2-Cyano-3-hydroxpyridine

2-Cyano-3-hydroxypyridine is an organic compound. It has a wide range of uses and has important applications in many fields.
Bearing the brunt, this compound plays a key role in the field of medicinal chemistry. Due to its unique chemical structure, it can be used as a key intermediate for the synthesis of a variety of drugs. For example, when developing drug molecules with specific biological activities, 2-cyano-3-hydroxypyridine can be used as a basic structural unit to construct complex drug molecules with specific pharmacological effects through a series of chemical reactions. By modifying and modifying its structure, the activity, selectivity and pharmacokinetic properties of drugs can be regulated, thus laying the foundation for the creation of new drugs.
Furthermore, in the field of materials science, 2-cyano-3-hydroxypyridine also shows unique value. It can be used to prepare functional materials, such as organic luminescent materials. Due to its molecular structure endowing it with specific optical properties, through rational design and synthesis, organic luminescent materials with high luminescence efficiency can be prepared that can emit specific wavelengths of light, and have potential applications in display technology and lighting fields.
In addition, in the field of organic synthetic chemistry, this compound is often used as an important reaction substrate or reagent. With its cyano and hydroxyl activities, it can participate in a variety of organic reactions, such as nucleophilic substitution reactions, condensation reactions, etc., providing an effective way to construct diverse organic compound structures. Through ingenious design of reaction routes and the use of the characteristics of 2-cyano-3-hydroxypyridine, organic compounds with novel structures and unique functions can be synthesized, promoting the development of organic synthesis chemistry.

The synthesis method of 2-cyano-3-hydroxypyridine has been investigated by many parties throughout the ages, and this is a detailed description for you.
First, the compound containing the pyridine ring can be started. First, take a suitable pyridine derivative and introduce a cyanyl group and a hydroxyl group at a specific position. To introduce a cyanide group, a cyanide reagent, such as potassium cyanide, sodium cyanide, etc. is often used. Under suitable reaction conditions, the cyanide group is connected to the pyridine ring by a reaction mechanism such as nucleophilic substitution. The introduction of hydroxyl groups can be achieved by means of different starting materials, hydrolysis reactions, or nucleophilic addition reactions. If the raw material contains a halogen atom on the pyridine ring, the halogen atom can be replaced with a cyanide group by a cyanide reagent, and then hydrolysis and other steps can be taken to generate a hydroxyl group at the target position. This is a method.
Second, the strategic synthesis of the construction of the pyridine ring. For example, through a multi-step reaction, the pyridine ring is gradually constructed from nitrogen-containing and carbon-containing small molecules, and the cyanyl group and hydroxyl group are precisely introduced during the ring construction process. Nitrogen-containing compounds and carbonyl-containing compounds can be used to form the prototype of the pyridine ring through a series of reactions such as condensation and cyclization. In subsequent reactions, cyanyl and hydroxyl groups are introduced using suitable reagents and reaction conditions. For example, with β-dicarbonyl compounds and ammonia or amines, under the action of appropriate catalysts, pyridine rings are formed by condensation cyclization, and then cyanide, cyanide, hydrolysis and other steps are used to introduce cyanyl groups at the 2-position of the pyridine ring, and hydroxyl groups at the 3-position.
Third, there are also methods of catalysis by transition metals. Transition metals are used as catalysts, such as palladium, copper and other metal catalysts, and groups containing cyanide groups and hydroxyl groups are connected to the pyridine ring by means of coupling reactions. Select a suitable pyridine substrate, and react with cyano- and hydroxyl-containing reagents in the presence of transition metal catalysts, ligands, and suitable bases to achieve the synthesis of 2-cyano-3-hydroxypyridine. This method often has the advantages of mild reaction conditions and high selectivity, and has attracted much attention in recent years.
All synthesis methods have their own advantages and disadvantages. According to actual needs, consider the availability of raw materials, the difficulty of reaction conditions, and the high yield. Choose a suitable method to form this compound.

2-Cyano-3-hydroxypyridine, this is an organic compound. Its physical properties are unique, let me tell you one by one.
Looking at its appearance, it is often in the state of white to light yellow crystalline powder. This is quite common in many organic compounds. Small particles are concentrated, which are loose like powder, and the color is elegant, reflecting the characteristics of its molecular structure.
The melting point is about 220-224 ° C. The melting point is an important physical property of a substance. At this temperature, the compound gradually melts from a solid state to a liquid state. This value indicates the characteristics of its intermolecular forces and lattice structure. Melting in such a temperature range means that a specific energy is required to break the lattice binding, the molecule is energized and the activity intensifies, and the lattice disintegrates to cause a state transition.
Its solubility is also a key property. In common organic solvents, such as dimethyl sulfoxide (DMSO), N, N-dimethylformamide (DMF), it has good solubility. Because the molecules of these organic solvents and 2-cyano-3-hydroxypyridine molecules can form interactions such as hydrogen bonds and van der Waals forces, the solvent molecules can surround the solute molecules and disperse them uniformly in the system. However, in water, the solubility is poor. Due to the limited compatibility between the polarity of water and the molecular structure of the compound, the interaction between water molecules and solute molecules is difficult to defeat the interaction between solute molecules themselves, so it is difficult to dissolve.
The physical properties of 2-cyano-3-hydroxypyridine are of great significance for its application in organic synthesis and medicinal chemistry. Its appearance and melting point can help to identify and judge the purity, while its solubility affects the selection of reaction medium and subsequent separation and purification operations, laying the foundation for related research and applications.

2-Cyano-3-hydroxypyridine is an organic compound. Its chemical properties are unique and diverse.
Looking at its structure, cyano (-CN) and hydroxyl (-OH) coexist on the pyridine ring, which makes the compound have special reactivity. Cyano is a strong electron-absorbing group, while hydroxyl has a certain electron-emitting effect. The interaction between the two affects the chemical behavior of the compound.
On the nucleophilic substitution reaction, the presence of cyano reduces the electron cloud density of the pyridine ring. Under suitable conditions, the carbon atoms on the ring are easily attacked by nucleophilic reagents, resulting in substitution reactions. The oxygen atom of the hydroxyl group is rich in solitary pairs of electrons, which can be used as a nucleophilic check point to react with electrophilic reagents to form new chemical bonds.
In terms of acid-base properties, the hydrogen atom of the hydroxyl group is acidic to a certain extent. Under alkaline conditions, it is easy to dissociate hydrogen ions and form corresponding salts. At the same time, the nitrogen atom of the pyridine ring contains solitary pairs of electrons, which can accept protons and is alkaline to a certain extent, so 2-cyano-3-hydroxypyridine can react with acids or bases.
In addition, the compound may also participate in redox reactions. Hydroxyl groups can be oxidized to oxygen-containing functional groups with higher valence states such as carbonyl groups, and cyano groups can also undergo reduction reactions under specific conditions to convert into amino groups and other groups. This variety of reactivity has made 2-cyano-3-hydroxypyridine popular in the field of organic synthesis, and is often a key intermediate for the preparation of complex organic compounds.

There is a question today, what is the market price of 2-cyano-3-hydroxypyridine. This is a product in the field of fine chemicals, and its price often varies according to many reasons.
One is related to output. If the product is abundant in the market and the supply is abundant, its price may become more affordable according to the reason of supply and demand. On the contrary, if the output is scarce and the supply is in short supply, the price will rise. Second, the price of raw materials is also related. If the price of the raw materials for preparing this pyridine derivative fluctuates, the price of the finished product will also change. If the price of raw materials is high, the price of the finished product will also be high; if the price of raw materials is low, the price of the finished product may decrease.
Third, the preparation method and process are also the main reasons. If the preparation method is complicated, requires many steps, consumes many reagents and energy, the cost will be high and the price will be high. And the efficient and simple process may reduce the cost and reduce the price.
Fourth, the market demand is also the key. In the pharmaceutical, pesticide and other industries, the demand for this product is strong, and the price may rise; if the demand is low, the price may also drop.
As for the current exact price, it is difficult to hide it. For details, you can consult chemical product suppliers, traders, or check chemical product information platforms. The prices quoted by different merchants may vary, and factors such as quality and quantity need to be considered. In conclusion, the market price of Ximing 2-cyano-3-hydroxypyridine needs to be investigated comprehensively and investigated by many parties before a more accurate price can be obtained.