2-Chloropyridine-3-carboxamide

2-Chloropyridine-3-formamide is one of the organic compounds. It has a wide range of uses and is often a key intermediate in the creation of drugs in the field of medicinal chemistry. The design and construction of drug molecules depend on various organic intermediates, while 2-chloropyridine-3-formamide has a special chemical structure and can introduce other functional groups through various chemical reactions, thereby deriving many compounds with specific pharmacological activities.
In the research and development of pesticides, 2-chloropyridine-3-formamide is also indispensable. Many high-efficiency and low-toxicity pesticide varieties are created. It is necessary to use this as the starting material to obtain pesticide active ingredients with insecticidal, bactericidal or herbicidal effects through chemical synthesis. Due to its structural characteristics, it can endow pesticides with better biological activity and environmental compatibility.
Furthermore, in the field of materials science, it also has applications. Or it can participate in the preparation of polymer materials with specific properties, and improve the physical and chemical properties of the materials by copolymerizing with other monomers, such as mechanical properties, thermal stability, etc.
Overall, 2-chloropyridine-3-formamide has important uses in many fields such as medicine, pesticides and materials due to its unique chemical structure, and is an important basic substance for the development of organic synthesis and related industries.

The synthesis method of 2-chloropyridine-3-formamide is quite complicated. A common method is to use 2-chloropyridine-3-formyl acid as the starting material. First, it is heated with thionyl chloride. In this step, the active chlorine atom of thionyl chloride reacts with the hydroxyl group in the acid to form 2-chloropyridine-3-formyl chloride. This reaction needs to be carried out at a suitable temperature and under the protection of inert gas to avoid impurities from mixing.
After 2-chloropyridine-3-formyl chloride is formed, it is slowly dropped into the low temperature reaction system containing excess concentrated ammonia water. The acyl chloride in the formyl chloride encounters ammonia water, the nitrogen atom in the ammonia molecule nucleophilically attacks the carbonyl carbon of the acyl chloride group, and the chloride ion leaves, so 2-chloropyridine-3-formamide is obtained. In this process, low temperature conditions can inhibit the occurrence of side reactions and improve the purity of the product.
Another way is to use 2-chloro-3-cyanopyridine as a raw material. It is first placed in an alkaline aqueous solution, an appropriate amount of catalyst is added, and hydrolysis is heated. The cyanyl group is gradually converted into carboxylammonium salt under alkaline conditions, and then acidified to obtain 2-chloropyridine-3-formic acid. The following steps are the same as the above method using 2-chloropyridine-3-formic acid as the starting material, that is, the target product is obtained by acylation and aminolysis.
There are also those who use pyridine as the starting material. The chlorination reaction of pyridine is first carried out, and the chlorine atom is introduced at the 2-position. This reaction requires specific catalysts and reaction conditions to control the positional selectivity of chlorine atoms. Then the formamide group is introduced at the 3-position, which can be achieved by multi-step reaction, or the formamide-containing precursor is first introduced, and then the target structure is converted. Each method has its own advantages and disadvantages, and needs to be selected according to actual needs, raw material availability and cost considerations.

2-Chloropyridine-3-formamide is one of the organic compounds. Its physical properties are quite important and are related to many practical applications.
Looking at its appearance, under room temperature and pressure, it is mostly in the state of white to light yellow crystalline powder, which is easy to observe and operate. The powder has good fluidity and is easy to disperse and mix in some preparation processes.
When it comes to the melting point, it is about 145-148 ° C. The melting point is the inherent characteristic of the substance. This value indicates that 2-chloropyridine-3-formamide will undergo a transition from solid to liquid state in this temperature range. The determination of the melting point can be used not only to identify the purity of the substance, but also to characterize its thermal stability.
As for solubility, 2-chloropyridine-3-formamide is slightly soluble in water. Water is a common solvent, and its slightly soluble properties reveal that the compound has a weak interaction with water molecules. However, it has good solubility in organic solvents such as dichloromethane, N, N-dimethylformamide (DMF). This property is of great significance in organic synthesis. When the reaction system is constructed, a suitable organic solvent can be selected according to its solubility to promote the reaction and facilitate the separation and purification of the product.
In addition, the physical properties such as the density of the substance also have specific values. Although not detailed, they are indispensable parameters in the fields of chemical production and material preparation, which have a profound impact on product quality and process design.

2-Chloropyridine-3-formamide, this is an organic compound with multiple chemical properties.
Its appearance is often white to pale yellow solid, soluble in specific organic solvents. In terms of chemical activity, amide groups are crucial. In the amide group, the nitrogen atom has a lone pair of electrons, which can be used as a hydrogen bond donor and receptor. This property also makes 2-chloropyridine-3-formamide play an important role in forming crystal structures or binding to biological macromolecules.
Furthermore, the pyridine ring also gives the compound unique properties. The pyridine ring is aromatic, stable and has a special electron cloud distribution. The chlorine atom at the second position can participate in the nucleophilic substitution reaction. Because of its certain electronegativity, the electron cloud density of the carbon atom at the ortho position is reduced, and it is easy to be attacked by nucleophilic reagents. If the nucleophilic reagent is a compound containing active hydrogen atoms, such as alcohols, amines, etc., the chlorine atom can be replaced to form a series of derivatives.
In addition, the nitrogen atom of the pyridine ring can be protonated to form a pyridine salt under acidic conditions, which enhances the water solubility of the compound, and the pyridine salt has unique reactivity and can be used for specific organic synthesis reactions.
At the same time Under acidic or basic conditions, amide bonds can be broken. Under acidic conditions, 2-chloropyridine-3-carboxylic acid and ammonium salts are hydrolyzed; under basic conditions, 2-chloropyridine-3-formate and ammonia are formed. These hydrolyzate products have potential application value in the fields of organic synthesis and medicinal chemistry.
2-chloropyridine-3-formamide contains pyridine ring, chlorine atom and formamide group. It has rich chemical properties and is widely used in organic synthesis, drug development and materials science.

The price range of 2-chloropyridine-3-formamide in the market is difficult to determine. The price of this chemical often varies for various reasons.
First, the cost of production is also. The price of raw materials may fluctuate with the supply and demand of the market. If its production requires rare and expensive raw materials, the price must be high; and the raw materials are easy to obtain and sufficient, and the price may be flat. And the production process is also related to the complexity. If the process is complicated, it requires many steps and equipment, which consumes money and effort, and the price will also increase.
Second, the supply and demand of the market has a huge impact. If at a certain time, in a certain area, many businesses need this product, and the demand exceeds the supply, the price will rise; on the contrary, if the production is large and the use is small, the supply will exceed the demand, and the price may drop.
Third, the source and the quality are also related to the price. A well-known factory has exquisite craftsmanship, high purity and quality of the product, and its price may be higher than ordinary. And the distance of transportation, the amount of taxes and fees, etc., can make the price different.
Therefore, in today's city, the price of 2-chloropyridine-3-formamide, low or hundreds of yuan per kilogram, high or thousands of yuan, it is difficult to determine a definite number, and it must be known according to the time and city.