2-Cyano-5-nitro-3-(trifluoromethyl)pyridine

2-Cyano-5-nitro-3- (trifluoromethyl) pyridine is widely used in the fields of chemical industry and medicine.
In the chemical industry, it is often a key intermediate in the synthesis of special functional materials. The unique combination of cyano, nitro and trifluoromethyl in its structure imparts specific properties to the materials made from this raw material. If a specific reaction is carried out, a polymer containing nitrogen heterocycles can be constructed. Due to the introduction of trifluoromethyl, this polymer has excellent chemical stability, weather resistance and low surface energy. It is suitable for the preparation of high-end coatings, special plastics, etc., which can improve the corrosion resistance and wear resistance of materials.
In the field of medicine, it is an important starting material for the synthesis of a variety of biologically active compounds. Cyano, nitro and trifluoromethyl can precisely bind to targets in vivo, affecting the activity and function of biomolecules. Based on it, through a series of chemical modifications and reactions, antibacterial, anti-cancer and other drugs can be developed. For example, studies have found that some derivatives containing this structure can effectively inhibit the proliferation of specific cancer cells, and achieve the purpose of treating cancer by interfering with key metabolic pathways or protein synthesis of cancer cells. It may also affect bacterial cell wall synthesis, nucleic acid metabolism and other links, and exert antibacterial effects.
In addition, it has also emerged in the creation of pesticides. Its special structure can endow pesticides with good environmental compatibility and high-efficiency biological activity, and has a unique mechanism of action against pests and pathogens. It can develop high-efficiency, low-toxicity, and environmentally friendly pesticides to meet the needs of modern agriculture for green and sustainable plant protection products.

There are many methods for synthesizing 2-cyano-5-nitro-3- (trifluoromethyl) pyridine. The first method can be prepared by starting from a suitable pyridine derivative and undergoing a series of reactions such as nitration, cyanidation and the introduction of trifluoromethyl. First take the pyridine derivative, and under suitable reaction conditions, carry out the nitrification reaction with nitrifying reagents such as nitric acid, so that the nitro group is introduced at a specific position on the pyridine ring. In this step, pay attention to the reaction temperature, reagent ratio and other factors to obtain the target nitropyridine derivative.
Then, the obtained nitropyridine derivative is cyanized under specific reagents and conditions to introduce a cyano group. This process may require the assistance of a catalyst, and the conditions such as pH and temperature of the reaction environment are strictly controlled.
Finally, through a suitable method, such as using a trifluoromethyl reagent, reacting with the aforementioned product under appropriate conditions, trifluoromethyl is successfully introduced at the designated position of the pyridine ring, and then 2-cyano-5-nitro-3 - (trifluoromethyl) pyridine is obtained.
Another method can start with the construction of the pyridine ring. First, the pyridine ring skeleton is constructed by cyclization of an appropriate organic compound. This cyclization step requires clever design of the reactant structure and reaction conditions. Subsequently, nitrification, cyanation, and trifluoromethylation are carried out in sequence. Each step of the reaction requires fine regulation of reaction parameters, such as reaction time, temperature, and solvent, to improve the yield and purity of the target product. The desired 2-cyano-5-nitro-3- (trifluoromethyl) pyridine is finally obtained.

2-Cyano-5-nitro-3- (trifluoromethyl) pyridine, this is an organic compound. Its physical properties are related to many aspects, as detailed below.
Looking at its appearance, under room temperature and pressure, it is either a solid state or a crystalline state, mostly white to light yellow solid, but its color may change due to differences in purity. This compound has a specific odor due to specific atoms and groups in its structure, but its odor may be weak and often has irritating characteristics.
The melting point is discussed. Due to factors such as intermolecular forces, its melting point is within a certain range. Specifically, the exact melting point is closely related to the purity of the compound. For high purity, the melting point is relatively fixed, or the phase transition occurs within a narrow temperature range.
In terms of boiling point, due to the existence of cyano, nitro and trifluoromethyl in its molecular structure, the intermolecular force is greatly affected, so the boiling point is high. This is due to the increased intermolecular force. To change the compound from liquid to gaseous state, more energy needs to be input to overcome the intermolecular attractive force.
Solubility is also an important physical property. The solubility of this compound in water is extremely low, because water is a polar solvent, and although the molecular polarity of this compound exists, the interaction between it and water molecules is greatly weakened due to the existence of hydrophobic groups such as cyano, nitro and trifluoromethyl. However, in organic solvents, such as common polar organic solvents acetonitrile, dichloromethane, N, N-dimethylformamide, etc., the solubility is relatively high, because these organic solvents and compound molecules can form such as van der Waals forces, dipole-dipole interactions, etc., which promote the dissolution of the compound.
Density is also one of its physical properties. Due to the specific types and quantities of atoms in the molecule, its density may be different from that of common solvents. In practical operation and application, the characteristics of density affect its distribution and behavior in the system.
In addition, the vapor pressure of the compound is low, due to the strong intermolecular force, at room temperature and pressure, fewer molecules escape from the liquid surface to form steam. This characteristic also requires certain storage and use environments.

2-Cyano-5-nitro-3- (trifluoromethyl) pyridine, this is an organic compound with unique chemical properties and is very important in the field of organic synthesis.
Looking at its chemical structure, cyano (-CN), nitro (-NO 2O) and trifluoromethyl (-CF 🥰) are attached to the pyridine ring. Cyano is a strong electron-absorbing group, which can reduce the electron cloud density of the pyridine ring and cause its chemical activity to change. In nucleophilic substitution reactions, cyano can enhance the reactivity of the pyridine ring against nucleophiles, making it more susceptible to attack by nucleophiles. < Br >
Nitro is also a strong electron-absorbing group, which further reduces the electron cloud density of the pyridine ring. This not only affects the electron distribution of the pyridine ring, but also enhances the polarity of the molecule. The presence of nitro groups changes the stability and reactivity of compounds. Under specific conditions, nitro groups can undergo reduction reactions and be converted into other functional groups such as amino groups (-NH2O), providing a way for the synthesis of nitrogen-containing compounds.
Trifluoromethyl has strong electronegativity and unique spatial effects. Due to its high electronegativity, it greatly affects the electron cloud distribution of the pyridine ring, which significantly reduces the density of ortho and para-potential electron clouds, thus affecting the selectivity of reaction check points. Spatially, trifluoromethyl is large in size, which affects the molecular spatial structure and stereochemistry during reaction, such as hindering the proximity of reagents in some reactions, affecting the reaction rate and product selectivity.
2-cyano-5-nitro-3- (trifluoromethyl) pyridine exhibits unique chemical properties due to the interaction of these functional groups. It can be used as a key intermediate for the preparation of a variety of drugs, pesticides and functional materials. Due to its special electronic and spatial structure, it has broad application prospects in the field of organic synthetic chemistry, laying the foundation for the creation of novel compounds with structures and functions.

I found "2 - Cyano - 5 - nitro - 3 - (trifluoromethyl) pyridine", which is an organic compound. The market price often varies due to various reasons, such as quality, supply and demand, difficulty in preparation, and competition in the market.
In the past, the price of fine chemicals was always regarded as the simplicity of their synthesis. If the preparation requires multiple steps of reaction, rare reagents, or harsh reaction conditions, the price must be high. This compound contains cyanide, nitro and trifluoromethyl, and the synthesis requires delicate steps and special reagents, which is expensive.
And the supply and demand situation also affects its price. If a certain industry has a strong demand for this, but the production is limited, the price will rise; conversely, if the supply exceeds the demand, the price may drop.
Competition in the city is also a major reason. Many enterprises produce this product, in order to compete for the market, or cut the price; independent enterprises monopolize, the price may be controlled by them.
Unfortunately, there is no recent detailed data, it is difficult to determine its price. However, if you want to know its market price, you can consult chemical raw material suppliers, chemical product trading platforms, or check relevant market survey reports to get a more accurate price.