2-cyanopyridine 1-oxide

The main use of 2-% hydroxypyridine and 1-oxide, covering polyterminal.
2-% hydroxypyridine, in the field of organic synthesis, is often used as a key intermediate. It can participate in various reactions, such as nucleophilic substitution reactions. Due to the conjugation effect of hydroxyl groups and pyridine rings, the electron cloud density distribution of pyridine rings is different, resulting in high reactivity to nucleophiles at some positions. Therefore, multi-functional groups can be introduced to construct complex organic molecules, which make great contributions to the creation of new drug molecules in the field of medicinal chemistry. And because of its certain coordination ability, it can complex with metal ions. In the field of metal organic chemistry, it provides an opportunity for the synthesis of metal complexes with specific structures and properties. Such complexes may exhibit unique catalytic activity in the field of catalysis.
1-oxide is also widely used. In drug preparation, its unique electronic structure and chemical properties can be used to optimize the physicochemical properties of drug molecules, such as solubility and stability. Because the oxygen atom on the nitrogen atom gives the molecule extra polarity, it can enhance the interaction between drug molecules and biological targets, and improve the biological activity and selectivity of drugs. In the field of materials science, 1-oxide can be used as a special structural unit to participate in the synthesis of polymer materials. It can change the electronic structure and spatial configuration of the polymer chain, and then endow the material with specific properties such as conductivity and optical activity, which is very powerful in the preparation of functional polymer materials.
In short, 2-% hydroxypyridine and 1-oxide play an important role in chemical synthesis, drug development, material preparation and other fields, and contribute greatly to the development of various fields.

To prepare 2-hydroxypyridine and 1-oxide, there are many methods, each of which is ingenious.
First, pyridine is used as the starting material and can be obtained by oxidation. Strong oxidizing agents such as hydrogen peroxide and peracetic acid can be selected. Dissolve pyridine in an appropriate solvent, such as glacial acetic acid, slowly drop hydrogen peroxide, and control the temperature. This process requires attention to temperature to prevent side reactions caused by peroxidation and reduce the yield. The principle is that the oxidant oxidizes the nitrogen atom on the pyridine ring to obtain 1-oxide, and then hydroxylates it to obtain 2-hydroxypyridine 1-oxide.
Second, start from 2-chloropyridine. First, 2-chloropyridine is co-heated with sodium hydroxide solution, and after nucleophilic substitution, the chlorine atom is replaced by a hydroxyl group to obtain 2-hydroxypyridine. Then it is oxidized, and the target product can be obtained by using m-chloroperoxybenzoic acid as an oxidizing agent. The key to this path is in the nucleophilic substitution step, which needs to ensure that the reaction is sufficient to improve the yield of 2-hydroxypyridine, and the conditions are controlled in the oxidation step to ensure the appropriate oxidation.
Third, with the help of organometallic reagents. Using 2-bromopyridine as a raw material, first make a Grignard reagent with magnesium powder, and then react with a This process has strict requirements on the reaction environment, requires anhydrous and anaerobic, and the Grignard reagent has high activity. The operation must be careful to make the reaction proceed as expected to obtain the required 2-hydroxypyridine 1-oxide.
Each preparation method has its own advantages and disadvantages. In practical application, when considering many factors such as raw material availability, cost, yield and purity requirements, the optimal method is selected.

2-% hydroxypyridine is an organic compound. Its common physical properties are as follows: This substance is mostly a crystalline solid at room temperature and has a specific melting point. Due to the hydrogen bonding between molecules, the melting point is relatively high, up to 100 ° C. It has a certain solubility in water, and the hydroxyl group can form hydrogen bonds with water molecules. However, its solubility is also affected by the hydrophobicity of the pyridine ring, so the solubility in water is not very high; in organic solvents, such as ethanol and acetone, the solubility will be relatively increased. It also has sublimation, and under appropriate temperature and pressure conditions, it can be directly converted from a solid state to a gaseous state.
1-oxide This kind of compound has different physical properties of 1-oxide. In general, some 1-oxides are colorless to light yellow liquids with pungent odors, and their odors may vary depending on the specific chemical structure. The boiling point of 1-oxides is affected by the molecular structure. Those with greater intermolecular forces have higher boiling points. Some common 1-oxides have boiling points in the range of 100 ° C to 200 ° C. In terms of density, 1-oxides are generally heavier than water and will sink to the bottom when placed in water. In terms of solubility, some 1-oxides can be miscible with water because polar groups in the molecule can interact with water molecules; but some 1-oxides are only slightly soluble in water and more soluble in organic solvents, such as dichloromethane, chloroform, etc., which are closely related to the polarity and structure of their molecules. In terms of volatility, some 1-oxides are highly volatile and volatile in the air, which requires special attention during use and storage.

2-% hydroxypyridine and 1-oxide are two very important types of organic compounds. Their chemical properties are unique and they have significant applications in many fields.
2-hydroxypyridine has acidic properties. Because the hydrogen atom in the hydroxyl group has a certain tendency to dissociate, it can release protons under suitable conditions and is in an acidic state. And this compound can coordinate with metal ions, and complexes with metal ions by virtue of the lone pair of electrons of its hydroxyl oxygen atom to form stable complexes. This coordination property is widely used in the field of catalysis, and can be used as a catalyst or catalyst ligand to affect the rate and selectivity of chemical reactions. Furthermore, 2-hydroxypyridine is also a key intermediate in organic synthesis, and can be converted into more complex organic compounds through various chemical reactions.
As for 1-oxide, taking 2-hydroxypyridine 1-oxide as an example, its chemical properties are also unique. Compared with the parent 2-hydroxypyridine, its electron cloud distribution changes due to the introduction of oxygen atoms. This change causes its nucleophilicity and electrophilicity to be adjusted, and the reactivity is also different. 1-oxide can participate in oxidation-reduction reactions and play an important role in specific chemical reactions as an oxidant or reducing agent. In addition, its interaction mode with other compounds also varies due to structural changes, and can be combined with specific substrates through hydrogen bonding, electrostatic interaction, etc. This property is of great significance in the field of medicinal chemistry, or can be used to design and synthesize drug molecules with specific biological activities.
In summary, the chemical properties of 2-hydroxypyridine and 1-oxide are rich and diverse, providing a broad research and application space for many fields such as organic synthesis, catalysis, and drug development.

Nowadays, what is the market median price of dicarbonyl and monoxide? Let me try to solve it for you.
Dicarbonyl has its own unique properties and wide range of uses. It is used in all industries, but its price is uncertain, and it often varies depending on the purity of the quality and the supply and demand of the market. If the quality is pure and the market needs to be prosperous, the price is high; if the quality is miscellaneous and the demand is low, the price will drop. And the distance of the place of origin and the difficulty of transportation are all variables of the price. In normal circumstances, its price ranges from tens to hundreds of dollars per catty.
As for monoxide, it also has its properties and uses. Common in chemical, metallurgical and other industries. Its price is also affected by supply, demand and quality. In many places of production, the supply exceeds the demand, and the price must be low; and in remote areas, the supply is less and the demand is more, and the price must increase. The price may be between tens and hundreds of dollars per catty.
However, the market is impermanent, and the price is not constant. To know the exact price, you should go to the market in person, ask the merchants, and observe the market conditions before you can get the actual price. These two prices change from time to time, and they change from city to city, and cannot be generalized.