2-Cyano-3-Fluoropyridine,3-Fluoro-2-Pyridinecarbonitrile

2-Cyano-3-fluoropyridine (2-Cyano-3-Fluoropyridine), also known as 3-Fluoro-2-Pyridinecarbonitrile, has a wide range of uses and has important applications in many fields.
First, in the field of medicinal chemistry, it is a key organic synthesis intermediate. It can be used to construct complex drug molecules through a series of chemical reactions. It is often used as a starting material in the development and preparation of many antibacterial, anti-inflammatory and anti-tumor drugs. Due to its unique chemical structure, it can endow drugs with specific biological activities and pharmacological properties, help drugs to accurately act on targets, improve efficacy and reduce side effects.
Second, in the field of materials science, it also has important value. It can participate in the preparation of functional polymer materials, organic optoelectronic materials, etc. In the synthesis of organic Light Emitting Diode (OLED) materials, the introduction of this structure can optimize the photoelectric properties of materials, such as improving luminous efficiency and prolonging the service life of materials, and promote the development of display technology.
Third, in the field of pesticide chemistry, it is an important building block for the synthesis of new pesticides. With its special chemical properties, the synthesized pesticide has an efficient control effect on specific pests or weeds, and has a small impact on the environment, which is in line with the current development needs of green and environmentally friendly pesticides.
Fourth, in organic synthetic chemistry, as a reaction substrate, it participates in many organic reactions, such as nucleophilic substitution reactions, metal catalytic coupling reactions, etc., providing an effective way to construct diverse organic molecular structures, greatly enriching the variety of organic compounds, and promoting the development of organic synthetic chemistry.

2-Cyano-3-fluoropyridine (2-Cyano-3-Fluoropyridine), also known as 3-fluoro-2-pyridinitrile (3-Fluoro-2-Pyridinecarbonitrile), is synthesized as follows:
First, 3-fluoropyridine is used as the starting material. First, 3-fluoropyridine is reacted with a strong base (such as n-butyl lithium) in an appropriate solvent (such as dichloromethane, etc.) under low temperature conditions (such as -78 ° C), so that the hydrogen at the 2-position on the pyridine ring is replaced by lithium to generate the corresponding lithium intermediate. After that, a cyanide reagent (such as cuprous cyanide) is added to the reaction system, and a nucleophilic substitution reaction can introduce a cyano group at the 2-position to obtain 2-cyano-3-fluoropyridine. This method requires low temperature operation and requires high reaction equipment and conditions, but the reaction steps are relatively simple and the yield is acceptable.
Second, use 2-chloro-3-fluoropyridine as raw material. In a suitable organic solvent (such as N, N-dimethylformamide), add cyanylation reagents such as sodium cyanide or potassium cyanide, and add an appropriate amount of phase transfer catalyst (such as tetrabutylammonium bromide). Heating the reflux reaction, the chlorine atom is replaced by cyano to realize the synthesis of 2-cyano-3-fluoropyridine. This method is relatively simple to operate and the conditions are relatively mild, but attention should be paid to the purity and source of the raw material 2-chloro-3-fluoropyridine, and the amount of phase transfer catalyst will affect the reaction.
Third, a coupling reaction catalyzed by transition metals. Using 3-fluoro-2-boronic acid pyridine ester and cyanylation reagents (such as zinc cyanide, copper cyanide, etc.) as raw materials, under the action of transition metal catalysts (such as palladium catalysts, such as tetra (triphenylphosphine) palladium), under the presence of appropriate bases (such as potassium carbonate, etc.), the reaction is carried out in an organic solvent (such as a mixed solvent of toluene and water). This method has high selectivity and good yield, but the catalyst is relatively expensive and the post-reaction treatment may be cumbersome.
These three synthesis methods have their own advantages and disadvantages. In practical application, the appropriate synthesis path should be comprehensively considered according to specific conditions, such as the availability of raw materials, the controllability of reaction conditions, and cost.

2-Cyano-3-fluoropyridine (2-Cyano-3-Fluoropyridine), also known as 3-fluoro-2-pyridinitrile (3-Fluoro-2-Pyridinecarbonitrile), is a kind of organic compound. Its unique physical and chemical properties are quite important in the field of organic synthesis.
When it comes to physical properties, this compound is mostly solid under normal conditions, and the melting point and boiling point vary depending on the precise determination conditions. Generally speaking, the melting point is in a specific temperature range, which can be used as an important basis for the separation and purification of substances. Due to its structure containing cyanyl and fluorine atoms, the intermolecular forces are different, resulting in its melting and boiling point showing unique values.
Looking at its chemical properties, cyanyl groups have high reactivity. It can participate in many chemical reactions, such as hydrolysis. Under specific acid and base conditions, cyanyl groups can be converted into carboxyl or amide groups; it can also perform nucleophilic addition reactions and interact with various nucleophilic reagents. The existence of fluorine atoms, due to the extremely high electronegativity of fluorine, changes the electron cloud density distribution of the pyridine ring, which affects the reactivity and selectivity of compounds. In electrophilic substitution reactions, the ortho-site localization effect of fluorine atoms is significant, which can guide the reaction to a specific location. And fluorine-containing compounds often have special biological activities, which have attracted extensive attention in the field of medicinal chemistry. 2-cyano-3-fluoropyridine or fluorine atoms and cyano groups interact synergistically to exhibit unique physiological activities and may have potential applications in the development of new drugs.

The price of 2-cyano-3-fluoropyridine, also known as 3-fluoro-2-pyridineformonitrile, is difficult to determine in the market. Its price often varies according to time, place, quality, quantity and supply and demand trends.
I have heard that in the chemical industry, the price of various materials is still changing, and there is no constant rule. If this product is of high quality and large quantity, the price may be slightly cheaper; if the quality is rare and there are many people who want it, the price will be high. In the past, its price fluctuated up and down due to the relaxation of market supply and demand. Or at some point, the price can be as low as a few gold per gram; and when raw materials are scarce and demand is booming, the price may jump to tens of gold per gram.
Furthermore, the pricing of different suppliers is also different. Big businesspeople, with the benefit of scale, may be able to offer prices that are close to the people; while hawkers, due to cost, the price may be slightly higher. And regional differences also have an impact. Prosperous and connected cities, convenient transportation, smooth logistics, prices may be stable; while remote places, difficult transshipment, prices may rise.
Therefore, in order to know the exact price of 2-cyano-3-fluoropyridine and 3-fluoro-2-pyridyl-formonitrile, it is necessary to inquire about the quotient of chemical materials, or to observe the real-time market conditions.

2-Cyano-3-fluoropyridine (2-Cyano-3-Fluoropyridine), also known as 3-fluoro-2-pyridinitrile (3-Fluoro-2-Pyridinecarbonitrile), the manufacturer of this compound is available in all parts of the world.
In the Central Plains, many chemical companies are involved in this industry. With their deep chemical foundation and exquisite skills, they have worked hard in the production process and strive for high quality products. Its production facilities are complete and its technical force is strong. It is unique in the synthesis and purification of 2-cyano-3-fluoropyridine. The products are widely used in medicine, pesticides and many other fields.
Jiangdong area, there are also many manufacturers of this compound. The water transportation here is convenient and resources are pooled, providing many conveniences for chemical production. Manufacturers pay more attention to technological innovation and R & D investment, and work hand in hand with local universities and scientific research institutions to continuously optimize production processes, improve product quality and output efficiency. The 2-cyano-3-fluoropyridine produced has a good reputation in the market and is sold far and wide.
In the land of Lingnan, some enterprises focus on the production of 2-cyano-3-fluoropyridine with flexible business strategies and advanced management models. They are good at capturing market trends, adjusting production plans in a timely manner, and under the concept of environmental protection, pay attention to the application of clean production processes, so that the production process is both efficient and environmentally friendly. Their products not only meet the needs of the domestic market, but also make a name for themselves in overseas markets.
In the area of Saibei, some enterprises have unique characteristics in the production of 2-cyano-3-fluoropyridine by virtue of their local resource advantages. They adapt to local conditions, plan the production layout rationally, ensure product quality while effectively controlling costs, and occupy a place in the market with cost-effective products.
In summary, the manufacturers of 2-cyano-3-fluoropyridine are widely distributed, and all local manufacturers have their unique advantages and characteristics to jointly promote the production and application of this compound.