2-(Dimethylamino)pyridine-5-boronic acid hydrate

2-%28Dimethylamino%29pyridine-5-boronic acid hydrate is 2- (dimethylamino) pyridine-5 -boronic acid hydrate, which has a wide range of uses. In the field of organic synthesis, it is often used as an important intermediate. In the construction of complex organic molecular structures, with its boric acid groups, it can participate in many key reactions, such as Suzuki coupling reaction. In this reaction, boric acid compounds can effectively form carbon-carbon bonds with halogenated aromatics or olefins under palladium-catalyzed conditions, which is of great significance in pharmaceutical chemistry, materials science and many other aspects.
In the field of drug development, 2- (dimethylamino) pyridine-5 -boric acid hydrate can help create new drug molecules. With its participation in the reaction, the molecular structure of the drug can be modified and optimized, thereby improving the activity, selectivity and pharmacokinetic properties of the drug.
In the field of materials science, through its participation in organic synthesis reactions, organic materials with special structures and properties can be prepared. For example, synthesizing materials with specific photoelectric properties can be used in organic Light Emitting Diode (OLED), solar cells and other devices, providing key raw materials and pathways for the development of new functional materials. In short, 2 - (dimethylamino) pyridine-5 -boric acid hydrates play an indispensable and important role in organic synthesis, drug development and materials science.

2-%28Dimethylamino%29pyridine-5-boronic acid hydrate is one of the organic compounds. Its physical properties are particularly important, and it is related to many uses and characteristics of this compound.
The properties of this compound may be white to off-white solids under normal conditions. Looking at its color and morphology can be the basis for preliminary identification. As for the melting point, this is an important physical parameter, and the determination of its melting point can help to judge the purity and define the material characteristics. However, the exact melting point value still needs to be determined accurately by experiments, because different preparation methods and purity may be slightly different.
Solubility is also a key physical property. In common organic solvents, such as ethanol, dichloromethane, etc., its solubility may vary. In ethanol, or with a certain solubility, this property makes ethanol a good reaction medium in organic synthesis, which is conducive to reaction and product separation. In dichloromethane, if the solubility is good, it can be used for extraction, purification and other operations.
In addition, the stability of this compound also needs to be considered. In air, it may interact with oxygen, water vapor, etc. In case of moisture, or due to the reaction of the boric acid group contained with water, the structure changes. Therefore, when storing, it needs to be properly stored to prevent deterioration, and it is usually recommended to be placed in a dry, cool and sealed environment.
In summary, the physical properties of 2-%28Dimethylamino%29pyridine-5-boronic acid hydrate, such as properties, melting point, solubility and stability, play a crucial role in its application in organic synthesis, drug development and other fields, and need to be carefully studied and grasped.

2-%28Dimethylamino%29pyridine-5-boronic acid hydrate is 2- (dimethylamino) pyridine-5-boronic acid hydrate, and its synthesis method is as follows.
Suitable pyridine derivatives can be selected as starting materials. One method is: 2-halo-5-nitropyridine is used as the starting material, and the nucleophilic substitution reaction is carried out with dimethylamine first, so that the halogen atom is replaced by dimethylamino. This step of the reaction needs to be carried out in a suitable solvent such as N, N-dimethylformamide (DMF) at a certain temperature and in the presence of bases such as potassium carbonate, which can promote the smooth occurrence of nucleophilic substitution reactions.
Subsequently, the nitro group is reduced. Catalytic hydrogenation can be used, using palladium carbon as a catalyst, in a hydrogen atmosphere in a suitable solvent such as ethanol, to reduce the nitro group to an amino group.
Next, the boric acid group is introduced by a metallization-boration reaction. The pyridine ring is often lithified at low temperature with a strong base such as n-butyl lithium, followed by the addition of a borate ester reagent, such as pinacol borate, to undergo a metal transfer reaction to generate the corresponding borate ester intermediate. Finally, the borate ester intermediate is hydrolyzed to obtain the target product 2 - (dimethylamino) pyridine-5 - boric acid hydrate under acidic or basic conditions.
Another synthetic route, if the starting material is 2-amino-5-halogenated pyridine, the amino group can be protected first to prevent it from interfering in subsequent reactions. The protective group can be selected from tert-butoxycarbonyl (Boc), etc. Then the metallization-boration reaction of halogen atoms is carried out. The steps are similar to the above, the borate ester group is introduced, and finally the protective group is removed and the borate ester is hydrolyzed to obtain the target product. During the synthesis process, attention should be paid to the precise control of the reaction conditions at each step, such as temperature, reaction time, reagent dosage, etc., to improve the yield and purity.

2-%28Dimethylamino%29pyridine-5-boronic acid hydrate is a commonly used reagent in organic synthesis. During storage and transportation, many key matters need to be paid attention to.
The first storage environment should be placed in a cool and dry place. This compound is prone to hydrolysis of boric acid groups due to moisture, which in turn affects its chemical activity and purity. Therefore, high humidity should be avoided in the storage place to prevent its deterioration.
The second is temperature control. Generally speaking, a low temperature environment is conducive to storage. Generally, it is recommended that the storage temperature be between -20 ° C and 0 ° C. If the temperature is too high, it may accelerate the decomposition of the compound and reduce its stability.
Furthermore, the compound is sensitive to oxygen, exposed to air for a long time, or reacts with oxygen to cause structural changes. Therefore, it should be sealed and stored during storage, and inert gases such as nitrogen can be used to protect against contact with oxygen.
In terms of transportation, it is necessary to ensure that the packaging is tight. Appropriate packaging materials should be used to avoid package damage caused by vibration and collision. In view of its chemical characteristics, the transportation process should also maintain low temperature and dry conditions to avoid extreme temperature and humidity environments.
In addition, relevant regulations and safety standards should be followed during transportation, and clear labels and safety data instructions should be provided so that transporters and recipients can understand its characteristics and precautions to ensure transportation safety.
In this way, during the storage and transportation of 2-%28Dimethylamino%29pyridine-5-boronic acid hydrate, strict control of environmental conditions, proper packaging and compliance with regulations can ensure its quality and safety.

2-%28Dimethylamino%29pyridine-5-boronic acid hydrate, that is, 2- (dimethylamino) pyridine-5-boronic acid hydrate, the market price of this product varies for a variety of reasons.
First, the purity of the product has a special impact on the price. If the purity is very high, it can be used for high-end scientific research experiments, and its price is high. For example, if the purity is more than 99%, the price per gram may be more than 100 yuan. Due to the complex purification process, exquisite technology and high cost are required to remove impurities and achieve this high purity.
Second, the source of supply also affects the price. If it is produced by a well-known large factory, its quality control is strict, the product quality is stable, and the price may be high. On the contrary, although the price of the products produced by small factories may be slightly lower, the quality may be difficult to guarantee. And most large factories have complete R & D and after-sales systems, which are also one of the price factors.
Third, the market supply and demand relationship plays a significant role. If for a while, many scientific research institutions or pharmaceutical companies have a large increase in demand for it, but the supply is limited, the price will rise. On the contrary, if the demand is low and the supply exceeds the demand, the price will decline.
Fourth, the packaging specifications are also related to the price. Small packages, such as 1 gram and 5 grams, are suitable for small-scale research due to their ease of access, and the price is relatively high. Large packages, such as 100g and 500g packages, may have preferential prices per gram due to less unit cost sharing.
Roughly speaking, the price of 2- (dimethylamino) pyridine-5-boronic acid hydrate fluctuates between tens of yuan and hundreds of yuan per gram. To know the exact price, you need to consult the relevant chemical raw material suppliers in detail and pay attention to the market dynamics in real time to obtain the exact number.