulations must be followed during transportation and storage. Operators should be familiar with its characteristics and emergency treatment methods, and can respond quickly and correctly in the event of an accident such as a leak. For example, if a leak is accidentally made, the scene should be immediately isolated to avoid personal contact, and the leak should be collected and handled in an appropriate manner.