2-Cyano-5-methylpyridine

2-Cyano-5-methylpyridine, which has a wide range of uses and is an important raw material and intermediate in the field of organic synthesis.
First, in the creation of medicine, it is often a key building block. The special structure of the Gainpyridine ring and the cyanyl group endows it with diverse reactivity. It can be ingeniously constructed with complex molecular structures with specific pharmacological activities through a series of chemical reactions, such as nucleophilic substitution and addition. In the process of many drug development, 2-cyano-5-methylpyridine is used as the starting material and carefully reacted in multiple steps to obtain drugs with excellent efficacy.
Second, in the field of pesticides, it also has extraordinary performance. Because its structure can be combined with specific targets in some pests or pathogens, and after rational derivatization, efficient insecticides and fungicides can be prepared. By precisely designing molecules and using their chemical properties, effective control of pests can be achieved to ensure the thriving growth of crops.
Third, in the field of materials science, it has also emerged. Polymer materials with special properties can be prepared by polymerization or copolymerization with other functional monomers. Such materials may have good electrical and optical properties, and have broad application prospects in electronic devices, optical materials, etc. If used to prepare organic Light Emitting Diode (OLED) materials, it is expected to improve its luminous efficiency and stability.

2-Cyano-5-methylpyridine is also an important intermediate in organic synthesis. The synthesis method has been investigated by many predecessors, and is described in detail as follows.
One is the method of using 5-methylpyridine as the starting material. 5-Methylpyridine is first treated with a specific reagent to introduce a suitable substituent, which needs to be able to be converted to cyano in subsequent reactions. If a suitable halogenation reagent is used to halogenate a specific position of 5-methylpyridine, halogenated-5-methylpyridine is obtained. Then, the cyanide reagent is used to react with it, and the halogen atom is replaced by a cyanyl group to obtain 2-cyano-5-methylpyridine. In this process, the halogenation reaction conditions are quite critical, and the temperature and reagent ratio must be precisely controlled, otherwise side reactions will easily occur, affecting the purity and yield of the product. The cyanide reaction also requires suitable solvents and catalysts to promote the smooth progress of the reaction.
The second is from the construction of nitrogen-containing heterocycles. A heterocyclic ring containing 5-methylpyridine structure is constructed through a multi-step reaction, and a cyano group is introduced at an appropriate stage. For example, a specific nitrogen-containing compound and a carbonyl-containing compound are used as the starting materials. After a series of reactions such as condensation and cyclization, a 5-methyl pyridine ring is formed first, and then a cyanide group is introduced at a suitable position through a cyanidation step to obtain the final target product. There are many steps in this route, but if the reaction conditions of each step are properly selected, a higher yield can also be obtained. After each step of the reaction, it needs to be purified and separated to remove impurities and ensure that the reaction proceeds in the desired direction.
Third, the method of transition metal catalysis can be used. With a suitable transition metal catalyst, the cyanogen-containing reagent and a specific unsaturated hydrocarbon compound undergo an addition reaction on the 5-methylpyridine structure to directly generate 2-cyano-5-methylpyridine. This method has the advantages of mild reaction conditions and high selectivity. However, the choice and dosage of transition metal catalysts have a great impact on the reaction, and need to be carefully considered, and the pH and temperature of the reaction system cannot be ignored.
The above synthesis methods have their own advantages and disadvantages. In practical applications, the most suitable method should be selected according to specific needs and conditions to achieve the purpose of efficient synthesis of 2-cyano-5-methylpyridine.

2-Cyano-5-methylpyridine, its physical properties are as follows:
This substance is mostly in a solid state under normal temperature and pressure. Looking at its color, it is usually white to white powder, visible to the eye, and the texture is more uniform and delicate. Smell it, or there is a slight special smell, but the smell is not strong and pungent, so it will not be instantly noticeable.
When it comes to the melting point, it is about a certain temperature range. This temperature is the critical value for a substance to change from a solid to a liquid state. The melting point is crucial for the maintenance and transformation of the substance under specific conditions. In terms of boiling point, at the corresponding temperature, the substance changes sharply from a liquid state to a gaseous state. The value of the boiling point reflects the difficulty of gasification during the heating process. The density of
has a specific value, which characterizes the mass of the substance per unit volume. Compared with other common substances, it can reflect the characteristics of its space occupation and mass distribution. And the solubility of 2-cyano-5-methyl pyridine in water is quite limited, which is a substance that is insoluble in water. However, in some organic solvents, it shows a certain solubility, such as some common organic solvents, which can be miscible with each other. The difference in solubility has a key impact on its separation, purification, and environmental selection involved in chemical reactions.

2-Cyano-5-methylpyridine is also an organic compound. When storing and transporting, be sure to pay attention to many matters to ensure its safety and quality.
First words storage. This compound should be placed in a cool, dry and well-ventilated place. Because the cool environment can avoid its thermal decomposition, the dry state can prevent it from moisture and deterioration, and good ventilation can prevent the accumulation of harmful gases. Do not store with oxidants, acids, etc. Because 2-cyano-5-methylpyridine encounters such substances, it is easy to cause violent chemical reactions and risk of explosion. The storage place should also be kept away from fire and heat sources, and obvious warning signs should be set up to make everyone aware of the danger. In addition, the storage container should be made of corrosion-resistant materials and sealed tightly to prevent leakage.
Second talk about transportation. Before transportation, the container and packaging must be carefully checked to ensure that there is no damage or leakage. During transportation, it is necessary to prevent exposure to the sun, rain, and high temperature. Transportation vehicles should be equipped with corresponding varieties and quantities of fire-fighting equipment and leakage emergency treatment equipment. When loading and unloading, the operator should handle it lightly, and it is strictly forbidden to drop or press it, so as not to damage the package and cause leakage of 2-cyano-5-methylpyridine. And during transportation, do not mix with contraindications to ensure transportation safety.
In short, 2-cyano-5-methylpyridine must be treated with caution at every step of storage and transportation, and operated strictly according to regulations to avoid danger and ensure the safety of personnel and the environment.

It is difficult to determine the market price of 2-cyano-5-methylpyridine. The price of 2-cyano-5-methylpyridine often varies due to many factors, such as supply and demand, manufacturing costs, market competition, and the price of raw materials.
Looking at the market in the past, supply and demand were one of the keys. If there are many applicants and few suppliers, the price will increase; conversely, if the supply exceeds the demand, the price may drop. And the price of raw materials required for its preparation also affects. If the price of raw materials increases and the manufacturing cost increases, the market price will also increase accordingly.
Furthermore, market competition cannot be ignored. < Br >
In addition, changes in the current situation, policies and regulations will also affect its price. For example, tariff adjustments and new environmental protection regulations can cause changes in costs and supply and demand, and then affect the market price.
Therefore, in order to know the exact market price, it is necessary to observe the market dynamics in real time and analyze the various influencing factors in detail in order to obtain a more accurate price. Although it is difficult to determine the current specific price, following this path, you can explore the approximate trend and range of its price.