2-CHLOROMETHYL-3-METHYL-4-(3-METHOXYPROPOXY)-PYRIDINE

2-Chloromethyl-3-methyl-4- (3-methoxypropoxy) pyridine is an organic compound. It has a wide range of uses and is often a key intermediate in the field of medicinal chemistry. Through specific chemical reactions, it can be converted into drug molecules with specific biological activities for the development of new drugs for the treatment of various diseases.
In the field of pesticide chemistry, it also has important applications. It can be used as a raw material for the synthesis of new pesticides, giving pesticides unique chemical structures and properties, enhancing pest control effects, and relatively small impact on the environment, in line with the current green agricultural development needs.
In the field of materials science, this compound can participate in the synthesis of certain functional materials. For example, polymerization with other monomers is carried out to prepare polymer materials with special electrical, optical or mechanical properties, which are used in electronic devices, optical instruments and other fields.
In addition, in organic synthetic chemistry, as a unique structural unit, it provides the possibility to construct complex organic molecules. Chemists can use its specific functional groups to carry out diverse reactions, expand the structural diversity of organic compounds, and inject new vitality into the development of organic synthetic chemistry. Its application in many fields has shown its important value in modern chemical industry.

The synthesis method of 2-chloromethyl-3-methyl-4- (3-methoxypropoxy) pyridine is not detailed in "Tiangong Kaiwu", but it can be deduced from the ancient chemical technology ideas.
First, the selection of raw materials is crucial. To prepare this product, the corresponding compound containing pyridine structure, chloromethyl, methyl, and methoxypropoxy should be selected as the starting material. If 3-methyl-4-hydroxypyridine is used as the base, and its pyridine ring and methyl are already present, under appropriate conditions, it can be reacted with a reagent containing chloromethyl to introduce chloromethyl. In this case, chloromethylation reagents, such as chloromethyl ethers, can be used in an acid-catalyzed environment to undergo electrophilic substitution reactions, so that chloromethyl is attached to the appropriate position of the pyridine ring.
Second, the introduction of 3-methoxy-propoxy is also critical. Using 3-methoxy-1-halopropane as a reagent, in the presence of a base, reacts with pyridine intermediates containing chloromethyl and methyl. The alkali can take away the hydrogen of the pyridine hydroxyl group and generate a nucleophilic oxygen anion. The carbon attached to the halogen atom of 3-methoxy-1-halopropane can be replaced by nucleophilic substitution to form a structure in which the 3-methoxy propoxy group is connected to the pyridine ring.
Third, the control of the reaction conditions should not be underestimated. Temperature, reaction time, and the proportion of reactants all affect the yield and purity. During chloromethylation, if the temperature is too high or there are too many side reactions, if it is too low, the reaction rate will be slow. For nucleophilic substitution involving alkali, the strength and dosage of the base must be accurate. If the alkali strength is too strong or the pyridine ring is destroyed, the And the reaction time is too short, the conversion is not sufficient; if it is too long, the product may decompose.
Fourth, the separation and purification of the product is also necessary. After the reaction is completed, the system may contain unreacted raw materials, by-products, etc. Extraction, distillation, column chromatography and other methods can be used. Extract with a suitable organic solvent, transfer the product from the reaction mixture to the organic phase, and separate the impurities with the aqueous phase; distillation separates the product and different impurities at the boiling point according to the difference of the boiling point of each component; column chromatography is based on the difference in adsorption and distribution of each component in the stationary phase and the mobile phase to obtain pure 2-chloromethyl-3-methyl-4 - (3-methoxypropoxy) pyridine.

2-Chloromethyl-3-methyl-4- (3-methoxypropoxy) pyridine has a very important physical and chemical properties, which are related to many chemical and scientific research uses.
Looking at its physical properties, it is often liquid at room temperature, but it also varies slightly depending on the surrounding temperature and humidity conditions. Its color is nearly colorless and transparent, with a slight yellowish sometimes, like the faint light of the early morning light. Smell it, it has a specific smell, not pungent and intolerable, but also clear and discernible, just as the ancient books say "things have their own gas, and gas can be discerned".
As for solubility, in common organic solvents such as ethanol and ether, it can be well miscible with each other, just like water and emulsion blend, and there is no distinction between each other. This characteristic is just like what the ancients said "seek the same gas, and the same kind dissolves". Because the organic solvent is compatible with the molecular structure, polarity and other factors of the pyridine derivative, it can blend seamlessly.
In terms of its chemical properties, the chloromethyl part of this pyridine derivative is active and abnormal, and it is easy to participate in the nucleophilic substitution reaction. Just like a martial arts master, he is agile and easy to fight with other things. When encountering nucleophilic reagents, the chlorine atoms are like arrows that leave the string, leaving quickly, paving the way for the formation of new bonds. The methoxy propoxy part of it, although slightly mild, can also exhibit chemical activity under certain conditions, or participate in reactions such as the breaking and rearrangement of ether bonds, as if it is strategizing behind the scenes and dominating the direction of chemical reactions. In addition, the nitrogen atom of the pyridine ring can be used as a Lewis base due to its lone pair of electrons, interacting with acids or molecules with electron-deficient centers, just like a soft method to play a unique role in chemical reactions.
In summary, 2-chloromethyl-3-methyl-4- (3-methoxypropoxy) pyridine has rich and unique physical and chemical properties, and has extraordinary potential in many fields such as chemical synthesis and drug development. It is a treasure of scientific research and industrial production.

There are 2-chloromethyl-3-methyl-4- (3-methoxypropoxy) pyridine today, and the price in the market is geometric, and it is difficult to determine. Prices in the market often change due to many reasons, and cannot be generalized.
According to Guanfu's "Tiangong Kaiwu", the price of various materials in the past also varies with time, place of origin, and supply and demand. The price of this 2-chloromethyl-3-methyl-4- (3-methoxypropoxy) pyridine fluctuates due to the difficulty of preparation, the price of materials used, and the amount of demand.
If it is difficult to make, and the materials used are rare, the price will be very high; if there are many people who need it, but there are few people who produce it, and the supply is in short supply, the price should also be high. On the contrary, if it is easy to make, sufficient materials are used, and the demand is rare, the price may become more affordable.
However, I have not personally been involved in the market where this product is traded, and there is no detailed price information at present, so it is difficult to determine its price. If you want to know its exact price, it is advisable to go to the place where the chemical materials are traded and consult the merchants, or you can get the exact price in the near future.

2-Chloromethyl-3-methyl-4- (3-methoxypropoxy) pyridine is an organic compound that has important uses in fine chemical fields such as medicine and pesticides. However, the relevant records of its manufacturers are difficult to find a direct correspondence in ancient books and documents. Today, based on ancient literature, I speculate about the situation of today's manufacturers of this compound.
At present, science and technology are prosperous, and the chemical industry is booming. Many chemical giants and specialized factories are involved in the production of this compound. Among them, some large factories produce this product on a large scale with strong financial resources, advanced equipment and exquisite skills. There are many workshops in the factory, and the craftsmen are all skilled in chemical technology, controlling all aspects of production to ensure the quality of the products.
There are also small factories with expertise, although the scale is slightly inferior, but they are ingenious and focus on the research and development and production of this compound. With flexible strategies and innovative thinking, they have won a place in the market. The craftsmen in the factory study day and night, striving for excellent product quality and advanced craftsmanship.
There are also foreign-funded factories, bringing overseas advanced methods, settled in Huaxia. It combines foreign experience with local advantages to produce 2-chloromethyl-3-methyl-4- (3-methoxypropoxy) pyridine, which is also unique and important for the market.
Manufacturers are scattered all over the world, or in the prosperous economic areas along the coast, with the convenience of transportation, raw materials and products can be transported smoothly; or in inland resource-rich places, the cost of production can be reduced according to the benefit of raw materials. Although there is no detailed description of such manufacturers in ancient books, today's chemical industry is flourishing, and various factories have made their own efforts to add luster to the production of 2-chloromethyl-3-methyl-4- (3-methoxypropoxy) pyridine to meet the needs of the market and promote the prosperity of the chemical industry.