2-Chloropyridine-6-Carboxylate Methyl

Methyl 2-chloropyridine-6-carboxylate has a wide range of uses. In the field of medicinal chemistry, it is a key intermediate. It can be skillfully converted into compounds with specific pharmacological activities through a series of delicate chemical reactions, paving the way for the creation of drugs for the treatment of various diseases. For example, when developing antibacterial drugs, with its unique chemical structure, it carefully reacts with other reagents to construct a new molecular structure that exhibits excellent inhibitory effect on specific pathogens, like a sharp blade that can accurately hit the target, providing a powerful "weapon" for fighting pathogens.
In the field of pesticide chemistry, it also plays a pivotal role. After chemical modification and synthesis, efficient insecticides and fungicides can be created. Due to its structural characteristics, it can effectively act on the nervous system of pests or the physiological metabolic pathways of pathogens, just like cleverly activating the internal organs of the enemy, causing serious damage to the life activities of pests and pathogens, so as to achieve good pesticide control effects, protect the thriving growth of crops, and protect the harvest of farmland like a loyal guard.
In addition, in the emerging field of materials science, methyl 2-chloropyridine-6-carboxylate has also emerged. With its special chemical activity, it can participate in the synthesis of polymer materials as functional monomers, endowing materials with unique properties such as special optical and electrical properties. It is like injecting magic into materials, opening up a new direction for the development of new functional materials, and promoting the field of materials science to new heights.

2-Chloropyridine-6-carboxylic acid methyl ester, this is a kind of organic compound. Its physical properties are quite critical and are of great significance in chemical research and industrial applications.
Looking at its properties, under room temperature and pressure, 2-chloropyridine-6-carboxylic acid methyl ester is mostly colorless to light yellow liquid with clear texture and no obvious impurities visually. Its smell is unique, although not pungent, it has certain characteristics. This smell can be used as a reference when identifying the substance.
Talking about the melting point, due to the limitation of relevant data, it cannot be accurately known. However, the melting point of such compounds is usually low, and it is estimated that the melting point of methyl 2-chloropyridine-6-carboxylate may be between -20 ° C and 20 ° C. The melting point is affected by many factors such as intermolecular forces and structures. In the molecular structure of this compound, the pyridine ring is connected to the ester group, which affects the intermolecular arrangement and force to a certain extent, and then affects the melting point.
In terms of boiling point, it is about 230 ° C - 240 ° C. The value of boiling point reflects the energy required for the substance to change from liquid to gaseous state. A higher boiling point indicates that the intermolecular force is stronger, and more energy is required to overcome the attractive force to make the molecule escape from the liquid phase. Due to the conjugated structure of the pyridine ring and the existence of the ester group, the intermolecular force is relatively large, so the boiling point is high.
The density is about 1.2-1.3 g/cm ³. The density is related to the molecular weight of the substance and the degree of intermolecular accumulation. The molecule of this compound contains chlorine atoms, pyridine rings and ester groups and other structural units, so that its relative molecular weight is large, and the molecular arrangement is relatively tight, and the density is in this range.
Solubility is also an important physical property. Methyl 2-chloropyridine-6-carboxylate is slightly soluble in water, but it is soluble in a variety of organic solvents, such as ethanol, ethyl ether, dichloromethane, etc. It is slightly soluble in water, because its molecular polarity is relatively small, and the force between it and water molecules is weak. The polarity of the organic solvent is similar to that of the compound, and it can be well miscible according to the principle of "similar miscibility". This solubility characteristic plays a key role in its separation, purification and selection of chemical reaction media.

There are several common methods for preparing methyl 2-chloropyridine-6-carboxylic acid.
One is to use 2-chloropyridine-6-carboxylic acid as the starting material to make it and methanol esterification reaction under acid catalysis. In this process, sulfuric acid, p-toluenesulfonic acid, etc. can be selected as catalysts. Mix the reactants in an appropriate solvent, such as toluene, dichloromethane, etc., and heat and reflux. During the reaction, pay attention to the control of temperature, generally 60-100 ℃ is appropriate. If the temperature is too high or side reactions occur, it will affect the purity of the product. After the reaction is completed, the acid and unreacted raw materials are removed by washing with water and alkali washing, and then dried and distilled to obtain the target product.
The second is to first convert 2-chloropyridine-6-carboxylic acid into its acid chloride form, and reagents such as oxalyl chloride and dichlorosulfoxide can be used. The acid chloride generated is more active than carboxylic acid, and then reacts with methanol to form an ester. The reaction conditions of this method are relatively mild and the reaction rate is relatively fast. During operation, the acid chloride is added dropwise to methanol at low temperature. After the reaction is completed, the product can also be purified by regular post-treatment steps such as vacuum distillation.
Furthermore, metal-organic reagents can be used to participate in the reaction. For example, 2-chloropyridine-6-carboxylate is reacted with halomethane in the presence of palladium, copper and other metal catalysts and ligands. This kind of reaction requires a strict anhydrous and anaerobic environment, and requires high reaction equipment and operation. However, its selectivity is good, which can effectively avoid side reactions in other locations, thereby improving the yield and purity of the product.

Methyl 2-chloropyridine-6-carboxylate requires attention to many matters during storage and transportation.
This chemical has certain chemical activity. When storing, the first choice is the environment. It should be placed in a cool, dry and well-ventilated place to prevent moisture and heat. Humidity can easily cause reactions such as hydrolysis, which can deteriorate the substance; high temperature may also cause decomposition or accelerate chemical reactions, which will damage its quality. And keep away from fire and heat sources. Because of its flammability, it may be dangerous to burn and explode in case of open flames and hot topics.
Furthermore, the material of the storage container is also critical. Corrosion-resistant containers should be used because the substance may react with certain materials. Glass containers are usually more suitable because they are chemically stable and difficult to react with chemicals. However, if the storage capacity is large, metal containers can also be used, but it is necessary to ensure that the inner walls are specially treated to prevent corrosion.
During transportation, the packaging must be tight. Packaging materials that meet relevant standards should be selected to ensure that the packaging is not damaged or leaked during handling, loading and unloading. And transportation vehicles need to be equipped with corresponding fire protection equipment and emergency treatment equipment for emergencies. Transport personnel should also be familiar with the characteristics of the chemical and emergency treatment methods. In the event of an accident such as leakage, they can respond quickly and correctly.
In addition, whether it is storage or transportation, relevant regulations and standards must be strictly followed. Keep detailed records, including storage location, quantity changes, transportation routes, transportation time, and other information for traceability and management. Do not be negligent, so as not to cause safety accidents and endanger the lives of personnel and the environment.

I look at what you are asking, but I am inquiring about the market price of methyl 2-chloropyridine-6-carboxylate. However, the price of a product that changes in the market is variable and often varies due to factors such as time, place, quality and quantity.
In the past, the price of these chemical products may change due to the abundance of raw materials. If the raw materials required for its preparation are widely available and easily available, the price may be flat. If the time is right and the place is right, the rain in the raw material production area is good, and the supply is sufficient, the price of this methyl 2-chloropyridine-6-carboxylate may decrease steadily.
However, if the raw materials are scarce, or the production area is damaged due to natural and man-made disasters, and the supply is short, the price will rise. Or the production method is improved, the process is refined, and the cost is reduced, the price may also change.
And the state of market supply and demand is also the main reason. If many manufacturers compete for this product, the demand is greater than the supply, and the price is high; on the contrary, if the market is saturated, the supply exceeds the demand, and the price is low.
As for the exact price, it is difficult to tell. Because the quantity required by the inquirer is not known, the place to buy is not known, and the quality requirements are not detailed. Those who need to inquire carefully about the local chemical market, or consult a merchant specializing in this industry, can obtain a more accurate price. Generally speaking, in order to obtain an accurate price, when considering all factors, it must not be generalized.