2-(chloromethyl)H-imidazo[1,2-a]pyridine

2-%28chloromethyl%29H-imidazo%5B1%2C2-a%5Dpyridine, that is, 2- (chloromethyl) -H-imidazolo [1,2-a] pyridine, is widely used. In the field of medicinal chemistry, it is an important intermediate in organic synthesis. It can be cleverly reacted to construct many compounds with biological activity, which is very helpful for the development of new drugs. For example, when developing therapeutic drugs for specific diseases, it can be modified and derived as a basis, or innovative drugs with better efficacy and less side effects can be obtained.
It is also useful in the field of materials science. It can participate in the preparation process of certain functional materials, giving materials such as special optical, electrical or mechanical properties. By polymerizing with other monomers or chemically modifying them, it is expected to prepare polymer materials with unique properties, which can be used in optical devices, electronic components and other fields.
In addition, in the study of organic synthetic chemistry, 2- (chloromethyl) -H-imidazolo [1,2-a] pyridine is often used as a key raw material for the synthesis of complex organic molecules with special functions. Chemists have developed new synthesis methods and paths through in-depth exploration and clever use of their chemical properties, promoting the continuous development of organic synthetic chemistry.

2-%28chloromethyl%29H-imidazo%5B1%2C2-a%5Dpyridine is 2- (chloromethyl) -H-imidazolo [1,2-a] pyridine, and its synthesis method is as follows:
The starting material is to select related compounds containing pyridine structure and can be converted to chloromethyl. A common route is to start with a suitable substituted pyridine derivative, and first modify the pyridine ring to construct the basic skeleton of imidazolo [1,2-a] pyridine. For example, the imidazolo [1,2-a] pyridine structure is formed by a series of reactions such as condensation and cyclization using pyridine and reagents containing specific functional groups under the action of appropriate catalysts.
After forming the imidazolo [1,2-a] pyridine parent nucleus, chloromethyl is introduced. This step can be selected with different chloromethylation reagents, such as chloromethyl alkyl ethers. In the presence of catalysts such as Lewis acid, the reagent reacts with imidazolo [1,2-a] pyridine, and the chloromethyl is introduced to the target position, that is, the 2-position.
Or chloromethylation of pyridine derivatives is carried out first, and then cyclization is carried out to construct the structure of imidazolo [1,2-a] pyridine. It is necessary to pay attention to the precise regulation of reaction conditions in each step. Temperature, reaction time, and ratio of reactants will all affect the yield and selectivity of the reaction. In the reaction process, it is often necessary to use a variety of separation and purification methods, such as column chromatography, recrystallization, etc., to obtain high-purity 2- (chloromethyl) -H-imidazolo [1,2-a] pyridine products. In short, the synthesis of this compound requires flexible selection of synthesis routes and optimization of reaction conditions according to actual conditions.

2-% (chloromethyl) H-imidazo [1,2-a] pyridine is an organic compound with unique physical properties.
Its shape or crystalline solid is usually white to pale yellow powder with fine texture. This shape is due to the interaction between molecules, which causes it to exist in this form at room temperature and pressure.
The melting point is crucial for the identification and purification of this compound. The melting point is experimentally determined to be in a specific temperature range. This property allows the purity of the substance to be identified by melting point measurement. If the purity is high, the melting point range is narrow and close to the theoretical value; if it contains impurities, the melting point is reduced and the range is wider.
The boiling point is related to the volatility and thermal stability of the compound. Under a specific pressure, when 2% (chloromethyl) H-imidazo [1,2-a] pyridine reaches the boiling point, it changes from liquid to gaseous state. The boiling point reflects the strength of the intermolecular force, the force is strong, the boiling point is high, and more energy is required to overcome the attractive force between molecules to cause gasification.
Solubility reflects the solubility of the compound in different solvents. In organic solvents such as ethanol and dichloromethane, 2% (chloromethyl) H-imidazo [1,2-a] pyridine may have good solubility. Due to the similarity of the molecular structure with organic solvents, it can form hydrogen bonds or van der Waals forces with solvent molecules to promote dissolution; while in water, its solubility may be poor due to its molecular polarity.
The density is the mass of the substance per unit volume, and the density of 2-% (chloromethyl) H-imidazo [1,2-a] pyridine is comparable to that of other similar organic compounds. It has a definite value under a specific temperature and pressure. This value is of great significance to chemical experiments and industrial production involving mass and volume conversion.
In addition, the compound may have a certain smell. Although the smell description of your mileage may vary, chemists often use specific words to describe it, such as weak irritating odor. This odor originates from the molecular structure and volatility. Volatile substances come into contact with olfactory receptors and make people perceive odors.

2-%28chloromethyl%29H-imidazo%5B1%2C2-a%5Dpyridine, it is one of the organic compounds. It has unique chemical properties and is related to many fields such as organic synthesis and medicinal chemistry.
In this compound, the presence of chloromethyl gives it special reactivity. In chloromethyl, the chlorine atom has strong electronegativity, which can make the carbon atoms connected to it partially positive, so it is prone to nucleophilic substitution reactions. Many nucleophilic reagents, such as alcohols and amines, can react with it to generate corresponding substitution products. This property is very useful when constructing complex organic molecular structures.
Furthermore, the parent nuclear structure of H-imidazo [1,2-a] pyridine also has a great influence on its chemical properties. This parent nucleus contains nitrogen heterocycles, which are basic to a certain extent, because the lone pair electrons on the nitrogen atom can accept protons. And the conjugated system of the parent nucleus makes it have certain stability and electron delocalization characteristics.
And due to the spatial structure of the molecule, 2 - (chloromethyl) H - imidazo [1,2 - a] pyridine may exhibit stereochemical selectivity in the reaction. In the design of the organic synthesis path, the activity and selectivity of each reaction check point need to be carefully considered, so that the reaction can proceed in the expected direction.
At the same time, in the field of medicinal chemistry, such compounds containing nitrogen heterocycles and chloromethyl groups may interact with specific targets in organisms, exhibiting potential biological activities, such as antibacterial, antiviral, anti-tumor, etc., and have become important research objects for drug development.

In today's world, business conditions are unpredictable, and it is difficult to determine the price range of 2- (chloromethyl) H-imidazolo [1,2-a] pyridine in the market. The price of this compound often changes for many reasons.
The first to bear the brunt is the cost of production. The price of raw materials, the difficulty of preparation, and the simplicity of the process are all related to cost. If the raw material is rare and difficult to find, or the preparation process requires exquisite methods and expensive equipment, the cost will be high, and the price will also rise.
Furthermore, the market supply and demand trend also affects its price. If there are many buyers for this product, but there are few suppliers, the supply is in short supply, and the price will rise; on the contrary, if the supply exceeds the demand, the merchant will sell its goods or reduce the price.
In addition, the quality is also the key. High-quality products, because they can meet specific needs, are often higher than ordinary ones.
In addition, differences in regions, trade policies, and transportation costs can all affect their prices.
According to the current situation, according to rumors in the city and past business conditions, the price of 2- (chloromethyl) H-imidazolo [1,2-a] pyridine ranges from a few yuan to tens of yuan per gram. However, this is only a rough estimate, and the actual price still needs to be asked by the franchisees and industry experts, and it is difficult to determine the number due to changes in time.