2-CYANOPYRIDINE-4-BORONIC ACID PINACOL ESTER

2-Cyanopyridine-4-boronic acid pinacol esters are widely used in the field of organic synthesis. This compound is often a key building block for the construction of complex organic molecules.
First, in the carbon-carbon bond formation reaction, it can be used as an electrophilic agent or a nucleophilic agent to participate in the Suzuki coupling reaction. Suzuki coupling reactors are an important means of building carbon-carbon bonds in organic synthesis. In this reaction, 2-cyanopyridine-4-boronic acid pinacol ester can efficiently form carbon-carbon bonds with halogenated aromatics or halogenated olefins in the presence of suitable catalysts (such as palladium catalysts) and bases, resulting in biaryl or alkenyl aryl compounds with specific structures. Such products are essential in the fields of medicinal chemistry and materials science. For example, when creating new drug molecules, the introduction of 2-cyanopyridine-4-boronic acid pinacol ester fragments through Suzuki coupling reaction can construct molecular structures with unique biological activities, laying the foundation for the development of specific drugs.
Second, it is also useful in the synthesis of heterocyclic compounds. The coexistence of pyridine ring with cyano and borate ester groups endows this compound with unique reactivity. Nitrogen-containing heterocyclic compounds with more complex structures can be synthesized by multi-step reactions using them as starting materials. Such heterocyclic compounds are commonly found in natural products, drugs and functional materials.
Furthermore, in the field of materials science, the introduction of 2-cyanopyridine-4-boronic acid pinacol esters into polymer systems through specific reactions can endow materials with special optical and electrical properties. Due to the fact that both pyridine ring and borate ester groups can participate in the intermolecular interaction, the aggregate structure and electron transport properties of materials are affected, thus providing the possibility for the development of new photoelectric materials.

The synthesis method of 2-cyanopyridine-4-boronic acid pinacol ester is described in many ancient books. One method is to use 2-cyano-4-halopyridine as the starting material. This halopyridine can be chlorinated, brominated or iodine. Mix it with pinacol borate, add palladium catalyst, such as tetra (triphenylphosphine) palladium, etc., and alkali substances, such as potassium carbonate, sodium carbonate, etc., in an organic solvent, toluene, dioxane, etc. In the reaction, the halogen atom is substituted with pinacol borate, and the target product is obtained. This process requires attention to the control of reaction temperature and time. The temperature is about 60-120 ° C, and the duration is about 6-12 hours.
Another method is to use 2-cyanopyridine-4-boronic acid as raw material to condensate with pinacol. In organic solvents such as dichloromethane and chloroform, add dehydrating agents, such as concentrated sulfuric acid, p-toluenesulfonic acid, etc., and heat and reflux. The amount of dehydrating agent, reaction temperature and time are all critical. The dehydrating dose should be appropriate, too much or cause side reactions; the temperature is about 40-80 ° C, and the reaction is about 3-8 hours. After the condensation reaction is completed, the pure 2-cyanopyridine-4-borate pinacol ester can be obtained by separation and purification, such as column chromatography, recrystallization, etc.
Another pyridine derivative is prepared by multi-step reaction. First, the pyridine ring is modified, and the related precursors of cyano and borate esters are introduced, and then the target molecular structure is gradually constructed through a series of reactions, such as nucleophilic substitution, oxidation, condensation, etc. However, this method is complicated, requires fine operation, and the reaction conditions of each step are different. The selection of raw materials and the reaction sequence need to be carefully considered to obtain the product with high yield and purity.

2-Cyanopyridine-4-boronic acid pinacol ester, which is a very important chemical substance in the field of organic synthesis. Looking at its physical properties, under normal temperature and pressure, it often appears white to off-white solid. Its melting point is about a specific temperature range, which is of great significance in the identification and purification of this substance. With the method of melting point determination, its purity can be determined. In addition, its solubility also has unique characteristics. In some organic solvents, such as common tetrahydrofuran and dichloromethane, it exhibits good solubility. This characteristic provides a lot of convenience for the design and implementation of organic synthesis reactions. When building the reaction system, a suitable reaction solvent can be selected accordingly to facilitate the smooth progress of the reaction.
In terms of its chemical properties, the cyanyl group and boric acid pinacol ester groups contained in the molecular structure endow the substance with rich chemical reactivity. As a strong electron-absorbing group, cyanyl group can significantly affect the distribution of electron clouds in molecules, making the surrounding carbon atoms appear electron-deficient, so it is prone to nucleophilic addition reactions. For example, it can react with nucleophilic reagents containing active hydrogen, such as water, alcohols, amines, etc., under specific conditions to generate various nitrogen-containing or oxygen-containing derivatives. This reaction is widely used in the construction of complex organic molecular structures. The boric acid pinacol ester group has good chemical activity and selectivity due to the unique electronic structure of boron atoms. In transition metal catalyzed reactions, such as Suzuki coupling reaction, the group can couple with halogenated aromatics or halogenated olefins and other substrates to form carbon-carbon bonds. This reaction is an important means of constructing biphenyls and alkenylated products, and is widely used in many fields such as drug synthesis and materials science. The physical and chemical properties of 2-cyanopyridine-4-borate pinacol esters make them play a key role in the field of organic synthesis chemistry, providing an effective way for the synthesis of many complex organic compounds.

The price of 2 - CYANOPYRIDINE - 4 - BORONIC ACID PINACOL ESTER varies depending on factors such as quality, supply and demand, purchase quantity, and channels, so it is difficult to determine the exact number.
If the purchase quantity is small and it is requested from ordinary chemical reagent suppliers, the price per gram may be around tens of yuan to hundreds of yuan in terms of small packages (such as several grams). Covering such small-scale purchases, merchants may price high considering costs, warehousing, and profits.
If it is for industrial use, the purchase volume is quite large, such as in kilograms. Due to the scale effect, the price per kilogram should be greatly reduced. Or drop to several thousand yuan per kilogram. When the quantity is large, the production and transportation costs are diluted, and the merchants are also willing to let the profit to promote the block trade.
Furthermore, the quality also affects the price. High purity, less impurities, is suitable for high-end scientific research, pharmaceuticals and other fields with strict purity requirements, and its price is high; while the purity is slightly lower, if it is only used for general experiments or industrial preliminary reactions, the price is slightly lower.
And the market supply and demand situation is also the key. If there are many people who demand for a while, the supply is not enough, and the price will rise; on the contrary, if the supply exceeds the demand, the merchant may reduce the price to sell the inventory.
As for the specific price, it is advisable to consult the chemical reagent distributor and chemical raw material supplier, and compare their quotations in detail to obtain a more accurate price range.

2-Cyanopyridine-4-boronic acid pinacol ester is a commonly used reagent in organic synthesis. When storing and transporting, many important items must be paid attention to.
Storage is first mentioned. This substance is quite sensitive to environmental conditions and is first and foremost moisture-proof. Because of its borate structure, it is easy to hydrolyze in contact with water, resulting in its deterioration and failure. Therefore, it should be stored in a dry place or placed in a storage container with a desiccant to keep the environment dry. In addition, the temperature must also be suitable, and it should be avoided from hot topics. High temperature will accelerate its chemical reaction process and damage its stability. In general, it should be stored in a cool place, usually refrigerated at 2-8 ° C, which can slow down molecular activity and prolong its shelf life. In addition, attention should also be paid to avoiding light. Light may cause photochemical reactions and affect its chemical properties, so it should be placed in dark containers such as brown bottles.
As for transportation, there are also many details. Because it is a chemical reagent, it needs to follow relevant regulations and standards when transporting to ensure safe transportation. The packaging must be strong and well sealed to prevent leakage. Leakage will not only cause the loss of reagents, but may also pose a threat to the transportation environment and personnel safety. During transportation, it is also necessary to maintain suitable temperature and humidity conditions to avoid violent vibration and collision. Vibration and collision may cause damage to the package, or cause internal chemical reactions, endangering transportation safety. Transport personnel should also have relevant chemical knowledge, know the characteristics of this reagent and emergency treatment methods, in order to deal with possible unexpected situations.