2-(chloromethyl)-4-(3-methoxypropoxy)-3-methylpyridine

2-%28chloromethyl%29-4-%283-methoxypropoxy%29-3-methylpyridine that is, 2- (chloromethyl) -4- (3-methoxypropoxy) -3-methylpyridine, this compound has a wide range of uses.
In the field of medicine, it may be a key intermediate for the synthesis of specific drugs. In pharmaceutical chemistry, pyridine compounds are common, and their structures can endow drugs with unique activities and properties. The chloromethyl, methoxypropoxy and methyl substituents of this compound may affect the ability of drugs to bind to targets, thereby altering the efficacy, selectivity and metabolic properties of drugs. For example, chloromethyl has high activity, or participates in nucleophilic substitution reactions, which helps to build complex drug structures; 3-methoxy propoxy or enhances drug fat solubility, which is conducive to drug penetration through biofilms and improves bioavailability.
In the field of materials science, this compound may be used as a raw material for functional material synthesis. Because it contains nitrogen heterocycles and various functional groups, it may endow materials with special electrical, optical or chemical properties. For example, when preparing organic semiconductor materials, the pyridine ring can adjust the molecular orbital energy level of the material, which affects the carrier transport performance; methoxy propoxy may improve the solubility and processability of the material, which is convenient for material film formation or molding.
In organic synthetic chemistry, it is an important synthetic block. The complex organic molecular structures can be constructed by various organic reactions, such as nucleophilic substitution, oxidation, reduction, etc. Chemists can synthesize compounds with specific structures and functions, and expand the chemical boundaries of organic synthesis.

To prepare 2- (chloromethyl) -4- (3-methoxypropoxy) -3-methylpyridine, there are many methods, and the following is one way.
Take 3-methyl-4-hydroxypyridine as the starting material and react it with 3-methoxypropyl halide in an alkaline environment. The base can be selected from potassium carbonate or the like, and the solvent is preferably acetonitrile. This reaction aims to make the hydroxyl group nucleophilic substitution with 3-methoxypropyl halide to obtain 4- (3-methoxypropoxy) -3-methylpyridine. < Br >
Then, the resulting product is chloromethylated. Usually, paraformaldehyde and hydrogen chloride gas are used as reagents, and they are reacted in a suitable solvent such as dichloromethane at a suitable temperature. Under the action of hydrogen chloride, paraformaldehyde generates an active chloromethylation reagent, which attacks the 2-position of the pyridine ring, and finally obtains 2- (chloromethyl) -4- (3-methoxypropoxy) -3-methylpyridine.
After the reaction is completed, the product needs to be separated and purified. The column chromatography can be used to select silica gel as the fixed phase and rinse with an appropriate proportion of eluent to obtain a purified product. Or use the method of recrystallization to select a suitable solvent to precipitate the product and achieve the purpose of purification.
There are other methods, which can start from pyridine derivatives and go through multi-step reactions, such as substitution, oxidation, reduction, etc., according to different reaction sequences and conditions, the purpose of synthesis can also be achieved. However, it is necessary to carefully choose the appropriate method according to the actual materials, equipment and cost factors.

2-%28chloromethyl%29-4-%283-methoxypropoxy%29-3-methylpyridine is an organic compound. Looking at its structure, it is based on a pyridine ring, which is connected with groups such as chloromethyl, 3-methoxypropoxy, and methyl. The physical properties of this compound are related to the characteristics of the groups contained.
First of all, the appearance of organic compounds containing chloromethyl groups is often colorless to light yellow liquid or solid. If the intermolecular force is strong, or due to the orderly arrangement of crystals, it is a solid; if the intermolecular force is weak and the molecular movement is relatively free, it will be liquid.
Besides the melting point and boiling point, the existence of chloromethyl groups, because of its high electronegativity, can enhance the intermolecular force, causing the melting point and boiling point to rise. And 3-methoxypropoxy, the chain structure increases the molecular volume and flexibility, or disperses the intermolecular forces, which has a complex effect on the melting point and boiling point. Methyl is the power supply group, and has relatively little effect on the intermolecular forces. In general, its melting point and boiling point need to be accurately determined by experiments, but the range can be roughly deduced from the group.
In terms of solubility, chloromethyl has a certain polarity, 3-methoxypropoxy contains methoxy and ether bonds, and also increases polarity. The pyridine ring is weakly basic and has a certain polarity. Therefore, the compound may have good solubility in polar organic solvents such as ethanol and acetone; in non-polar solvents such as n-hexane, its solubility may be poor.
In terms of density, due to the presence of chlorine atoms, the atomic weight is large, which may make the compound denser than ordinary hydrocarbons. However, the exact density still needs to be measured experimentally.
In addition, the compound may have a certain volatility, and the volatility strength is related to the intermolecular force and boiling point. Those with weak intermolecular force and low boiling point have strong volatility.
The physical properties of the compound discussed above are all speculated according to the characteristics of the groups in the structure. The exact value still needs to be determined experimentally to be accurate.

2-%28chloromethyl%29-4-%283-methoxypropoxy%29-3-methylpyridine, this is an organic compound with unique chemical properties. Its molecules contain groups such as chloromethyl, methoxypropoxy and methyl, which have a significant impact on its properties.
First of all, solubility, this compound contains polar methoxy groups, or has a certain solubility in polar organic solvents such as methanol, ethanol, and acetone. Polar groups interact with solvent molecules to promote their dissolution. However, chloromethyl groups and pyridine rings have certain hydrophobicity, so their solubility in water may be limited.
In terms of chemical stability, pyridine rings are relatively stable and aromatic. However, chlorine atoms in chloromethyl groups are active and prone to nucleophilic substitution reactions. In case of nucleophilic reagents, such as alcohols, amines, chlorine atoms or are replaced, new derivatives are formed. This reactive activity provides the possibility to construct new compounds in organic synthesis.
Besides its reaction characteristics, the oxygen atom in the methoxy propoxy group has a lone pair of electrons, which can be used as a nucleophilic check point to participate in the reaction. At the same time, the nitrogen atom on the pyridine ring can also participate in the coordination reaction and form complexes with metal ions, which may have applications in the fields of catalysis and materials science.
Because its structure contains a variety of functional groups, it is widely used in the field of organic synthesis. It can be converted into compounds with different biological activities or material properties through a series of reactions. Or as a lead compound in medicinal chemistry, through structural modification and optimization, specific pharmacological active drug molecules are obtained.

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