2-Cyano-3-hydroxypyridine

2-Cyano-3-hydroxypyridine, an important organic compound, has critical uses in many fields.
In the field of medicinal chemistry, it is often a key intermediate in the synthesis of various drugs. Due to its unique chemical structure, it can be modified by a variety of chemical reactions to construct compounds with specific biological activities. For example, by using this as a starting material, clever chemical synthesis methods can be used to prepare drugs that have therapeutic effects on specific diseases, such as drugs for certain inflammatory or neurological diseases. It can interact with specific targets in organisms to regulate physiological processes and achieve the purpose of treating diseases.
In the field of materials science, 2-cyano-3-hydroxypyridine also plays an important role. It can be used to synthesize materials with special properties, such as photovoltaic materials. After rational design and synthesis, the materials involved in the construction may have unique optical or electrical properties, showing potential application value in photovoltaic devices such as Light Emitting Diode and solar cells, and contributing to the development of related fields.
In organic synthetic chemistry, 2-cyano-3-hydroxypyridine, as a key synthetic block, can participate in many organic reactions, such as nucleophilic substitution reactions, cyclization reactions, etc. Through these reactions, complex organic molecular structures can be constructed, expanding the variety and function of organic compounds, and contributing to the continuous development and innovation of organic synthetic chemistry.

The synthesis methods of 2-cyano-3-hydroxypyridine have different paths. First, the corresponding pyridine derivatives can be obtained by a series of reactions of cyanidation and hydroxylation. First, find the pyridine with suitable substituents, use a specific cyanide reagent, under suitable reaction conditions, make it cyanide reaction, and introduce cyanyl groups. Then through the hydroxylation step, the target product is obtained. In this process, the choice of cyanide reagents is very critical, such as inorganic cyanides such as potassium cyanide and sodium cyanide, or organic cyanide reagents with special activities, which can be determined according to the specific reaction requirements. And the reaction temperature and solvent environment will also affect the reaction process and yield. < Br >
Second, from nitrogen-containing heterocyclic compounds, pyridine rings can be formed by cyclization reaction, and cyanide and hydroxyl groups can be introduced simultaneously. Select appropriate starting materials, and under the action of specific catalysts, through intramolecular cyclization and rearrangement, cleverly generate the target structure. This path requires careful design of the structure of the starting material, and requires high activity and selectivity of the catalyst. Different catalysts, such as metal catalysts, organic small molecule catalysts, etc., have different catalytic effects and need to be carefully screened and optimized.
Third, there are also those prepared by biosynthesis. With the help of specific microorganisms or enzymes, synthesis is achieved under milder conditions. This method is green and environmentally friendly, but it requires extremely high requirements for the control and optimization of the biological system. It is necessary to deeply understand the microbial metabolic pathway or the catalytic mechanism of enzymes, and optimize the biological system through genetic engineering to improve the yield and purity of the target product. All synthesis methods have their own advantages and disadvantages, and they need to be carefully selected and optimized according to actual needs and conditions in order to achieve the purpose of efficient synthesis.

2-Cyano-3-hydroxypyridine is an organic compound. Its physical properties, allow me to describe in detail for you.
In terms of its appearance, it is mostly white to light yellow crystalline powder at room temperature and pressure. This form is easy to observe and handle, and is easy to use and operate in many experimental and industrial processes.
As for the melting point, it is about 165-169 ° C. The melting point is the temperature at which a substance changes from solid to liquid. This specific melting point is crucial for identifying the compound and controlling the related reaction process. If the melting point is too high or too low, it can suggest that the purity of the compound has changed, or there are impurities.
In terms of solubility, 2-cyano-3-hydroxypyridine is slightly soluble in water. Water is the source of all things and the medium for many chemical reactions. Slightly soluble in water indicates that its interaction with water molecules is weak. However, it has better solubility in organic solvents such as methanol, ethanol, dichloromethane, etc. This property makes it possible to select suitable organic solvents according to their solubility differences when extracting, separating and purifying the compound to achieve the desired effect.
In addition, its density is also an important physical property. Although the exact value varies or depends on the measurement conditions, the approximate range can reflect the relationship between its mass and volume under specific conditions. Density data are of guiding significance in the measurement and mixing of materials in chemical production, as well as the design of reaction systems.
In addition, the stability of 2-cyano-3-hydroxypyridine is also worth mentioning. Under normal conditions, its chemical properties are relatively stable. In case of extreme conditions such as strong acid, strong base or high temperature, or chemical reactions occur, resulting in changes in its structure and properties. Therefore, it should be properly avoided during storage and use to ensure its quality and efficiency.

2-Cyano-3-hydroxypyridine is one of the organic compounds. It has unique chemical properties and is worth exploring.
This compound contains cyanide (-CN) and hydroxyl (-OH), which give it specific reactivity. Cyanyl is active and can participate in many reactions, such as hydrolysis. Cyanyl can be converted into carboxyl (-COOH) after hydrolysis. In organic synthesis, carboxylic acids are often constructed by this method. And cyanyl can undergo nucleophilic addition reactions, react with compounds containing active hydrogen, such as water, alcohols, etc., under specific conditions to generate corresponding addition products.
Hydroxyl groups also have important chemical properties. It is acidic, although less acidic, but under the action of suitable bases, protons can be lost to form corresponding salts. Hydroxyl groups can participate in esterification reactions, react with carboxylic acids under acid catalysis to form ester compounds, which is a common method for preparing esters in organic synthesis. At the same time, hydroxyl groups can be oxidized, and can be converted into aldehyde groups (-CHO), carbonyl groups (C = O) or carboxylic groups depending on the oxidation conditions.
2-cyano-3-hydroxypyridine has more complex and rich chemical properties due to the interaction of functional groups it contains. In the field of organic synthesis, with its unique properties, it can be used as a key intermediate for the synthesis of organic compounds with diverse structures, and has potential application value in many fields such as medicinal chemistry and materials science.

In the market, the price of 2-cyano-3-hydroxypyridine varies widely due to many reasons. Its price often varies depending on the source of production, quality, and supply and demand.
In the past, if this product was abundant and supplied, its price may be stable and still low. However, if the source of production is in trouble, such as natural disasters or man-made disasters, or there are many people seeking but not enough supply, the price will rise.
And its quality is also related to the price. Those who are refined and flawless have a high price; those who contain miscellaneous damage have a low price. In market trade, every business prices according to quality, and the advantages and disadvantages are different.
Looking at past market conditions, the price may range from a few yuan per gram to a few tens of yuan. However, this is not a fixed number, and it may rise or fall recently due to changes in the price of chemical raw materials, or due to new innovations in synthetic technology.
To know the exact price, you must carefully study the current market conditions, visit merchants, and consult the industry to obtain a near-real price. The market situation is changing rapidly. Only by paying attention at all times can you know the good way to know its price.