2-Cyano-3,5-difluoropyridine

2-Cyano-3,5-difluoropyridine has a wide range of uses. In the field of medicinal chemistry, it is often used as a key intermediate to help synthesize many compounds with specific biological activities. For example, when developing new antibacterial drugs, using this as a starting material, through delicate chemical reaction steps, molecular structures with unique antibacterial mechanisms can be constructed, providing new possibilities for combating drug-resistant bacteria.
In the field of pesticides, it also plays an important role. It can participate in the synthesis of highly efficient, low-toxic and environmentally friendly pesticides. Due to its unique structure, the synthesized pesticides can specifically act on specific targets of pests, enhancing the efficacy while reducing the adverse effects on non-target organisms and the environment. For example, in the research and development of pesticides against some stubborn pests, 2-cyano-3,5-difluoropyridine participates in the construction of active ingredients, which can precisely attack the nervous system or physiological metabolism of pests and effectively control pests.
Furthermore, in the field of materials science, it can be used as a synthetic block of functional materials. Materials with special optical and electrical properties are prepared by reacting with other organic or inorganic compounds. For example, in the field of organic optoelectronic materials, materials with high absorption and emission properties for specific wavelengths of light are synthesized by using their structural characteristics, which are expected to be applied to new display technologies or optoelectronic devices.

2-Cyano-3,5-difluoropyridine is an important compound in organic chemistry. Its physical properties are quite unique, let me tell them one by one.
Looking at its appearance, it is often colorless to light yellow liquid or solid. The melting point and boiling point of this substance are of key significance to its existence and application under different conditions. However, the exact melting point and boiling point values often vary depending on the purity of the substance and the determination conditions. Generally speaking, its melting point is within a specific range. This range is summarized from a large number of experimental data, but the exact value still needs to be determined according to specific experiments. The boiling point is also the same, which is affected by many factors, but fluctuates roughly within a certain range.
In terms of solubility, 2-cyano-3,5-difluoropyridine exhibits different solubility characteristics in common organic solvents. In some organic solvents such as dichloromethane and chloroform, its solubility is quite good, and it can be well miscible with these solvents. This characteristic makes the selection of such solvents as the reaction medium in the process of organic synthesis can effectively promote the smooth progress of chemical reactions involving 2-cyano-3,5-difluoropyridine. However, in water, its solubility is relatively poor, which is due to the characteristics of its molecular structure. The existence of cyano and fluorine atoms in the molecule affects the interaction between them and water molecules, so it is difficult to dissolve in water. < Br >
Density is also one of its important physical properties. Its density value reflects the compactness of the substance. In practical applications such as separation and purification, density data can provide an important basis for the design and implementation of related processes. Accurate determination of its density is also indispensable for accurately grasping the behavior of the substance in the mixed system.
In addition, the vapor pressure of 2-cyano-3,5-difluoropyridine cannot be ignored. The magnitude of vapor pressure is closely related to temperature, and with the increase of temperature, the vapor pressure increases. This property affects the balance between the vapor and liquid phases of the substance, and plays a key role in the selection and control of operating conditions in separation processes such as distillation.
In conclusion, the physical properties of 2-cyano-3,5-difluoropyridine are of great value in organic synthesis, chemical production, and related scientific research fields. Only by deeply understanding and accurately grasping their physical properties can they be better utilized.

The synthesis method of 2-cyano-3,5-difluoropyridine, although it is not contained in the ancient book "Tiangong Kaiwu", can follow the current method of organic synthesis chemistry.
First, 3,5-difluoropyridine is used as the starting material and can be obtained by cyanidation. This cyanidation reaction can use cyanidation reagents such as potassium cyanide (KCN) or sodium cyanide (NaCN). Under suitable reaction conditions, in an organic solvent, the cyanyl group replaces the corresponding hydrogen atom at a specific position on the pyridine ring of 3,5-difluoropyridine. It should be noted that cyanide is highly toxic, and safety procedures must be strictly followed during operation. Handle with caution in a well-ventilated environment. < Br >
Second, a fluorine-containing pyridine derivative can be used to introduce a suitable substituent first, and a cyanyl group can be constructed through a series of reactions. If the pyridine derivative is halogenated first, a halogenated pyridine is obtained, and then a cyanyl group is introduced through a nucleophilic substitution reaction with a cyanide reagent. In this halogenation reaction, a suitable halogenating reagent and reaction conditions can be selected according to the characteristics of the substrate. When nucleophilic substitution is used, a suitable solvent and base are selected to promote the smooth progress of the reaction.
Third, a compound containing a pyridine structure is used as the starting material, and fluorine atoms and cyanyl groups are gradually introduced through a multi-step reaction. For example, a pyridine skeleton is constructed first, and then a fluoride atom is introduced through a The fluorination reaction can use electrophilic fluorination reagents or nucleophilic fluorination reagents, depending on the specific substrate and reaction path. The cyanide introduction steps also refer to the above cyanide reaction methods.
Synthesis methods have their own advantages and disadvantages. In practical applications, it is necessary to comprehensively consider factors such as raw material cost, reaction conditions, yield and purity, and choose the optimal path to achieve the purpose of efficient synthesis of 2-cyano-3,5-difluoropyridine.

The price of 2-cyano-3,5-difluoropyridine on the market is difficult to determine. The price of this compound is influenced by various factors.
First, the price of the raw material is the main factor. If the raw material for preparing this pyridine derivative is easy and affordable, its price may be slightly lower; conversely, if the raw material is rare and rare, the price must be high.
Second, the preparation method is also important. If the preparation method is simple and efficient, with less energy consumption and time consumption, the cost will decrease, and its price in the market will also be lower; if the preparation method is difficult, requires multi-step reactions, and there are many side reactions, the yield is low, the cost will be high, and the price will be high.
Third, the market supply and demand situation is related to the price. If there are many people who want it, and there are few people who supply it, the price will rise; if the supply exceeds the demand, the price may fall.
Fourth, the scale of production also has an impact. Large-scale production often results in a cost reduction due to the scale effect, and the price may be close to the people; small-scale production, the cost is difficult to control, and the price may be expensive.
In summary, the market price of 2-cyano-3,5-difluoropyridine varies due to raw materials, production methods, supply and demand, scale, etc. To determine its price, it is necessary to carefully consider the current market conditions and various factors, or consult suppliers to obtain a near-real price.

2-Cyano-3,5-difluoropyridine is a key intermediate in the field of organic synthesis and is widely used in many fields such as medicine and pesticides. However, the exact manufacturer of it is difficult to obtain a complete and accurate list after detailed investigation of ancient books and inquiries in the industry.
This compound has not been available for a long time. Although it has been mentioned in some cutting-edge studies, industrial production has not been widely spread due to technical barriers, market demand and other reasons. Therefore, if you want to find a manufacturer, you can start from the following ways: First, visit the chemical product database, such as SciFinder, Reaxys, etc., such databases often contain information on the production of many chemical substances, or you can find one or two clues; Second, go to a professional chemical exhibition in person, during which chemical companies gather, and you can consult relevant manufacturers directly; Third, check academic literature and patents in detail, and some research and development results may have been put into production, or you can trace the source to find the manufacturer.
Although it is difficult to know the exact manufacturer at the moment, follow the above path to explore in detail, or have the opportunity to find relevant information to solve the need.